Tuberculosis presentation and outcomes in elderly Hispanics from Tamaulipas, Mexico (original) (raw)
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PeerJ, 2020
Tuberculosis (TB) represents a health problem in Colombia, and its control is focused on the search for contacts and treatment of TB cases underscoring the role of latent tuberculosis infection (LTBI) as a reservoir of Mycobacterium tuberculosis. The burden of LTBI in Colombia is unknown. We aimed to estimate the prevalence of LTBI and identify the associated risk factors. In this cross-sectional study, we recruited participants from four health care centers in Cali, Colombia. The participants were eligible if they were aged between 14 and 70 years, and all participants answered a survey evaluating their medical history and sociodemographic and lifestyle factors. LTBI status was based on tuberculin skin test (TST) positivity using two thresholds: ≥10 mm (TST-10) and ≥15 mm (TST-15). The magnitude of the associations between independent factors and dependent outcomes (LTBI status and TST induration) were evaluated by logistic regression and generalized linear models, respectively. A ...
Risk factors associated with tuberculosis mortality in adults in six provinces of Argentina
Medicina, 2017
Tuberculosis (TB) remains a cause of illness and death across the world, especially in developing countries and vulnerable population groups. In 2013, 1.5 million died from the disease worldwide. In Argentina, the largest proportion of TB-related deaths occurred in the northern provinces. Several international studies reported that TB mortality was related to the presence of certain comorbidities and socio-demographic characteristics. Our aim was to investigate the main risk factors associated with TB mortality in adults from six provinces in Argentina, especially those with higher TB mortality rates. A retrospective case-control study was conducted. It included all patients of =18 years with clinical and/or bacteriological TB diagnosis who underwent treatment from January 1st, 2012 to June 30th, 2013. Socio-demographic, clinical and bacteriological variables were surveyed. Information on 157 cases and 281 controls was obtained. Patients reported as deceased to the TB Control Progra...
Introduction: Tuberculosis (TB) is an extreme relevance pathology to the Public Health due to the morbidity and mortality high rates, with emphasis on the older population. The bacillus characteristic is intracellular, so a competent immune system must be needed to fight it through the cellular mechanisms. Methods: Cross-sectional, documentary and analytical study based on the review of 128 medical records from the patients, who aged 60 years old or older at the time of the care due to TB or its complications from January 2006 to December 2016. Results:The death prevalence was 44.5%. The bivariate analysis revealed that the men died 30% more than the women (PR = 1.3; CI 95% 0.81 - 2.07). In regard to the outcome (death and discharge), there was a statistical significance related to: a) clinical and epidemiological characteristics: Outpatient care (p = 0.002), ICU (p <0.001), Coma (p = 0.005), Hospitalization days (p <0.001 ), Treatment Adherence (p = 0.006), Treatment Abandonment (p = 0.036); b) risk and some associated factors: Malnutrition (p = 0.018), Hypertension (p = 0.024), HIV / AIDS (p = 0.010); The Poisson regression model for the outcome death / discharge shows ICU admission (p<001), Treatment adherence (p=002), Procedence origin (p=046). Conclusion: The study showed different risk factors toward the death occurrence from the tuberculosis amog the older people and illustrates the relevance of a continuous surveillance in order to monitor the TB.
Predictors of death from pulmonary tuberculosis: the case of Veracruz, Mexico
The International Journal of Tuberculosis and Lung Disease
To identify factors (particularly social, economic and cultural), associated with the risk of death from pulmonary tuberculosis in Mexico. A case-control study of patients receiving medical attention from the official health services of Veracruz, Mexico. Cases were deaths from pulmonary tuberculosis in 1993. Controls were survivors randomly selected from the State Tuberculosis Case Registry. Next of kin provided information for both cases and controls. Multivariate analysis of 161 cases and 161 controls showed an increased risk of dying for those patients who withdrew from treatment (odds ratio [OR] = 3.52), who were refused medical attention during some period of time in any health center (OR = 4.45), and who had a concomitant disease at the time of diagnosis (OR = 2.62). A linear trend with age was observed (OR = 1.02 per year), as well as a lower risk for those patients who were compliant with treatment and optimistic about surviving the disease (OR = 0.17). The risk of death was...
Background Tuberculosis (TB) remains a public health problem in Mexico while the incidence of diabetes mellitus type 2 (DM) has increased rapidly in recent years. Objective To describe the trends of incidence rates of pulmonary TB associated with DM and not associated with DM and to compare the results of treatment outcomes in patients with and without DM. Materials and Methods We analysed the National Tuberculosis Registry from 2000 to 2012 including patients with pulmonary TB among individuals older than 20 years of age. The association between DM and treatment failure was analysed using logistic regression, accounting for clustering due to regional distribution. Results In Mexico from 2000 to 2012, the incidence rates of pulmonary TB associated to DM increased by 82.64%, (p <0.001) in contrast to rates of pulmonary TB rate without DM, which decreased by 26.77%, (p <0.001). Patients with a prior diagnosis of DM had a greater likelihood of failing treatment (adjusted odds ratio, 1.34 (1.11–1.61) p <0.002) compared with patients who did not have DM. There was statistical evidence of interaction between DM and sex. The odds of treatment failure were increased in both sexes. Conclusion Our data suggest that the growing DM epidemic has an impact on the rates of pulmonary TB. In addition, patients who suffer from both diseases have a greater probability of treatment failure.
