The Use Of Sea Cucumber Paracaudina australis Extract To Improve Glucose Tolerance In Diabetes Mellitus (original) (raw)
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Folia Medica Indonesiana, 2019
Diabetes mellitus (DM) is one of disease that its incidence increases every year worldwide. The condition of DM can cause various complications caused by oxidative stress. Stichopus hermanii (SH) or golden sea cucumber extract contains antioxidant compounds that have been proven to reduce oxidative stress conditions. The purpose of this study was to investigate the effect of Stichopus hermanii extract on condition of diabetes mellitus by looking at changes in fasting blood glucose, plasma insulin, and malondialdehyde levels in animal models of Wistar rats. This study was a laboratory experimental study using Randomized Control Trial Design with Post-test only control group design. Thirty-five male Wistar rats divided into five groups, i.e normal control group, positive control, negative control and two treatment groups with SH extract dose 8.5 and 17 mg / kgBW for 14 days once daily after induction of Streptozotocin at the Biochemistry Laboratory of the Faculty of Medicine, Airlangg...
Iranian journal of basic medical sciences, 2011
Seed of Cucumis sativus Linn. is one of the herbal remedies has been traditionally used for diabetes mellitus treatment. We studied the effect of hydroalcoholic and buthanolic extract obtained from C. sativus seeds in a model of streptozotocin (STZ)-induced diabetic (type I) rats. Normal and diabetic male Wistar rats (STZ, 60 mg/kg, intraperitoneal) were treated daily with vehicle (5 ml/kg), hydroalcoholic (0.2, 0.4, 0.8 g/kg) and buthanolic extract (0.2, 0.4, 0.8 g/kg) and glibenclamide (1 & 3 mg/kg) separately and treatment was continued for 9 days. Blood samples were taken at 0, 1, 2, 3, 4, 8 hr of the first day and the day 9 (216 hr) of treatments for measuring the blood glucose levels. Our findings indicated that C. sativus seeds extracts were not effective on reducing blood glucose levels (BGL) in normal and diabetic rats for initial phase of treatments. However, both hydroalcoholic (22.5-33.8 %) and buthanolic (26.6- 45.0 %) extracts were effective on diminishing BGL and cont...
Indonesian Journal of Medical Sciences and Public Health
Diabetes mellitus is a metabolic disease characterized by conditions of hyperglycemia as a result of abnormalities in the secretion of the insulin hormone, the work of the insulin hormone, or both. Metabolic disorders caused by diabetes cause lipolysis to increase, thereby increasing the level of VLDL, which will be converted to LDL. LDL disorders are the effects of insulin resistance. Streptozotocin (STZ) can increase serum LDL cholesterol serum levels due to the mechanism of ROS formation. Golden sea cucumber act as anti-hyperlipidemic because they contain EPA-DHA, saponins, and flavonoids. The purpose of these studies to determine the effect of Golden sea cucumber act as anti-hyperlipidemic. Experimental laboratory research is done using the post-test only control group design method. Using simple random sampling with 25 white male Wistar rats divided into five groups, all rats were given standard feeding. Group 1 without STZ induced, group 2-5 were induced STZ first, and then gr...
Journal of Young Pharmacists, 2010
The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxaninduced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood glucose concentration of normoglycemic rats treated with oral doses of 1000 and 1500 mg/kg of the extract. On the other hand, 500 mg/kg of the fruit extract produced an insignificant (P > 0.05) decrease in blood glucose levels of alloxan-treated rats, while 1000 and 1500 mg/kg oral dose points produced a significant (P < 0.05) decrease in the blood glucose concentration of hyperglycemic rats comparable to that produced by tolbutamide. From this study, the data suggested that the fruit extract did not alter the BGC level in normoglycemic rats, but had a potential hypoglycemic property in alloxan-induced hyperglycemic rats.
