Evaluation of Platelet Indices in Patients With Dengue Infections (original) (raw)

Diagnostic Significance of Platelet Indices in Dengue Fever in Endemic Area

https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.2\_Feb2020/Abstract\_IJRR0050.html, 2020

Aim and Objective: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. The aim to study role of various platelet indices (MPV, PDW, PCT) in early diagnosis of Dengue fever in patient belong from endemic area, patients admitted in MBS Hospital KOTA, a tertiary care hospital in Rajasthan with a diagnosis of Dengue fever according to WHO protocol from December 2018 to January 2020 Methods: Prospective observational study was undertaken among adult patients in a MBS hospital Kota. 132 patients were studied and analysed. These 132 patients were grouped into three according to the platelet count (<20000,20000- 100000, >100000). The patients admitted in our hospital with features suggestive of Dengue fever were taken for the study and diagnosis was confirmed with Dengue IgM ELISA test. CBC were determined using automated counter, five-part haematology analyser in central laboratory of MBS hospital Kota. Result; among 132 patients 22Patients had platelet counts below 20,000 the mean PDW was 17.29fl, 80 cases with platelet counts between 20,000 to 100000, the mean PDW was 16.5fl and 30 cases with platelet counts above 100000 the mean PDW was 13.8fl which showed statistically significant difference between the groups (p value 0.001). The mean MPV values were 9.2fl in 22 patients with platelet counts below 20,000 and 12fl in 80 cases with platelet counts 20,000 to 100000 and 13.7fL in 30 patients with platelet count above 100000. There was statistically significant difference between the groups (p value 0.001). The mean PCT value were 0.03% in 22 patients with platelet counts below 20,000 and 0.1% in 80 cases with platelet counts 20,000 to 100000 and 0.1% in 30 patients with platelet count above 100000. There was statistically significant difference between the groups (p value 0.001). Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, plateletcrit are useful to monitor dengue fever. Decrease MPV,PCT and increase PDW is significant in platelet count <100000/mm3 and Platelet indices plays significant role in early predictive diagnosis and severity of dengue in endemic area.

Analysis of Platelet Indices and its correlation with platelet count In Dengue

International Journal of Research in Pharmaceutical Sciences, 2020

Dengue is a global arboviral disease of growing public health concern. Several parameters have been used to detect the infection and severity of dengue. Recent evidence suggests that platelet indices can be used to assess the severity and prognosis of dengue infection. This retrospective study aims at assessing the role of the platelet indices – Mean Platelet Volume (MPV), Platelet Distribution Width, (PDW), P-LCR (Platelet Large Cell Ratio) and Plateletcrit (PCT) and its correlation with the platelet count in 50 Dengue NS1 antigen positive cases and to find the sex ratio and the age-wise distribution of the dengue cases. The indices were obtained using an Automated Hematology analyzer and were compared with the platelet count, considering p-value <0.05 as statistically significant. Thrombocytopenia was found in a majority of the cases and PDW and PLCR were found to be inversely proportional to the platelet count. MPV was found to have no correlation with the platelet count. Henc...

Role of platelet parameters and hematological profile in dengue positive cases

International Journal of Scientific Reports, 2021

Except for few hilly and dry regions where the environment is unfavourable for mosquito breeding, the outbreaks of the disease have been reported in almost entire India. 2 Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are life threatening reversible vascular complications of dengue fever (DF) and are associated with severe thrombocytopenia bleeding and increased vascular permeability. To predict the severity of the disease decreasing platelet counts are ABSTRACT Background: Dengue is an endemic in tropical and subtropical regions of the world and also in various parts of India. Recent evidence indicates that platelet indices can be used to assess the severity and prognosis of dengue. This study aimed to assess the role of the platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), platelet to large cell ratio (P-LCR), plateletcrit (Pct) and hematological parameters like hemoglobin (Hb), hematocrit (Hct) with the platelet count in dengue NS1 antigen positive cases. Methods: An observational cross-sectional study conducted on cases of dengue over a period of 3 months admitted with serological positivity (NS1 antigen) in a tertiary care hospital, Loni. The platelet indices like MPV, PDW, Pct, P-LCR and hematological parameters like Hb, Hct were noted using Sysmex XN-3100 Automated hematology analyzer and compared with platelet count. Results: Relationship between various platelet indices like MPV, PDW, P-LCR and PCT and hematological parameters like Hb, TLC and Hct were related with platelet count. Dengue positive cases were inversely related to MPV, PDW, P-LCR, Hb and Hct and directly related to Pct. In the present study Pct, P-LCR, Hb and Hct were statistically significant in correlation with platelet count. Conclusions: Pct, P-LCR, Hb and Hct along with platelet count can be used to assess the predictive outcomes in case of dengue infection.

