Microfabricated Porous Membrane Structure for Sample Concentration and Electrophoretic Analysis (original) (raw)

Abstract

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The study presents a novel microfabricated injection valve equipped with a porous membrane structure designed for the electrokinetic concentration of DNA samples. This device enhances both concentration and subsequent electrophoretic analysis of DNA fragments by utilizing a thin porous silicate layer that allows current passage while restricting large DNA molecules. Experimental results demonstrate the capability of concentrating DNA up to two orders of magnitude, highlighting the effectiveness of the system for high-throughput applications in biochemical analysis.

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