Abstract 207: Interesterified Fat Rich in Stearic Acid Increases Liver Neutrophil and M1 Macrophage Infiltration and Induces Nonalcoholic Steatohepatitis (original) (raw)

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014

Abstract

Introduction: interesterified fats, rich in saturated fatty acid, have been used by food industry to replace trans. Palmitic acid is the most common dietary fat with known deleterious effects. On the hand stearic acid which is consumed in a low amount, has neutral effect on plasma lipids. Unlike vegetable oils, interesterified fats contain palmitic or stearic acid in the sn-2 position and the positional compositon of triglicerides may regulate its metabolic fate. Thus, the aim of this study was to evaluate the effect on the liver metabolism of the interesterified fats rich in stearic or palmitic fatty acids. Methods: Weaning LDLr-KO male mice were randomly distributed into five groups fed a high fat diet (40% of energy as fat) containing polyunsaturated (PUFA), palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR) or stearic interesterified (STEAR INTER) during 16 weeks. Total plasma cholesterol and triglyceride concentrations, liver total cholesterol, triglyceride...

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