Review Article mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions (original) (raw)

2016

Abstract

Copyright © 2014 Mehvish Showkat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. mTOR is a central nutrient sensor that signals a cell to grow and proliferate.Through distinct protein complexes it regulates different levels of available cellular energy substrates required for cell growth. One of the important functions of the complex is to maintain available amino acid pool by regulating protein translation. Dysregulation of mTOR pathway leads to aberrant protein translation which manifests into various pathological states. Our review focuses on the role mTOR signaling plays in protein translation and its physiological role. It also throws some light on available data that show translation dysregulation as a cause of pathological complexities like cancer and the available drugs that target the pathway for cancer...

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