Hematologic Toxicities and its Determinants among Breast Cancer Patients Treated with Doxorubicin-Cyclophosphamide Followed by Paclitaxel Regimen in Cancer Centers: Retrospective Cohort Study (original) (raw)

Abstract

Background Clinically, chemotherapy induced neutropenia, febrile neutropenia, thrombocytopenia and anemia were the common toxicities among breast cancer patients treated with doxorubicin-cyclophosphamide followed by paclitaxel regimen. Those toxicities may lead to chemotherapy dose modification, delay and discontinuation that may substantially compromise therapeutic outcomes. Objective To assess hematologic toxicities and its determinants among breast cancer patients treated with doxorubicin-cyclophosphamide followed by paclitaxel regimen in cancer centers, Northwest Ethiopia. Method Retrospective cohort study design was used to collect data among 422 breast cancer patients from Felege-Hiwot Comprehesnsive and Specialized Hospital and University Of Gondar Comprehensive and Specialized Hospital using a structured data abstraction format by employing systematic random sampling technique. The collected data were entered into EPI-data version 3.1 and analysed using IBM SPSS version 26. ...

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