A novel approach to characterizing cell migration (original) (raw)
Cancer cell metastasis has been responsible for the vast majority of cancer-related deaths in the United States. The processes involved in cancer cell metastasis, such as extravasation and intravasation, are driven by cell motility. The conventional method of characterizing cell motility typically involved imaging live cells under a microscope for several hours and tracking cells’ trajectories manually with the help of computer software, and this method is highly inefficient and time-consuming for obtaining cell motility information. This dissertation aims to develop a new method to quantitatively characterize cell motility based on the spatial distribution of cells in clones at a specific time point. A simulation study was first performed to evaluate the correlation between cell spatial distribution in the clones and cell motility. Clonal distributions of cells were generated at the 72 hr time point from computer-simulated cell trajectories based on the PRW model for clone sizes of...
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