The Severity of Covid- 19 Among Pregnant Women and The Risk of Adverse Maternal Outcome (original) (raw)
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Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Scientific Reports
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newb...
COVID-19 Infection in Pregnancy: A Descriptive Cross-sectional Study
Birat Journal of Health Sciences
Introduction: There is diverse evidence regarding the maternal and fetal effect of coronavirus disease 2019 (COVID-19) in pregnancy. Objectives: The objective of this study was to assess the effect of COVID-19 in mother and fetus during pregnancy. Methodology: A descriptive cross-sectional study was conducted during the second wave of COVID-19 in the Department of Obstetrics and Gynaecology at Birat Medical College Teaching Hospital from April 3 to July 3, 2021. All pregnant women admitted in the antenatal ward were sent real-time reverse transcription polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The patients with RT-PCR confirmed SARS-CoV-2 infection were enrolled in the study and followed up until discharged. Results: The COVID-19 positivity rate was 18.0%.The mean age was 24.38 years. Majority of the patients were asymptomatic (79.7%) Among symptomatic patients, 73.3% had fever and respiratory symptoms and 95.9% of...
COVID-19 and pregnancy- review of cases from a tertiary public hospital in Mumbai
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Background: In December 2019 a novel strain of coronavirus, was first isolated by the Chinese Center for Disease Control and Prevention. This strain connected to the cluster of acute respiratory illness cases from Wuhan, China was later officially named as severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). On 30th January 2020, WHO declared the outbreak of SARS-Cov-2 a public health emergency of international concern, and on 11th March 2020 declared it to be a pandemic. Pregnant women are known to be at higher risk of severe morbidity and mortality from respiratory infections such as influenza and SARS, making a strong case for pregnant women to be considered an at-risk population for COVID-19. This study aimed to assess the clinical picture, obstetric outcome and neonatal outcome in COVID positive pregnant cases.Methods: We did a retrospective observational cohort study in the department of Obstetrics and Gynecology at a tertiary teaching hospital in Mumbai.Results: In t...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: By the end of 2019, WHO had identified COVID-19 disease as a public health emergency. Research has focused on the impact of SARS-CoV-2 infection during pregnancy, including symptoms, disease severity, risk of vertical transmission, and perinatal and neonatal prognosis. Methods: This was a cross sectional prospective observational study, conducted at Gynae and Obstetric Department, in Bangabandhu Sheikh Mujib Medical University, between July 2020 to August 2021. 75 pregnant women who tested positive for COVID-19 were included in this study. Results: Most of the patients 29(38.7%) were aged 25-29 years. Majority 96% (72) of the cases were asymptomatic, symptomatic cases with cough were 4% (3). On the basis of our data, 94.7% (71) of the cases were Antenatal, while Postnatal and Abortion were 4% (3) and 1.3% (1) respectively. Complications such as fetal distress 25.3% (19), scar tenderness 17.3% (13), pre-eclampsia 12% (9), post-dated pregnancy 9.3% (7), previous 2LSCS with...
Midwifery, 2021
Objective Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused many deaths and complications worldwide. However, limited data are available about COVID-19 during pregnancy. This study aimed to assess the epidemiological and clinical features of COVID-19, and the adverse maternal and fetal outcomes. Design This retrospective analytical cohort study was conducted on all pregnant women with confirmed COVID-19 at Nekouei-Hedayati-Forghani Hospital in Qom, Iran from 1 February 2019 to 15 September 2020. For the same period, 165 pregnant women who did not have COVID-19 were selected at random and included in this study. All epidemiological and clinical features were collected from the medical records of the participants. A logistic regression model was used to determine associations between COVID-19 in pregnancy and maternal and fetal outcomes. Findings The most common symptoms reported by pregnant women with COVID-19 were...
SSRN Electronic Journal, 2020
Background: Recent evidence suggests that pregnant women might be at higher risk of severe disease associated with the emerging pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while exposed fetuses/newborns could suffer from preterm birth, growth restriction and neonatal infections. The magnitude of this increased risk and specific risk factors for severity remains unclear. Methods: We performed a case control study comparing pregnant women with severe coronavirus disease 19 (case) to pregnant women with a milder form (controls) enrolled in COVI-Preg international registry cohort between from March 24 to July 26, 2020. Risk factors for severity, obstetrical, fetal and neonatal outcomes were assessed. Findings: A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented a severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of cesarean sections [70.7% (n=53/75)], preterm deliveries [62.7% (n= 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n=31/75)]. Interpretation: Pregnant women, particularly those with associated comorbidities, seem to be at higher risk of severe complications of SARS-CoV-2 infection. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease; complications include cesarean sections, prematurity and neonatal admission to the intensive care unit. Funding Statement: None. Declaration of Interests: The authors declare that they have no conflicts of interest. Ethics Approval Statement: The study was approved by both the Swiss Ethical Board (CER-VD- 2020-00548) and the local ethics boards at each participating center.