Studies have proven the antidiabetic property of fruit, seeds and pulp of Cucumis sativus. Hence, to investigate the antidiabetic property of the leaf, the aqueous leaf extract of Cucumis sativus L. (Cucurbitaceae) was investigated on alloxan induced type 2 diabetic rats. Diabetes mellitus was induced with alloxan and different graded doses of the extracts were then administered to normal and experimental diabetic rats for 12 days. Evaluation was done in normal rats for fasting serum lipid profiles, plasma glucose levels, and changes in body weight while in diabetic rats, additionally liver glycogen levels and pancreatic TBARS levels were evaluated. Standard glibenclamide were then used for comparing all the diabetic groups. The results of our study support the claim of antidiabetic property of Curcumis sativus.
Bioscience, Biotechnology, and Biochemistry, 2016
Postprandial blood glucose control is the major goal in the treatment of diabetes. Here, we investigated the effect of sea cucumber saponins (SCSs) on postprandial blood glucose levels. SCS inhibited yeast as well as rat intestinal α-glucosidase activity in a dose-dependent manner and showed better inhibition of yeast α-glucosidases compared to the positive control. Further studies were performed using ICR mice treated with SCS and starch or SCS alone by oral gavage. Unexpectedly, SCS increased postprandial blood glucose levels a short time (1 h) after oral gavage. The serum corticosterone (CORT) level showed a consistent correlation with glucose levels. In vitro experiments confirmed that SCS treatment increased the secretion of CORT in the Y1 adrenal cell line. Overall, these studies demonstrated that SCS gavage could inhibit α-glucosidase activity but cannot attenuate postprandial blood glucose level within short time periods. The underlying mechanisms are probably related to inc...
Antidiabetic Principle in Cucumis sativus L
IntechOpen, 2021
Diabetes is one of the leading cause of death globally. One of the strategies towards managing diabetes is the antidiabetic drugs which has recorded a huge success but accompanied with different degrees of side effect, hence, the use of natural plants products is encouraged. Several reports of antidiabetic medicinal plants have flooded literature but few has led to identification of active ingredient in such. Cucumis sativus is one of such plants reported to have antidiabetic property but there is little or no data on the active agent. This chapter therefore provides report on the active principle and mechanism of action underlying the antidiabetic activity of C. sativus.
Veterinary World, 2019
Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.
Asian Journal of Biochemistry, Genetics and Molecular Biology
The effect of Protein isolate from fermented melon seeds (Ogiri Protei Isolates; OPI) of Cucumeropsis manii on blood glucose, lipid profile, and antioxidant enzyme activities in streptozotocin (STZ)-induced diabetic rats was investigated. Thirty Male Wistar rats were divided into five equal groups. GThe first control group with no exposure. The second group of rats with Streptozotocin-induced non-treated diabetes. The 3rd and 4th groups of rats with Streptozotocin-induced diabetes supplemented with Ogiri protein isolates (200, 600 mg/kg in diet). And the 5th group of rats with Streptozotocin-induced diabetes administered glibenclamide in a dose 500 ug/kg in diet [17]. The OPI was administered for 6 weeks. The administration of OPI reduced the blood glucose concentration of the STZ-induced diabetic rats. Sera and hepatic superoxide dismutase, activities of the STZ-induced diabetic rats were significantly (P< 0.05) increased in comparison with the diabetic control rats. Lipid perox...
Journal of Medicinal Plants Research, 2014
Phytochemical screening and hypoglycemic effect of methanolic fruit pulp extract of Cucumis sativus on alloxan induced diabetic rats was investigated. The phytochemical analysis of the methanolic fruit pulp extract of C. sativus indicated the presence of saponins, glycosides, terpenes, phenolics, alkaloids, flavonoids, and tannins. The methanolic fruit pulp extract of C. sativus was administered orally to the alloxan induced diabetic rats and it significantly decreased (P<0.05) the fasting blood glucose concentration (mg/dl) from 231.25±1.11 to 82.25±1.55 at 500 mg/kg body weight. The standard antidiabetic drug (Glibenclamide) administered orally at 5 mg/kg body weight also significantly decreased (P<0.05) blood glucose concentration from 189.00±2.42 to 61.00±2.48. This study therefore revealed that the methanolic fruit pulp extract of C. sativus contains active substances with hypoglycemic activity and could be used in the treatment and management of diabetes mellitus.