Ionic Liquid-Based Green Emulsion Liquid Membrane for the Extraction of the Poorly Soluble Drug Ibuprofen (original) (raw)
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Chemical reviews, 2017
Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid-liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to...
Talanta, 2015
A rapid, sensitive and efficient analytical method based on the use of ionic liquids for determination of non-steroidal anti-inflammatory drugs (NSAIDs) in water samples was developed. High-performance liquid chromatography equipped with a diode array and fluorescence detector was used for quantification of ketoprofen, ibuprofen and diclofenac in tap and river water samples. This new method relies on the use of two ionic liquids with multiple functionalities: one functions as an extraction solvent (1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF 6 ]), and the other changes the polarity in the aqueous medium (1-butyl-3-methylimidazolium tetrafluoroborate, ([BMIM][BF 4 ]). Factors such as the type and volume of the ILs and dispersive solvent, sample volume, and centrifugation time were investigated and optimized. The optimized method exhibited good precision, with relative standard deviation values between 2% and 3%, for the three NSAIDs. Limits of detection achieved for all of the analytes were between 17 and 95 ng mL À 1 , and the recoveries ranged from 89% to 103%. Furthermore, the enrichment factors ranged from 49 to 57. The proposed method was successfully applied to the analysis of NSAIDs in tap and river water samples.
Use of ionic liquids as 'green'solvents for extractions
Journal of Chemical Technology and …, 2005
This review summarizes recent applications of ionic liquids (ILs) as 'green' solvents in extractions of a variety of substances, including metal ions, organic and bio-molecules, organosulfur from fuels, and gases. ILs could also be used along with another 'green' technology, supercritical fluid extraction (SFE), for a more effective separation of products from ILs. In addition to their environmentally-benign feature, ILs have other favorable properties over organic solvents used for extraction, such as adjustable hydrophobicity, polarity and selectivity.
Journal of Separation Science, 2012
Two imidazolium supported ionic liquid phases (SILPs) containing different anions, trifluoromethanesulphonate [CF 3 SO 3 − ], and tetrafluoroborate [BF 4 − ], were synthesized and evaluated as solid-phase extraction sorbents for extracting acidic pharmaceuticals from aqueous samples under strong anion-exchange conditions, which include an effective cleanup of the sample. The best SILP material [MI + ][CF 3 SO 3 − ] was selected and successfully applied to the determination of acidic pharmaceuticals in different types of water samples (river water and effluent wastewater). The results were then compared to the previously synthesized SILP material based on [MI + ][CF 3 COO − ] and the commercially available Oasis MAX sorbent.
Ionic Liquids: Recent Journey Through Chromatographic Separation
Journal of Advanced Scientific Research
Ionic liquids (ILs), despite some of their crucial disadvantages, have been established to be the apt and relevant replacement of the volatile organic compounds (VOCs) in the industrial and academic sectors as solvents. Recent investigations on thriving multifaceted applications of ionic liquids have unleashed that they are really among beneficial “environmentally-benign” solvents as far as their impact on the ecosystem is concerned. This caused them to be an exciting and lucrative domain to explore in a wider fashion and many of the leading research groups are involved in the manifestation of their inherent undisclosed legacy. While exploring the efficacy of ILs, it was found that ILs or IL-based mixed solvent systems were very good alternative of conventional solvents and could act as mobile/stationary phases or additives in gas chromatography (GC), multidimensional gas chromatography (MDGC), inverse gas chromatography (IGC), high performance liquid chromatography (HPLC) and capil...
The a priori design and selection of ionic liquids as solvents for active pharmaceutical ingredients
Chemistry - A European Journal, 2017
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Advances of Ionic Liquids in Analytical Chemistry
Analytical chemistry, 2018
Ionic liquids and polymeric ionic liquids in solid-phase extraction 16 Ionic liquids and polymeric ionic liquids in solid-phase microextraction Liquid-phase (micro)extraction 18 Ionic liquids and magnetic ionic liquids in dispersive liquid-liquid 19 microextraction 20 Ionic liquid dispersive liquid-liquid microextraction 21 Magnetic ionic liquid dispersive liquid-liquid microextraction 22 Ionic liquids and magnetic ionic liquids in single-drop microextraction 23 Ionic liquids in hollow fiber liquid-phase microextraction 24 Two phase ionic liquid-hollow fiber liquid-phase microextraction 25 Three phase ionic liquid-hollow fiber liquid-phase microextraction 26 Ionic liquids and magnetic ionic liquids in aqueous biphasic systems 27 Chromatographic and electrophoretic separations 28 Gas chromatography 29 Monocationic ionic liquid-based stationary phases 30 Di-and polycationic ionic liquid-based stationary phases 31 Polymeric ionic liquid-based stationary phases 32 Metal-containing ionic liquid-based stationary phases 33 Commercial ionic liquid-based stationary phases 34
Enhanced extraction of antioxidants from aqueous solutions by ionic liquids
Separation and Purification Technology, 2017
In this work, the extraction behavior of the three antioxidants, gallic acid (GA), vanillic acid (VA) and syringic acid (SA) by a series of hydrophobic ionic liquids (ILs) was investigated. The experimental results indicated that the extraction ability of the ILs highly depended on their chemical structures and the hydrophobicity of the three acids. For the ILs with perchlorate (ClO 4 À) as anion, the introduction of hydroxyl group on the cation improved significantly the extraction ability of ILs for GA. For the extraction of VA and SA, the hydrophobic interaction between ILs and VA or SA should also be considered. Thermodynamic analysis confirmed that hydrogen bonding was the main driving force underlying the transfer of the three acids from water to the IL phase. The three acids and ILs could be recovered and recycled, respectively by taking the advantage of pH dependence of the extraction efficiencies. These results suggested the ILs containing perchlorate anion exhibited potential applications in extraction of the three antioxidants from aqueous phase.
The present work focussed on application of the environmental friendly 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide ([BMIM] + [Tf 2 N] − ) ionic liquid for the separations of (alkane/aromatic), (alkane/alk-1-ene), (cycloalkane/aromatic) and (water/alkan-1-ol) using gas-liquid chromatography (GLC) technique. In this reason the activity coefficients at infinite dilution, γ 13 ∞ , for 31 organic solutes (alkanes, cycloalkanes, alkenes, alkynes, aromatics, alkanol and ketones) and water in ionic liquid were measured at temperatures of (323.15, 333.15, 343.15, 353.15 and 363.15) K. Stationary phase loadings of (42.83 and 68.66) % by mass were used to ensure repeatability of measurements. Density and viscosity values were measured to confirm the purity of ionic liquid. Partial molar excess enthalpies at infinite dilution, ΔH 1 E,∞