Study of Serum Alanine Transaminase: Serum Lactate Dehydrogenase Ratio for Typhoid Hepatits (original) (raw)
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Significance of Alanine Transaminase in Determining Drug Efficacy in Typhoid Hepatitis
Asian Journal of Biomedical and Pharmaceutical Sciences, 2012
Objectives: Abnormal liver enzyme levels might be observed with typhoid fever indicating liver involvement. Although, jaundice is unusual and infrequently reported in children, it declares the occurrence of complication. The aim was to evaluate the efficacy of some anti-typhoid drugs in typhoid hepatitis in children through measuring liver transaminase enzymes levels. Patients and Methods: 123 typhoid pediatric patients with high liver transaminase enzymes levels were participated and randomly allocated into 3 groups receiving cefixime (20 mg/kg/day), chloramphenicol (50 mg/kg/day) and amoxicillin (100mg/kg/ day) for two weeks. The obtained data were analyzed using SPSS (version 12) and were expressed as mean ± SEM and the difference among means has been analyzed by student's t test. Results: 64.8% had higher levels of Alanine transaminase than Aspartate transaminase while only 12.5% showed the opposite. At the end of the treatment; 68.3% had normally-returned alanine transaminase level before aspartate transaminase level, while 31.7% had the opposite. Conclusion: Estimation of alanine transaminase level in typhoid hepatitis during and after treatment gives a clue for the efficacy of the used drugs.
Hepatic Dysfunction and Biochemical Abnormalities in Typhoid Patients
Asian journal of multidisciplinary studies, 2018
Objective: To study biochemical abnormalities and hepatic dysfunction in typhoid patients. Place and Duration of Study: This study was carried out from March to July 2018 in Lahore. Materials and Methods: 200 patients were included in the study having typhoid fever and 100 individuals as control group. Positive serum of typhoid was taken with evident agglutination at 1:320. For performing widal test, the rising titre was used in order to avoid false positive. The patients had positive Typhi dot. Furthermore, the fever pattern was step ladder rising.The chemical analyser performed Aspartate transaminase (AST), Alanine transaminase (ALT), Bilirubin and serum Albumin on samples of these patients. Results: 55 patients of the study were having increased ALT, value of mean was 99 ± 11.533 U/L. half of the patients were having increased AST and value of the mean of 111 ±14.454 U/L. 20% patients were having increased Serum bilirubin with mean 4.9 ±2.351 mg/dl. 26% patients had low Serum alb...
A Study of the Clinical and Biochemical Profile of Acute Viral Hepatitis
Aim: This study was performed to compare the clinical, biochemical and etiological properties of acute viral hepatitis (AVH) and to compare clinical and laboratory parameters of faeco-orally transmitted hepatitis: hepatitis A+ hepatitis E (A+E) with hematologicaly transmitted hepatitis: Hepatitis B, C, D (B+C+D). Material and Methods: Biochemical and clinical data were collected from 40 patients with AVH. They were tested for hepatitis B surface antigen (HBsAg), IgM anti-Hepatitis A virus (Immunoglobulin M HAV), IgM anti-HBc (Immunoglobulin M hepatitis B core antigen), IgM anti-hepatitis D (Immunoglobulin M HDV), or IgM anti-hepatitis C (Immunoglobulin M HCV). Finally X 2 test was used to analysis of data. Results: Most patients were young adults and presented with jaundice and other constitutional features, although anicteric hepatitis was also seen. Hepatitis E was the most common AVH. Malaise, fever, icterus, vomiting and nausea were significantly more in Hepatitis A +E compared with Hepatitis B + C in acute course. Serum bilirubin both total and direct was significantly elevated in hepatitis A + E compared with Hepatitis B + C in acute course. Conclusions: Hepatitis E was the most common AVH .There were some differences in clinical and laboratory findings regarding to the etiology but it does not necessarily distinguish one cause of hepatitis from another.
