Antifouling and Quorum Sensing Inhibitory Potential of Brazilian Marine Sponges (original) (raw)

2015

Abstract

Marine sponges are rich sources of biologically active compounds which can be used in biotechnological applications. Quorum sensing (QS) is a bacterial population density dependent genetic mechanism regulating adhesion, growth, and biofilm formation. Thus, compounds that inhibit QS provide a way to control biofilm and biofouling. In this study, we screened extracts of 14 marine sponges from upwelling and non upwelling areas for their ability to inhibit bacterial QS, biofilm formation, growth and larval settlement of Bugula neritina . About 85% of MeOH (methanol:water) and 7% of DCM (dichloromethane) extract showed QS inhibitory properties for Chromobacterium violaceum CV017. Quantitative determination of QS based on production of violacein by C. violaceum CV017 and elastase by Pseudomonas aerugionosa PA01 demonstrated that the same species of sponges collected from upwelling and non upwelling area had different activity. Both extracts of A. brasiliensis (DCM and MeOH) as MeOH of Pac...

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