Histopathological study of nasal lesions: 2 years study (original) (raw)

Histopathological Spectrum of Nasal Diseases-A Study of 100 cases

IOSR Journals , 2019

Nose and paranasal sinuses are aptly called air conditioner for lung.Various authors have studied lesions of nose and paranasal sinuses in different aspects.The present study includes 100 cases of nasal cavity and paranasal sinuses presented to Department of Pathology, Government medical college, Patiala from December 2010 to October 2012. In this study of 100 cases, 81 were non-neoplastic and 19 were neoplastic lesions forming a ratio of non-neoplastic to neoplastic lesions as 4.2: I and the ratio of benign neoplastic and malignant lesions as 2.1:1. The incidence of nasal polyps in our study is 81% of all the non-neoplastic lesions of nasal cavity and PNS thus forming the commonest nasal lesion in this study. Allergic polyps were much more common than inflammatory polyps. In the present study, there were 8 males and 3 females forming a ratio of 2.7:1. Out of all neoplastic lesions, inverted papilloma (11 out of 19 cases) was the most frequent, representing 57.90%. Of the 6 malignant tumours, SCC (5 out of 19 cases) was the commonest. One case of sino-nasal adenocarcinoma was diagnosed during the study period. Thus the adenocarcinomas were found to be rare. Thus categorizing the sino-nasal lesions according to histopathological features into various types helps us to know the clinical presentation, treatment, clinical outcome and prognosis of the disease.

Histomorphological Study of Benign Nasal Masses – a Five Year Study

2018

Non-neoplastic and neoplastic lesions of nasal cavity, paranasal sinuses and nasopharynx presents as either polypoidal mass or irregular mass. The lesions affects up to 4% of the population, commonly seen in middle aged males. 1,2 Nasal polyps are the projections of mucous membrane covered by columnar to ciliated epithelium and extends into the nasal Address of Correspondence: Dr Shashikala P Professor & Head, Department of Pathology S. S. Institute of Medical Sciences & Research Centre, Davangere Email:shashikalakrishnamurthy16@gmail.com cavity, paranasal sinuses or nasopharynx. 3

ROLE OF HISTOPATHOLOGY IN THE DIAGNOSIS OF NASAL POLYPOIDAL MASSES

Nasal polyps were first described more than 2500 years ago and comprise the most common group of mass lesion encountered in the nose. The word polyp comes from Greek although it was subsequently latinized and means many footed (polypous). Oedematous, hypertrophied and sagged masses of nasal mucous membrane covered with columnar and ciliated epithelium are called nasal polyp. They may be solitary or multiple, pedunculate or sessile, unilateral or bilateral. Polyps were recognized as projection of mucous membrane developing in association with chronic rhinitis, sinusitis, but more especially with allergic disease and polypoid benign and malignant neoplasm. For the reason it becomes important that all polyps and polypoidal lesions of nose should be submitted for histopathological examinations. Therefore, types of polyps, their histomorphology, etiopathogenesis, and the contribution of allergy, bacterial infection and other causes of formation of polyps will need to be evaluated.

Polypoidal Lesions in the Nasal Cavity

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013

Introduction: Nasal polyps are polypoidal masses arising from mucous membranes of nose and paranasal sinuses. They are overgrowths of the mucosa that frequently accompany allergic rhinitis. They are freely movable and nontender. Aims and Objectives: The purpose of this study was to study the histopathologic spectrum of polypoidal lesions of the nasal cavity. Materials and Methods: The study comprised of 100 consecu tive cases of polypoidal lesions in the nasal cavity, received in the department of pathology. The age and sex of the pati ents were recorded. The tissues were routinely processed for histopathologic sections and stained with haematoxylin and eosin stains. Special stains like Periodic acid Schiff (PAS) was done wherever applicable. The cases were classified into neoplastic and nonneoplastic lesions. The neoplastic lesions were further classified according to WHO classification on histopathologic examination. Results: Analysis of 100 polypoidal lesions in the nose and paranasal sinuses with clinical diagnosis of nasal polyps, revealed 66 cases were nonneoplastic and 34 were neoplastic;17 (50%) were benign and 17(50%) were malignant. True nasal polyps both inflammatory and allergic together comprised 44 cases of the 100 polypoidal lesions in the nasal cavity. Angiofibroma and inverted papilloma were the most frequent benign tumour accounting for 12/17(0.7%). The most common malignant tumour was anaplastic carcinoma 7/17(0.4%). Nonneoplastic and benign tumours were common in younger age groups whereas malignant tumours were most common in older males. Conclusion: The majority of polypoidal lesions in the nasal cavity are nonneoplastic.