Aim: Typhoid fever is a life-threatening infection caused by the bacterium Salmonella enterica serotype Typhi occurring frequently in underdeveloped regions of the world due to overcrowding and poor sanitation. However, the biochemical changes induced by typhoid fever have not been fully understood as a guide to finding a possible counter measure to combating the disease. The study was designed to determine the biochemical changes associated with typhoid disease. Place and Duration of Study: The study was carried out at the Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Nigeria, in the year 2014. Methods: The study evaluated kidney electrolyte, lipid profile, liver marker enzymes in the serum of typhoid patients. 140 subjects were recruited for this study, 70 of which were normal individual control group and 70 individual with typhoid test group with age range of 18 to 28 years. Blood samples were analyzed to determine the lipid profile, kidney function and liver enzyme concentration spectrophotometrically. Results: Urea and creatinine concentration in typhoid patients significantly increased (P = .05) when compared with the control group. Sodium ion, potassium ion, chloride ion and bicarbonate ion significantly decreased (P = .05) when compared to the control group. Result for liver function test revealed a significant increase in the concentration of AST, ALT and ALP in test group. HDL, LDL, Cholesterol, triacyglycerols and VLDL concentration significantly increased (P = .05) in typhoid patients when compared with normal individuals. Concentration of total protein, albumin, globulin significant decrease (P = .05) in test group when compared with the control group. Conclusion: The study gave a clear indication of the changes induced by typhoid fever in humans. This study also revealed some physiological and biochemical conditions in typhoid patients that varies from normal individual, which explains the influence of typhoid morbidity.
Comparative Study on Serum Enzyme Levels in Cirrhosis of Liver and Alcoholic Liver Disease
Patients with chronic liver diseases are asymptomatic or have only vague non-specific symptoms. Effective medical treatments for chronic liver disease (before cirrhosis is established) are becoming increasingly available and since abnormal LFTs may be the only indication of this diseases. Aims: comparative study on serum Enzyme levels in various liver diseases. Discussion: serum Alkaline phosphatase(ALP), Gamma Glutamyl transferase (Gamma GT), Alanine and Aspartate amino transferases were estimated in viral Hepatitis, Alcoholic liver diseases, Obstructive jaundice, cirrhosis of the liver. It was observed that obstructive jaundice shows higher levels of ALP levels followed by alcoholic liver disease, viral hepatitis, cirrhosis of liver. Viral hepatitis shows higher rise of SGOT, SGPT levels, followed by alcoholic liver disease, obstructive jaundice, and cirrhosis of liver. Gamma Glutamyl transferase enzymes highest levels are seen in alcoholic liver disease. Conclusion: These enzymatic variations are useful to diagnose the disease and classify them according to etiology.
Medicina
The aim of this study was to characterize the biochemical, virological and histological profile of patients with HCV infection and persistently normal alanine aminotransferase levels (PNALT) in order to discriminate between normal liver and chronic hepatitis. Twenty eight anti-HCV positive patients with PNALT were studied. Twelve (42.9%) patients showed normal liver while 16 (57.1%) had chronic hepatitis. In patients with normal liver, the mean of ALT level differed from patients with chronic hepatitis (16.3 IU/L versus 25.6 IU/L, p 0.000089). By considering different ALT values as upper normal limit, sensitivity, specificity, positive and negative predictive values were calculated and the value of 18 IU/l showed 88, 90, 94 and 82%, respectively, in predicting chronic hepatitis. In conclusion, patients with normal liver had lower ALT levels than those with chronic hepatitis and by establishing 18 IU/L as a new upper limit of normal ALT value, it was possible to differentiate normal ...
IP innovative publication pvt. ltd, 2019
Introduction: Patients with infective hepatitis are faced with danger of pancreas getting affected. This can be reflected as increased serum amylase values. Objective: To study serum amylase in patients with infective hepatitis. Materials and Methods: Present study was cross sectional study. Two groups of patients were compared. One group was with infective hepatitis and the other group was without infective hepatitis. This was a hospital based comparative study. Serum amylase was determined using modified Huggins and Russel method. Results: The mean serum amylase value was 70.4 units among cases and it was 22.8 among the controls. The difference in the values was found to be statistically significant. It was found that the mean serum amylase value was 22.8 in the age group of 20-34 years which slightly increased in the age group of 35-49 years and again decreased slightly above the age of 50 years. Hence the difference was not found to be statistically significant. Conclusion: There is a significant increase in the serum amylase levels values among patients with infective hepatitis.
Delta Medical College Journal, 2015
Background: In recent years the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) in patients of chronic liver disease (CLD) of various origins has gained much attention. This variable is readily available, easy to interpret, and inexpensive and the clinical utility of the AST/ALT ratio in the diagnostic workup of patients with CLD is quite promising. Objective: The present study was designed to find out the link between aminotransferase (AST/ALT) ratio with commonly measured biochemical parameters of liver function tests in CLD of viral origin. Materials and method: This cross sectional study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. With aseptic precaution 5 mL venous blood was collected from each subject and common liver function tests (serum AST, ALT, AST/ALT ratio, al...