Correlated Study of Dengue Serological markers and Platelet count

International Archives of BioMedical and Clinical Research, 2018

Background: Dengue being the most prevalent mosquito borne arboviral infection in India, has become endemic in India with every year outbreaks. Despite substantial efforts to control the mosquito populations, dengue fever has spread, emerged and established itself rapidly. Objectives: This study is to correlate the platelet count and IgM /IgG and NS1 in the acute stage of dengue infection Materials & Methods: The present study was conducted for a period of 22 months in Heritage Institute of Medical Sciences from January 2016 to November 2017. Blood samples were collected from 1347 suspected Dengue patients. In all the serologically positive cases, serological confirmation and evaluation of platelet counts of dengue infection was done. Results: A total of 1347 suspected cases were admitted during the study period and among them, 155 (11.51%) were found to be seropositive for dengue. Among the dengue cases, Males (61.05%) were affected more than females (38.7%). Out of 155 positive c...

Importance of Platelet Count in Diagnosis of Dengue Infection

Bioinfo publication, 2018

- Introduction: Dengue is an acute, potentially fatal viral infection that can culminate into dengue hemorrhagic fever and dengue shock syndrome. It has emerged as a notable public health problem in recent decades in terms of the mortality and morbidity associated with it. Specific antibody Ig M and Ig G detection along with the newer parameter NS1 antigen detection has been the main stay of diagnosis. Apart from these parameters, thrombocytopenia is a constant finding and therefore platelet count can be used as an accessory test for diagnosis of dengue infection in the laboratories where resourc es are limited. Materials and Methods: A cross-sectional study was conducted using secondary data of clinically suspected dengue cases reported to the microbiology laboratory during June-August months of 2017 at CIMS teaching hospital, Chamarajanagar. Samples were tested either for NS1or IgM by ELISA depending on duration of fever and platelet counts were obtained. Statistical analysis was done using WHO Epi info software version 3.5.4. Results: Out of 1653 clinically suspected cases, 265(16.03%) were found to be positive for dengue infection either by NS1 or IgM ELISA. Among them 135 (50.95%) were females and majority 211 (79.62) were below the age of 30 years. Proportion of thrombocytopenia was significantly higher in dengue positive cases than in negatives. Conclusion: In resource limited setting thrombocytopenia can be used as predictor of dengue infection for early initiation of therapy to reduce the morbidity and mortality associated with it.

Correlation of enhancement Mean Platelet Volume (MPV) with severity of dengue infection

IOP Conference Series: Materials Science and Engineering, 2018

Dengue infection is one of the infectious diseases which become a health problem in the world. Platelets play an important role in the pathogenesis of dengue. The quantity of platelet related to dengue were often discussed but the quality of platelet related to dengue infection were rarely discussed. The activation of platelets can be observe indirectly through changes in MPV. Aim of this study is to analyze the prevalence ratio of MPV enhancement in dengue hemorrhagic fever (DHF) compared to dengue fever (DF). This study is an observational analytical study with a cross-sectional design to analyze the prevalence ratio of enhancement MPV in DHF compared to DF. The subjects were dengue suspected patients that hospitalized in Dr. Sardjito General Hospital and PKU Muhammadiyah Hospital Yogyakarta who meet the inclusion and exclusion criteria. Venous blood were collected into 2 mL EDTA tube for automatical hematology analysis. Chi-square was used to analyze different proportions of MPV enhancement between DHF and DF groups. One hundred subjects were participated in this study and classified into DF and DHF based on WHO 2011 criteria. Prevalence ratio of MPV enhancement ≥9.7 fL was 4.8 (95% CI 2.8-37.0), p<0.0001. The result indicates that MPV enhancement was a risk factor of worsening dengue infection.