Clinico-pathological Profile and Management of Sino-nasal Masses: A Prospective Study

Indian Journal of Otolaryngology and Head & Neck Surgery, 2012

The work was planned to study-the demographic profile of sino-nasal masses, the clinical and radiological findings of sino-nasal masses and the correlation of the clinical and radiological findings with the histopathology. The study was conducted on the patients having sino-nasal masses admitted in Department of ENT, SMS Hospital, Jaipur from August 2008 to July 2010. The study was designed to evaluate the demographic distribution, clinicopathological features, radiological finding of sino-nasal masses and to evaluate the correlation of clinical and radiological findings with the histopathological diagnosis. Comparison of clinical and radiological findings in our study showed that in 83.07 % patients the radiological findings were consistent with that of clinical suspicion. In rest either the radiological findings were different or inconclusive. It is concluded that for proper evaluation of nasal polyps clinical, radiological and histopathological evaluation should be done in all the patients, where radiology provides a road map to the endoscopic surgeons and warns of any existing or impending complications. Histopathology always gives a confirmatory diagnosis.

Spectrum of neoplastic sino-nasal lesions at tertiary care centre

IP innovative publication pvt ltd, 2020

Introduction: The nasal cavity, paranasal sinuses and nasopharynx form a functional unit of the nose and its anatomical location makes it the fertile land for exposure to several pathogenic factors Nasal symptoms are one of the commonest reasons for which patient seeks medical advice and as the nose occupies prominent anatomical position on the face, early diagnosis and treatment of any scarring or ulcerative lesion is imperative. Clinically and radiologically benign and malignant lesions are difficult to differentiate. So, histopathology remains main diagnostic approach for the lesions of sino-nasal tract. In present study attempt is made to study histopathological spectrum of sino-nasal lesions with regard to age and sex distribution. Materials and Methods: All indoor and outdoor patients attending ENT department with complains of nasal mass, obstruction, discharge, bleeding and others were selected for this study during tenure of 2014- 2018. All the tissues were fixed in 10% formalin, processed, stained with H and E and studied for various histopathological features. Results: In present study, out of total sinonasal lesions, non-neoplastic lesions were highest(60%) followed by benign (24.62%) and malignant lesions (15.38%) respectively. Malignant lesions were found in fifth, sixth and seventh decade mainly. All sino-nasal lesions presented with common symptom of nasal obstruction without discrimination of non-neoplastic and neoplastic lesions. Males showed maximum (70.76%) lesions of all categories. Conclusion: Majority of sinonasal lesions present with complain of obstruction, out of which majority were non-neoplastic lesions, hence histopathological examination remains main stay to differentiate nonneoplastic, benign and malignant lesions to avoid un-necessary surgery.

Presentation of Lesions of Nose and Paranasal Sinuses at a Tertiary Care Center in Central India

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2018

A variety of non-neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinus and are fairly common presentation encountered in clinical practice. Sinonasal lesions are a common finding in all age groups. The lesion of nose and paranasal sinuses are very deceptive so, the presenting features, clinical examination, nasal endoscopy, radiodiagnosis and histopathology are employed conjointly to reach a diagnosis. This cross sectional study was conducted between November 2014 and September 2016. 150 patients with nasal or paranasal sinus lesions attending ENT OPD were included. Among 150 patients there was a male predominance in all lesion except malignant lesions and most of the patients 72 (48%) were in the age group 11- 30 years. Mean age of presentation for benign lesions was 33.64 years and of malignant lesions was 49.14 years. The study showed that 96 (64%) of the nose and PNS lesions were of inflammatory nature followed by 22 (15%) benign, 18 (12%) granulomatous ...

