Evaluation of cytotoxicity of leaf and rhizome extracts of Alpinia calcarata rosc. against human lung nci-h460 and cervical hela cancer cell lines (original) (raw)

2017, Sri Lankan Journal of Biology

The cytotoxicty of Alpinia calcarata rhizome and leaf extracts, fractions and essential oils were evaluated in vitro against human lung NCI-H460 and cervical HeLa cancer cell lines using sulphorhodamine-B assay. Although an array of bioactivities of A. calcarata rhizome have been reported previously, no attempt has been made to study the cytotoxicity of rhizome in human lung NCI-H460 and cervical HeLa cancer cell lines. In the present study, both the leaf and rhizome extracts (ethanolic and water) along with their fractions (hexane, dichloromethane, ethylacetate, butanol and water) and essential oils against human lung (NCI-H460) and human cervical (HeLa) cancer cell lines were investigated. Fresh rhizomes and leaves of Alpinia calcarata, collected from Western Province of Sri Lanka were used to obtain the extracts. The essential oils were obtained by hydro-distillation. All the samples were stored at 4 °C. The extracts, fractions and essential oils demonstrated a varying degree of ...

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