From Striking Out to Striking Gold: Discovering that Type VI Secretion Targets Bacteria (original) (raw)

This research highlights the discovery and significance of the type VI secretion system (T6SS) in bacterial interactions. The paper details the journey and methodology undertaken by the Mougous lab at the University of Washington to identify T6S substrates, particularly focusing on the toxic protein Tse2, which is part of a toxin-immunity pair. The findings emphasize the T6SS's role in interbacterial antagonism and its implications in the broader field of microbiology, challenging established notions about bacterial secretory mechanisms.