Evaluation of platelet indices in dengue fever in a tertiary care hospital in Bangladesh

International Journal of Advances in Medicine

Background: Dengue fever is the most rapidly spreading mosquito-borne viral diseases in the world. Some evidence suggests that platelet indices may have diagnostic and prognostic value in Dengue fever. The aim of the study is to evaluate platelet indices and to find their correlation between platelet count in Dengue fever. Methods: This retrospective cross-sectional study was conducted through the use of stored data in Bangabandhu Sheikh Mujib Medical University (BSMMU) dengue cell from July 2019 to September 2019 at department of laboratory medicine and department of internal medicine, BSMMU, Dhaka. Among them, clinical records of 260 cases are preserved in a structured clinical record form (CRF). After ethical clearance from institutional review board (IRB), form clinical records of 260 cases which were preserved in a structured CRF patients who fulfilled the inclusion and exclusion criteria was selected as study population. Results: Platelet indices (MPV and PDW) were statistical...

Role of Platelet Indices in Patients with Dengue Infection in Red Sea State, Sudan

Dengue is a global endemic and most prevalent human arbovirus disease. Recently, platelet indices have been assessed usefully in the diagnosis conditions with abnormal platelet counts. A case control study was conducted to investigate and assess the role of platelet indices in patients with dengue infection in Red Sea State, Sudan. Platelet counts (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR) were measured. MPV and PLT were significantly lower in cases of dengue (P<0.000). The PDW and P-LCR were significantly high in cases of dengue (P<0.000 and 0.431 respectively). Low PLT, MPV and PDW may be used as probable indicators for dengue in endemic area. MPV <9 fl and PDW >13fl shows considerable sensitivity for dengue fever.

Utility of Red Cell and Platelet Indices Evaluation of Severity of Dengue Infection

Annals of Pathology and Laboratory Medicine

Context: Dengue is the most common mosquito-borne viral illness in humans and transmitted by aedes aegypti. Infection may be asymptomatic or present with a mild febrile illness to a life-threatening shock syndrome and diagnosed by virological tests, serological tests, and complete blood count. Aim: The present study was undertaken to evaluate the role of red cell and platelet indices to assess disease activity and severity of dengue infection. Material and Methods: The present study was conducted at a tertiary level teaching hospital in Central Gujarat, India from November 2019 to August 2021.100 dengue positive cases and 100 controls (dengue negative case) were consecutively sampled. Epidemiological, clinical data and complete blood count were collected from online and offline registers of the Central Diagnostic Laboratory. Chi square test, independent sample T – test and Karl pearson coefficient of correlation were used for statistical analysis. Results: Dengue cases have frequent...

Role of Mean Platelet Volume in Dengue Fever -A Prognostic Marker

https://www.ijrrjournal.com/IJRR\_Vol.4\_Issue.6\_June2017/Abstract\_IJRR0012.html, 2017

Introduction: Dengue Fever (DF) has a virus infective etiology caused by an arbovirus. This virus is spread by Aedes mosquitoes. These results in two complications such as Dengue Haemorrhagic Fever (DHF) and in its severe form Dengue Shock Syndrome (DSS) which can threaten the patient's life mainly through high vascular permeability and shock. Due to the rise in the spread of arboviral infection, medical care services are persistently struggling to improve patient management and appropriate steps going on to control vector transmission. The transfusion of platelets is indicated for the thrombocytopenic patients both as prophylaxis as well as treatment of haemorrhage. Platelet count and MPV are strongly associated with prognosis in critically ill patients. Mean platelet volume (MPV) is considered as a valuable marker in predicting the inflammatory process and disease activity. Even after the transfusion of platelets, few patients do not show the appropriate increase in platelet count. Aims and objectives: 1. To assess the role of mean platelet volume in dengue fever. 2. To determine the incidence of dengue fever in various age groups. Materials and methods: Platelet count and Mean platelet volume (MPV) are calculated using automated haematology analyzer. Results: Out of 68 serologically diagnosed dengue cases, the maximum percentage of patients were in the age group of 20 to 40 years (47.05%) followed by 60 years and above (20.58%) with male to female ratio of 1.8:1. Majority of the patients had platelet count ranged from 20000/µL to 40000/ µL (44.11%) followed by more than 60000/µL (25%). Patients who were critically ill (12 patients) showed MPV higher when compared to other patients. Conclusion: Platelet transfusion plays important role in dengue fever yet few patients failed to improve clinically. Though many patients showed improvement in MPV value and total platelet count, few patients did not show much clinical improvement. The underlying causes for failure were bleeding manifestations and immune mediated destruction of platelets. Simply transfusion of platelets to these patients does not make the clinical improvement. Thus identifying the response of platelet transfusion by assessing the MPV value which helps the clinicians to assess the prognosis of patients,