One-pot multicomponent synthesis of polyhydroquinolines under catalyst and solvent-free conditions (original) (raw)

Green Chemistry Letters and Reviews, 2012

Abstract

An efficient one-pot condensation has been developed for the synthesis of polyhydroquinolines via a four component coupling reaction of aldehyde, dimedone, ethyl acetoacetate, and ammonium acetate under catalyst and solvent-free conditions. Non-hazardous experiment procedure, operational simplicity, mild reaction conditions, and the compatibility with various functional groups represent the advantages of the present method.

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