Public Health Reports, 2017
Objectives: The objectives of our study were (1) to determine risk factors associated with tuberculosis (TB)–specific and non–TB-specific mortality among patients with TB and (2) to examine whether risk factors for TB-specific mortality differed from those for non–TB-specific mortality. Methods: We obtained data from the National Tuberculosis Surveillance System and included all patients who had TB between 2009 and 2013 in the United States and its territories. We used multinomial logistic regression analysis to determine the adjusted odds ratio (aOR) of each risk factor for TB-specific and non–TB-specific mortality. Results: Of 52 175 eligible patients with TB, 1404 died from TB, and 2413 died from other causes. Some of the risk factors associated with the highest odds of TB-specific mortality were multidrug-resistant TB diagnosis (aOR = 3.42; 95% CI, 1.95-5.99), end-stage renal disease (aOR = 3.02; 95% CI, 2.23-4.08), human immunodeficiency virus infection (aOR = 2.63; 95% CI, 2.0...
Association of Pulmonary Tuberculosis and HIV in the Mexican Institute of Social Security, 2006-2014
PLOS ONE, 2016
Background Tuberculosis and HIV remain a public health problem in developed countries. The objective of this study was to analyze the incidence trends of pulmonary TB and HIV comorbidity and treatment outcomes according to HIV during the period 2006 to 2014 in the Mexican Institute of Social Security. Methods Analyzed data from this registry including pulmonary tuberculosis patients aged 15 years and older who had been diagnosed during the years 2006 to 2014 in the Mexican Institute of Social Security. The outcomes that we use were incidents rate, failure to treatment and death. Regression models were used to quantify associations between pulmonary tuberculosis and HIV mortality. Results During the study period, 31,352 patients were registered with pulmonary tuberculosis. The incidence rate observed during 2014 was 11.6 case of PTB per 100,000. The incidence rate for PTB and HIV was 0.345 per 100,000. The PTB incidence rate decreased by 0.07%, differences found in the PTB incidence rate by sex since in women decreased by 5.52% and in man increase by 3.62%. The pulmonary TB with HIV incidence rate decreased by 16.3% during the study period (In women increase 4.81% and in man decrease 21.6%). Analysis of PTB associated with HIV by age groups revealed that the highest incidence rates were observed for the 30 to 44 years old group. Meanwhile, the highest incidence rates of PTB without HIV occurred among the 60 and more years old individuals. We did not find statistically significant differences between treatment failure and PTB patients with HIV and without HIV. The treatment failure was associated with sex and the region of the patient. We found a PLOS ONE |
Morbidity Trends and Risk of Tuberculosis: Mexico 2007–2017
Canadian Respiratory Journal, 2019
Background. To know the current status of the epidemiological and geographic distribution of tuberculosis and its complication meningeal tuberculosis in Mexico, this work analyzes national surveillance data (ten years) issued by the General Directorate of Epidemiology (GDE).Methods. An observational and retrospective analysis of monthly and annual reports of pulmonary and meningeal tuberculosis cases from January 2007 to December 2017 was performed on the annual reports issued by the GDE in Mexico. The number of cases and incidence were classified by year, state, age group, gender, and seasons.Results. A national case distribution map of pulmonary and meningeal tuberculosis incidence was generated. During this period, a total of 184,003 and 3,388 cases were reported with a median of 16,727.5 and 308 cases per year for pulmonary and meningeal tuberculosis diseases, respectively. The number of cases and incidence of pulmonary and meningeal tuberculosis per year showed that male gender...
Tuberculosis and comorbidities in urban areas in Argentina. A gender and age perspective
Biomédica, 2018
Introducción. La tuberculosis continúa siendo un importante problema de salud en el mundo, con una incidencia de más de 10 millones de casos en el 2015. Hay factores que modifican el riesgo de desarrollar la enfermedad luego de contraer la infección, así como su forma de presentación.Objetivo. Determinar las principales comorbilidades y características demográficas, clínicas y microbiológicas de pacientes adultos con tuberculosis en Argentina, mediante un análisis desde la perspectiva de sexo y edad.Materiales y métodos. Se llevó a cabo un estudio transversal en hospitales de referencia para pacientes de áreas urbanas con tuberculosis. Se incluyeron pacientes de 15 años o más con tuberculosis pulmonar o extrapulmonar, confirmada bacteriológicamente y en tratamiento hospitalario o ambulatorio, y también, pacientes sin confirmación bacteriológica, pero con características clínicas y radiológicas indicativas de tuberculosis. El período de estudio fue del 1º de agosto de 2015 al 31 de a...