Primary neuroendocrine tumor (carcinoid tumor) of the testis: a case report with review of literature (original) (raw)

Primary carcinoid tumor of the bilateral testis associated with carcinoid syndrome

International Journal of Urology, 2004

Carcinoid tumors derived from neuroendocrine cells can release serotonin and other vasoactive substances into the systemic circulation, resulting in carcinoid syndrome. Testicular carcinoid, a rare disease accounting for less than 1% of all testicular neoplasms, rarely manifests symptoms of carcinoid syndrome. We describe a case of carcinoid syndrome arising from a primary testicular carcinoid tumor. A 21-year-old male patient presented with facial flushing and diarrhea for 5 years. He had an enlarged left testis and a 1-cm, ill-defined, hard, non-tender mass in his right testis. His 24 h urinary excretion of 5-hydroxyindoleacetic acid was elevated (16.1 mg/day). Somatostatin receptor scintigraphy correlated with carcinoid tumor in both testes. Following bilateral orchiectomy, the patient's facial flushing and diarrhea disappeared.

Primary neuroendocrine tumor of the testis

Urology Annals, 2014

Testicular neuroendocrine tumor is rare. It accounts for less than 1% of all testicular neoplasms. More than 60 cases have been published in the literature. A 27-year-old man presented with left testicular mass and underwent radical orchidectomy. Histological examination showed neuroendocrine tumor, confirmed by immunohistochemistry and electron microscopy. The patient showed no evidence of metastasis over 1-year follow-up post-orchidectomy in spite of extensive tumor necrosis.

Primary carcinoid or sex cord-stromal tumor of the testis: A case report

Caspian Journal of Internal Medicine, 2023

Background: Carcinoid tumors of the testis are rare and orchiectomy is the preferred treatment. This type of testis tumors is rare and their differentiation from sex cord-stromal tumors is difficult. Case presentation: A 29-year-old man presented with right testicular mass and underwent radical orchidectomy. Histological examination showed neuroendocrine tumor, confirmed by immunohistochemistry and electron microscopy (Ethic code: IR.MUMS.REC.1400.237). Conclusion: Primary testicular neuroendocrine tumor is very rare. It is crucial to submit the entire gross specimen for histopathologic examination to rule out an existing of other germ cell elements. Our patient had a well-differentiated carcinoid tumor and after two years of follow-up (every three months), there was no recurrence or metastasis.

Primary carcinoid tumor of the testis: case report

Chang Gung medical journal, 2002

Carcinoid tumor of the testis is exceedingly rare. Most carcinoid tumors occur in the appendix or ileocecal region (85%), while others are found in the lung, liver, and genitourinary tract (15%). A primary carcinoid testis tumor may originate from argentaffin or Kulchitsky's cells, which are located in the Lieberkuhn crypt. Preoperative ultrasound may show a solid, hypoechoic, well-defined margin mass combined with calcification or a cyst. Differential diagnosis of the ultrasound appearance is testicular tumor (teratoma/embryonal cell carcinoma), epidermoid tumor, tuberculous epididymo-orchitis, and the result of trauma. Radical orchiectomy remains the main treatment for a carcinoid testis tumor. Grossly, surgical removal of the tumor presents with a solid mass, tan to white in color. Immunohistochemical study shows that tumor cells are diffusely reactive to antibodies to keratins AE1 and AE3, chromogranin-A, neuron-specific enolase (NSE), and synaptophysin. A pure primary testi...

Primary Carcinoid Tumour of Testis - A Rare Case Report

Carcinoid tumour of the testis is very rare (0.23 %). Most carcinoid tumours occur commonly in the appendix or ileocaecal region (85%), while less common (15%) sites are lung, liver, and genitourinary tract. Carcinoid tumours that occur outside the gastrointestinal tract are usually metastatic. Pure primary testicular carcinoid tumour has good prognosis and treated as a benign lesion, while metastatic carcinoid tumour has a poor prognosis whatever may be site of primary tumour. We report a case of primary carcinoid tumour of the testis and review the literature. Detailed work-up of patient by USG, chest x-ray, GI contrast study and CT scan of the abdomen did not reveal any tumour at other sites and 24 hour urinary 5-HIAA estimation was normal. Keywords: primary carcinoid, 5-HIAA, testis tumour INTRODUCTION Carcinoid tumours (85%) occur commonly in the appendix or ileocaecal region and may present in extra intestinal sites i.e. lung, liver, respiratory tract, uterus, ovary and breast...

A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour

Chirurgia

Introducere: Lucrarea îşi propune să prezinte cazul rar al unui teratom testicular combinat cu tumoră neuroendocrină şi să sublinieze dificultatea diagnosticului clinic, paraclinic, a posibilităţilor terapeutice şi evolutive ale acestor pacienţi. Prezentare caz: Pacienţii cu tumori neuroendocrine testiculare reprezintă o raritate, până în 2017 erau 22 cazuri raportate în bazele de date internaţionale. Cazul operat în clinica noastră prezenta o asociere de teratom testicular cu tumoră neuroendocrină. Vârsta de diagnosticare a fost de 39 de ani, pacientul fiind internat în Clinica de Chirurgie cu o tumoră abdominală nedureroasă şi prezentând o masă tumorală testiculară voluminoasă. Markerii tumorii serice (β-gonadotrofina corionică umană, α-feto proteina şi lactat dehidrogenaza) au fost în limite normale. Metastazele pulmonare şi osoase au fost diagnosticate prin CT. Diagnosticul a fost tranşat prin teste de imunohistochimie după orhiectomie şi puncţie medulară. Concluzii: Diagnosticul carcinoidelor testiculare se bazează pe studiul imunohistochimiei. Tratamentul de alegere pentru aceste tumori este orchiectomia radicală. Chimioterapia a determinat reducerea determinărilor pulmonare şi osoase şi dispariţia metastazelor ganglionare. Cuvinte cheie: cancer testicular, tumori neuroendocrine

Primary Carcinoid Tumor of the Testis: A Case Report and Review of the Literature

Case Reports in Urology

Carcinoid tumors usually arise in the gastrointestinal tract. Immunocytohistochemical and radiologic studies are important in detecting the primary tumor site. Primary carcinoid tumors of the testis are particularly rare with a high malignant potential warranting long-term follow-up. We present the case of a primary carcinoid tumor of the testis with long-term surveillance.