Role of Inositol Triphosphate Receptor in Cancer and Its Targeting Through Autophagy (original) (raw)

Multi-Targeted Approach to Treatment of Cancer, 2014

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to IP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription and secretion to learning and memory. These receptors regulate the transfer of Ca2+ from ER to mitochondria via transport protein on mitochondrial membrane which regulates cellular bioenergetics. IP3R/Ca2+ release channel is most ubiquitously expressed which can enhance or inhibits autophagic process to induce cell death of cancer cells. There are evidences linking calcium homeostasis to the regulation of apoptotic and autophagic cell deaths. The present chapter will focus on the inositol triphosphate receptor and how this can be used as a tool to target cancer through autophagy.

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