Targeting G protein–coupled receptor kinases to G protein–coupled receptors (original) (raw)

Frontiers in Pharmacology

G protein-coupled receptor kinases of the GRK4 subfamily phosphorylate inactive GPCRs

The Journal of biological chemistry, 2015

The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling

Petronila García

Biochimica Et Biophysica Acta-biomembranes, 2007

GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation

Raphael Silvanus Haider

Nature Communications, 2022

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

Raphael Silvanus Haider

2021

Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology

Ahmed Bayoumi

Biomolecules & therapeutics, 2017

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

Pharmacology & Therapeutics, 2012

G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor

Seungkirl Ahn

Science Signaling

Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis*

Stéphane Laporte

Journal of Biological Chemistry, 2001

G protein coupled receptors as drug targets: the role of beta-arrestins

K. Pfleger

Endocrine, metabolic & immune disorders drug targets, 2008

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Laurence Dupuy

Molecular Systems Biology, 2012

Editorial: G Protein-Coupled Receptor Kinases (GRKs) and β-Arrestins: New Insights Into Disease Regulators

Martin Michel

Frontiers in Pharmacology

Novel aspects of G-protein-coupled receptor signalling ? different ways to achieve specificity

Gunnar Schulte

Acta Physiologica, 2007

Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases

Catalina Ribas

Cellular Signalling, 2003

arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo

Stuart Maudsley

Molecular endocrinology (Baltimore, Md.), 2013

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

2003

Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex

Thomas Bourquard, Eric Reiter

Scientific reports, 2015

Structural insight into G protein-coupled receptor signaling efficacy and bias between Gs and β-arrestin

ACS Pharmacology & Translational Science

Molecular Mechanisms of G Protein-Coupled Receptor Desensitization and Resensitization

B. Giros

Life sciences, 1998

-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

Proceedings of the National Academy of Sciences, 2003

Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2

Rocío Alcántara Hernández

European Journal of Cell Biology, 2018

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

Proceedings of the National Academy of Sciences of the United States of America, 2017

Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms

Molecular Pharmacology, 2008

The ins and outs of G protein-coupled receptor trafficking

Jeffrey Benovic

Trends in Biochemical Sciences, 2003

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

Stephen Ferguson

Journal of Biological Chemistry, 1998

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Daniel Mayer

Nature Communications

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

Stefano Marullo

Proceedings of the National Academy of Sciences of the United States of America, 2015

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

Journal of Biological Chemistry, 2014