Purulent Pleurisy Revealing Lymphoblastic Lymphoma Type T: A Pediatric Case Report (original) (raw)
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Extensive pleural involvement in pediatric T-Cell lymphoblastic lymphoma
Indian Journal of Nuclear Medicine
Lymphoblastic lymphoma (LBL) is the common non-Hodgkin lymphoma in childhood and adolescence. T-cell LBL (T-LBL) usually manifests with an anterior mediastinal mass and disseminated disease. We present a 12-year-old girl with progressive neck swelling and dyspnea for 1 year. Fluorodeoxyglucose positron-emission tomography/computed tomography done for pretreatment staging unveiled hypermetabolic lymph nodes on both sides of the diaphragm with splenic and bone marrow involvement. Apart from these, there was the extensive involvement of the left pleura. Biopsy and immunohistochemistry revealed T-LBL. The extensive secondary pleural involvement in pediatric T-LBL is rarely seen and needs to be reported.
Primary pleural non-Hodgkin lymphoma in a child—an exceedingly rare disease
Journal of Pediatric Surgery, 2012
Primary pleural lymphomas are very rare. Two types are described in the literature: primary effusion lymphoma, in the setting of human immunodeficiency virus infection, and pyothoraxassociated lymphomas, with a strong Epstein-Barr virus association. We report a rare case of a primary pleural lymphoma in a 12-year-old immunocompetent girl who presented with a hemorrhagic pleural effusion and had plaque-like thickening of the pleura. The histologic and immunophenotypic findings conformed to that of a diffuse large B-cell lymphoma (CD20 positive).
Primary Pleural Lymphoma: Case Report
British Journal of Healthcare and Medical Research, 2023
We report a case of a 70-year-old female with a history of prolonged exposure to biomass during childhood, non-smoker and no history of exposure to people with tuberculosis who presented with progressive dyspnea. Chest CT showed circumferential and nodular suitable pleural thickening with involvement of the mediastinal pleura and ipsilateral pleural effusion. An ultrasound-guided pleural biopsy was performed with a Trucut needle. The Histopathology result of the pleural biopsy determined an infiltration due to non-Hodkin lymphoma of lineage B. Immunohistochemistry CD20 positive, CD3 Positive. This case is thought to be a very rare case of primary malignant lymphoma arising in the pleura without a history of chronic pleural inflammation or immunocompromise.
Revista de Chimie
The goal of pleural fluid assessment is to establish with certainty its etiology and major challenge is the etiologic diagnosis precocity. Pleural effusion as the first and the only event in the onset of non-Hodgkin lymphoma is atypically in the absence of other signs and symptoms. Follicular lymphoma (FL) also called indolent lymphoma the most frequent is a low-grade non-Hodgkin’s lymphoma (NHL). In patients with indolent lymphoma affecting the pleura and pericardium is atypical and appears only in aggressive forms, so the onset with pleural effusion is unusual. Serous effusions may occur from onset or during evolution of various subtypes of T cell originated lymphomas or high-grade B cell lymphomas. Primary pleural lymphomas (PPL) have been described at patients with human immunodeficiency virus infection; tuberculosis complicated with chronic pyothorax or after exposure to asbestos. Compared to other similar cases previously reported in the medical literature, the novelty of this...
Presentation of lymphoma in childhood
IAR Consortium, 2023
Background: Lymphomas are the third most common group of malignant tumor in children; they are rapidly growing neoplasm, with a propensity fewer spread dissemination, and should be investigation and treated as expeditiously possible Aim of the study: To study epidemiological, clinical & pathological features of lymphoma in Iraqi children Method: Over a period of 7 years (from January 2003 to December 2009) all the cases diagnosed & treated as lymphoma in the oncology unit of the Child Central Teaching Hospital (Baghdad) were reviewed retrospectively. Result:-the total number of cases studied was 118 cases.40% of cases diagnosed during (2003,2004) while only 5% diagnose in 2007,NHL represent the most common type (80.5%) and HL account for (19.4%). regarding HL : the age range was between (2years-15 years), median age was 7 years , peak age was between (5-9 years) , male /female ratio was 5:1, cervical LAP represents the most common mode of presentation (95.6%). Mixed cellularity was the most histopathological subtype (60.8%), & most of patients with advanced disease stage (III, IV) (65.1%). Regarding NHL: the age range was between (9m-16 years), median age was 8 years, peak age was between (5-9 years) and male /female ratio was 2.1:1. Abdominal mass (distention) was the most common mode of presentation (61%). BL&BLL was the most common subtype (56.8%), &most of patient presented with advanced disease (stage III&IV) 86.2%. Conclusion:-the study show male predominant in both type of lymphoma,NHL was the most common subtype of lymphoma, MC the most common subtype of HL while BL&BLL was the most common subtype of NHL and high percentage of patients (HL&NHL) presented with advanced disease.
