Relation between maternal lipid profile and pregnancy complications and perinatal outcomes (original) (raw)

2021, Al-Azhar International Medical Journal

Background: Pregnant experiences physiological changes in maternal lipid metabolism to support fetal growth and development. In some cases a maladaptation occurs and exceeds the physiological range and dyslipidemia is recognized, some pregnancies pacing without associated pregnancy alterations and in pregnancies pacing with pathologies. Aim of the study: determine the relationship between maternal lipid profile and pregnancy and perinatal complications. Besides, determine the cut-of value of each lipid profile components for predicting maternal compilations. Patient and Methods: 164 pregnant who attended the Obstetrics and Gynecology department in Suez Canal Authority Hospital in Ismailia city, throughout the period May 2018-October 2019. Pregnant were assessed clinically, obstetrically, and tested for lipid profile during 2nd and 3rd Trimester, for detecting any maternal or neonatal complications. Results: 28 pregnant developed maternal complications [GΗTN (3.66%), Preeclampsia (2.44%), GDM (3.05%), IΗCP (1.83%), РTL (4.27%), PTB (3.05%) and ROM (4.78 %)]. Lipid profile in complicated cases during 2nd/3rd trimester for TC, TG, LDL, and ΗDL were 189.3 ± 4.8/243.2 ± 4.8 mg/dl, 271.0 ± 8.4/251.2 ± 8. 4 mg/dl, 110. 8 ± 5.6/114.2 ± 5.6 mg/dl) and 60.4 ± 1.8/61.2 ± 1.9 mg/dl). We observed every mg/dl elevation in maternal 3rd-trimester TG concentration was associated with an increased risk of GDM, GΗTN, preeclampsia, and IΗCP. Every mg/dl increase in 3rd-trimester TG concentration was associated with an increased risk for SGΑ, LGΑ, and macrosomia. Conclusion: maternal dyslipidemia is a risk factor and associated with the development and occurrence of maternal complications during pregnancy and affects neonatal outcomes.