Impact of COVID-19 on Pregnancy Outcomes: A Cross Sectional Study
2021
Introduction: Atypical pneumonia known as coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, is highly infectious and is currently spreading rapidly around the globe. Objectives: The main objective of the study is to analyses the impact of COVID-19 on pregnancy outcomes among local population of Pakistan. Material and Methods: This cross sectional observational study was conducted in Lady Aitchison Hospital during September 2019 to August 2020. The data was collected through systematically designed questionnaire. Clinical characteristics, examination results, and treatment course were extracted from their medical records. For mothers, we collected socio demographic data, educational attainment, and occupation, maternal parity, medical history records, laboratory tests, and intensive care unit [ICU] admission. Results: The data was collected from 685 patients. The two groups of pregnant women were compared in terms of severe preeclampsia, gestational diabetes, p...
Study of Maternal and Fetal Outcome in COVID-19 Pregnancies
Background: Coronavirus has created a pandemic and extraordinary global Health crisis. Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus now called Severe acute respiratory syndrome coronavirus 2(SARS-COV-2).The virus can cause mild to severe respiratory diseases. The objective of this study is to summarize the Maternal and Fetal outcome in COVID-19 Pregnancies. Materials andMethods: We conducted an observational study over two months in the Department of Obstetrics, andGynaecology, at a COVID care Centre, Cama and Albless Hospital, Mumbai. The study enrolled a total of 192 COVID positive pregnant women with inclusion and exclusion criteria. We noted, Antepartum, Intrapartum and Neonatal parameters using preformed proforma. Results: In our study, we observed that most COVID positive pregnant women belonged to the age group of 25-29years.COVID-19 is more prevalent among primigravida(35%). Preeclampsia(37%) is more commonly associated with COVID patients. The Majority of pregnancies(74%) extended till Term. Vaginal Delivery(60%) was the most common mode of Delivery. 10% COVID positive pregnant women admitted tothe Intensive Care Unit. Maternal Mortality was 4% among COVID positive pregnancies. 13% of the babies tested COVID positive born to COVID positive mothers. NICU admission was required for 38% of the positive babies. Only one neonatal death occurred among COVID positive babies. Conclusion: Per se pregnancy and childbirth do not increase the risk of acquiring SARS-COV-2 infection, however pregnancy with high risk factors like age >35years, pre-eclampsia, preexisting lung pathology, diabetes, obesity increases the inflammatory response (cytokine storm) and may worsen the clinical course of COVID-19
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: A three wave pattern of corona virus has been seen in many countries during the 2020 pandemic. Observed data show that the effects of the virus do vary between the three waves. Differences in severity of the disease have been reported, although the comparative characteristics of the three waves still remain largely unknown.Methods: This was a prospective cross sectional study continuation of our first paper comparing 133 pregnant COVID- 19 positive patients in the first wave and 251 patients admitted during second wave and 92 patients in third wave who delivered at district hospital, Bellary.Results: In the present study 72.8% patients were in the age of 20-30 years, 85.87% patients belong to lower socio- economic status, mild anaemia about 32.6% in third wave, moderate anaemia seen in 10.8% in third wave, and 3.44% had severe anaemia. Non-severe pre-eclampsia was present in 10.8% of the patients, severe pre-eclampsia was seen in 6.52% of the cases and. Mode of delivery ...
Saudi Medical Journal
Objectives: To investigate the association between the hospitalization rates, symptoms, and laboratory parameters of pregnant women diagnosed with coronavirus disease 2019 (COVID-19) and the gestational week, and determine their symptoms or laboratory parameters predictive of the need for possible admission in the intensive care unit (ICU). Methods: We retrospectively analyzed the symptoms, laboratory parameters, and treatment modalities of 175 pregnant women with COVID-19 who were admitted to a tertiary referral hospital between March 2020 and March 2021 and investigated their association with pregnancy trimesters. Original Article Results: The COVID-19-related hospitalization rates in the first trimester was 24.1%, second trimesters was 36%, and third trimester was 57.3%. Cough and shortness of breath were significantly higher in the pregnant women in their third trimester than those in the first 2 trimesters (p=0.042 and p=0.026, respectively). No significant relationship was found between pregnancy trimesters and the need for ICU admission. Shortness of breath at the first admission increased the need for ICU by 6.95 times, and a 1 unit increase in C-reactive protein (CRP) level increased the risk of ICU by 1.003 times. Conclusion: The presence of respiratory symptoms and the need for hospitalization increased significantly with later trimesters in pregnant women with COVID-19. The presence of shortness of breath or high CRP level at the time of admission could predict the need for ICU admission.