Isolated Malignant Pleural Effusion in a Child: Unusual Presentation of Acute Leukemia
Curēus, 2024
Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably, Streptococcus pneumoniae stands out as the predominant infectious agent responsible for this condition. Non-infectious causative factors encompass hematolymphoid malignancies, congestive heart failure, hemothorax, hypoalbuminemia, and iatrogenic causes. Among the hematolymphoid malignancies, lymphoma emerges as the most prevalent malignancy associated with pleural effusion. It is followed by T-cell lymphoblastic leukemia, germ cell tumor, neurogenic tumor, chest wall and pulmonary malignancy, carcinoid tumor, pleuro-pulmonary blastoma, and Askin's tumor, among others. Malignant pleural effusion is predominantly linked to T-cell lymphoblastic malignancies. In the context of acute lymphoblastic leukemia (ALL), cases where T-cell presentation is accompanied by leukemic pleural effusion are commonly associated with either a mediastinal mass or significant lymphadenopathy. Here, we describe a case of a four-year-old male child who exhibited a brief history of febrile illness. Notably, this case was characterized by isolated pleural effusion, devoid of any mediastinal mass or lymphadenopathy. Pathological investigations of pleural fluid analysis revealed the presence of malignant cells, facilitating an expedited diagnosis.
INFANT ANAPLASTIC LYMPHOMA: Case Report and Review of the Literature
Pediatric Hematology and Oncology, 2007
Anaplastic large cell lymphoma (ALCL) is a well-known entity, but there are no data on prognosis according to the age of the patient, especially in infants. A 2-month-old girl was admitted with a 2-week history of coughing, fever, and lymphadenopathy. Physical examination revealed mild respiratory distress, an erythematous macular rash on her trunk, massive cervical lymphadenopathy, splenomegaly, and very mild ascites. Chest radiograph showed bilateral pulmonary infiltrates, pleural effusion, and a mediastinal mass. CBC count showed WBC: 172,000/µL (PMN 40%, lymphocytes 47%, monocytes 3%); hemoglobin concentration: 8.7 g/dL; platelets: 390,000/µL. Cervical lymph node biopsy revealed anaplastic lymphoma with positive staining to ALK 1 and TIA 1. Immunophenotypic analysis of peripheral and bone marrow lymphoid cells showed an aberrant T-cell immunophenotype, including expression of CD3, CD45R0 + , CD43 + , and CD30 +. Cytogenetic analysis performed on blood and bone marrow samples demontrated the translocation t(2;5) (p23;q35), and trisomy 47. After leucophoresis, the child received chemotherapy according to the ALCL-99-EICNHL protocol, and was started on corticosteroids and cyclophosphamide, which resulted in marked improvement. After the second course, WBC decreased to 6000/µL without tumor lysis syndrome, but the child developed bacterial and fungal disseminated infections and died of septic shock with multiorgan failure. This report is of a rare case of infant anaplastic lymphoma and excellent response to treatment. Unfortunately, she did succomb to overwhelming infection. More reports of similar cases may determine the cause and prognosis of such children, helping to
T-Cell Acute Lymphoblastic Leukemia Presenting with Pleural Effusion: A Case Report
Respiratory Case Reports, 2021
Acute lymphoblastic leukemia is a heterogeneous group of lymphoid disorders that are linked to the monoclonal proliferation and expansion of immature lymphoid cells in the bone marrow, blood and organs. The clinical presentation of acute lymphoblastic leukemia is usually nonspecific, while symptoms typically include fatigue, lack of energy, easy bruising or obvious bleeding, dyspnea, dizziness and infections, and B symptoms such as fever, night sweats or weight loss can occur. Pleural effusion, as the first clinical manifestation of acute lymphoblastic leukemia, is relatively rare. We present here the case of a 55year-old female patient diagnosed with T-cell Acute Lymphoblastic Leukemia based on examinations performed due to pleural effusion.