Histomorphological Study of Polypoidal Lesions of the Nose and Paranasal sinuses

The Internet Journal of Pathology, 2011

Introduction: A variety of non-neoplastic and neoplastic conditions present as polypoidal lesions of nasal cavity and paranasal sinuses. These are very common lesions encountered in clinical practise. The aim was to study the histopathological patterns of polypoidal lesions of nose and paranasal sinuses. Methods: A retro prospective study was carried out at the department of Pathology in a tertiary care centre for a period of five years from 2010 to 2014. The tissues were routinely processed for histopathology and stained with haematoxylin and eosin stain. Special stains were used wherever required. Observations and results: A total of 132 cases presented as polypoidal lesions of nose and paranasal sinuses. Non neoplastic lesions constituted about 76% of cases with inflammatory polyp being the commonest type seen in 55.3% of cases followed by allergic polyp (6.8%), rhinoscleroma(8.3%), rhinosporidiasis(0.7%), lepromatous leprosy(2.2%), granulation tissue(3%) and rhinolith(0.7%). Neoplastic lesions constituted 24% of cases with 16% benign tumors and 8% malignant tumors. Capillary hemangioma was the predominant benign tumor seen in 6% of cases .The most common malignant tumour was squamous cell carcinoma (2.2%) Conclusion: Non neoplastic lesions are common compared to neoplastic lesions and inflammatory polyps are the predominant polypoidal lesions.

Clinico-pathological and radiological assessment of benign nasal masses

International Journal of Otorhinolaryngology and Head and Neck Surgery

A variety of neoplastic, non-neoplastic and inflammatory conditions involve the sinonasal cavity and these are encountered in day to day clinical practice. Incidence of these lesions is often stated to be between 1% and 4% of the population. 1 Sinonasal masses can be divided into two main categories: non neoplastic and neoplastic, which in turn are further divided into benign and malignant. Benign neoplasia of the nose and paranasal sinuses is relatively not uncommon. The benign nasal masses include nasal polypi, inverted papillomas, osteomas, haemangiomas, angiofibromas, meningocoel and meningoencephalocoele. The prevalence rate of nasal polyposis is about 2%. 2 Antrochoanal polyp is the most common choanal polyp arising from one of the paranasal sinuses. 3 Various pathologal events ranging from nonneoplastic to malignant sinonasal tumors may mimic a simple mass. Common causes of nasal obstruction are inflammatory polyps, with a prevalence of 4% in general population. 4 Benign tumors are relatively common, but malignant neoplasms are rare, relaying to 0.2-0.8% of all ABSTRACT Background: Sinonasal masses are uni or bilateral with variable and with multiple etiological factors. Benign masses are common in comparison to malignant in this region. Some of the benign masses e.g. juvenile angiofibroma and inverted papilloma cause local bony destruction. Preoperative radiological assessment is desirable for proper surgical Management. The purpose of the study was to assess the clinical and radiological findings of sinonasal masses and the correlation of the clinical and radiological findings with the histopathology. Methods: This prospective study was carried out on 50 cases if intra nasal masses. After clinical examination, these patients were subjected to radiology. The parameters assessed were the origin, extension, involvement of adjacent structure. Subsequently, all the cases were subjected to surgery i.e. polypectomy, medial maxillectomy, excision with the help of nasal endoscope. Thereafter, the histopathological findings were correlated with clinical and radiological findings. Results: Total 50 cases of intra nasal benign masses were included in the study. Among them 36 (72%) cases were of nasal polyps, out of which 29 (80.5%) were inflammatory polyps and 7 (19.4%) were allergic polyps. Among inflammatory polyps, 23 (79.3%) were males and 6 (20.69%) were females. Among allergic polyps 4 (57.14%) were males and 3 (42.85%) were females. The other findings were 5 (10%) cases of angiofibroma, 5 (10%) cases on inverted papilloma, 3 (6%) cases of haemangioma and 1 (2%) cases of chondrosarcoma. Conclusions: Considering the result obtained, the most common sinonasal lesions were inflammatory polyps. Others in order in order of frequency were allergic polyp, angiofibroma, inverted papilloma, haemangioma and chondrosarcoma.