Evidence for bile acid-evoked oscillations of Ca2(+)-dependent K+ permeability unrelated to a D-myo-inositol 1,4,5-trisphosphate effect in isolated guinea pig liver cells (original) (raw)

Two types of oscillations in intracellular calcium levels were analyzed in isolated guinea pig liver cells, evoked by the bile acid taurolithocholic acid 3-sulfate (TLC-S) and hormone agonists like angiotensin II. The study reveals that while both TLC-S and these agonists can activate Ca2+-dependent K+ permeability and induce oscillations, the effects of TLC-S are not mediated by the D-myo-inositol 1,4,5-trisphosphate signaling pathway. Notably, type I oscillations induced by TLC-S occur independently of InsP3, indicating a distinct mechanism deriving from internal calcium store properties.