The performance of various laboratory parameters to differentiate follicular thyroid carcinoma and follicular thyroid adenoma (original) (raw)
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Al Mustansiriyah Journal of Pharmaceutical Sciences, 2018
The main problem encountered in thyroid nodule is difficult to differentiate between a benign and malignant lesion. Differential between follicular thyroid cancer (FTC) and benign follicular thyroid adenoma (FTA) is a great challenge for even an experienced pathologist and requires special effort. A total of 120 paraffin block were included in the study, 30 blocks were (FC), 30 blocks were (FVPC). 30 blocks were (FA), 30 blocks were blocks thyroid follicular hyperplasia.20 blocks endocervical epithelium.20 paraffin blocks of colonic epithelium as control. From each paraffin block, 4 slides, each of thicken were taken, stained with Hematoxylin and Eosin (H&E) for revision of histopathological diagnosis. The histological arrangement in follicular carcinoma and follicular adenoma was significant (P= 0.001) in trabecular pattern and the difference was significant (P= 0.016) in mixed pattern while no significance with microfollicular, macrofollicular and normofollicular pattern in both f...
IP Innovative Publication Pvt. Ltd., 2017
Introduction and Objective: Thyroid gland lesions are seen worldwide with geographical variation in incidence and histopathological pattern related to age, sex, dietary and environmental factors. This study is aimed to describe the histomorphological spectrum of thyroid lesion in relation to age, sex distribution and also to compare the findings with other studies done in India and elsewhere. Materials and Method: It is a prospective study of all thyroidectomy specimens received from June 2015-Dec 2016 in department of pathology, Dr. B R Ambedkar Medical College, Bengaluru. Results: A total of 100 cases were studied. Female to male ratio was 6:1. The age group ranged from 12-75yrs with peak incidence seen at 35-45yrs. The lesions were classified as non-neoplastic and neoplastic. Non-Neoplastic lesions were more common and accounted for 82% and neoplastic lesions accounted for 18%. The most common lesion was goiter (68%), followed by thyroid adenomas (16%) and thyroid carcinomas (2%). There were 7 cases of toxic goitre (7%), 4 cases of thyroglossal cyst (4%) and 3 cases of thyroiditis (3%). Conclusion: The study shows that thyroid gland diseases are seen in both genders with female preponderance. Among the varied histomorphological spectrum of surgical lesions of thyroid, colloid goiter is the most common lesion. Follicular adenoma is the commonest benign tumor and a higher incidence of follicular carcinoma was seen.
Analysis of malignancy predictors for follicular thyroid tumors
Vojnosanitetski pregled, 2020
Background/Aim. Establishing a preoperative diagnosis of thyroid follicular tumors is difficult due to the fact that the cell morphology of adenomas and carcinomas are similar and that capsular and vascular invasion cannot be determined by cytology. We analyzed predictive factors of follicular carcinoma in order to enable a surgeon to indicate operative treatment and to perform an adequate operation for each patient with a follicular neoplasm. Methods. In this retrospective study, we analyzed medical records of all patients with follicular thyroid tumors operated at an endocrine surgery unit of a tertiary referral academic hospital, between 2008 and 2012. A total of 263 operated patients were included and divided into follicular adenomas (n = 97) and follicular carcinomas (n = 166) based on the histopathology results. The most important demographic and clinical characteristics were analyzed by univariate and multivariate logistic regression analysis. Results. In adenoma group (19 ma...
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience
The Scientific World Journal, 2014
Follicular thyroid carcinoma classically accounts for 10-32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2012 for thyroid malignancies were reviewed. Those who had a histological diagnosis of follicular carcinoma were included. Among 5203 patients, 130 (2.5%) were included. Distant metastases at presentation were observed in four patients. Sixty-six patients had a minimally invasive follicular carcinoma and 64 a widely invasive follicular carcinoma. In 63 patients an oxyphilic variant was registered. Minimally/widely invasive ratio was 41/26 for usual follicular carcinoma and 25/38 for oxyphilic variant ( < 0.05). Patients with widely invasive tumors had larger tumors ( < 0.001) and more frequently oxyphilic variant ( < 0.05) than those with minimally invasive tumours. No significant difference was found between widely invasive and minimally invasive tumors and between usual follicular carcinoma and oxyphilic variant regarding the recurrence rate ( = NS). The incidence of follicular thyroid carcinoma is much lower than classically retained. Aggressive treatment, including total thyroidectomy and radioiodine ablation, should be proposed to all patients.
Saudi medical journal, 2012
To determine the rates of malignancy of thyroid nodules in each standard cytologic diagnostic category of the Bethesda system. In a retrospective cohort study from October 1998 to April 2007 at the Department of Pathology, Aseer Central Hospital, Southwestern region of Saudi Arabia, all cases of thyroid nodules that underwent preoperative cytologic examination by fine-needle aspiration (FNA) and concurrent postoperative histopathologic examination were included. All FNA diagnoses were reclassified using the thyroid FNA Bethesda reporting system, including non-diagnostic (insufficient), benign, atypical follicular lesion of undetermined significance (AFLUS), neoplasm, suspicious of malignancy, and malignant groups. The rate of malignancy based on final histopathologic evaluation was analyzed for each of these cytologic groups. A total of 323 thyroid fine needle aspiration cytology (FNAC) diagnoses were reclassified into non-diagnostic 6.2%, benign 57.3%, AFLUS 13.6%, follicular and H...
Cytohistologic Correlation Study of Thyroid Lesions with Emphasis on the Diagnostic Pitfalls
Journal of King Abdulaziz University-medical Sciences, 2011
Fine needle aspiration of thyroid is proven to be the most economical and reliable diagnostic tool for distinguishing neoplastic from non-neoplastic nodules for better selection of patients for surgery. The aim of this study is to evaluate the diagnostic accuracy of thyroid cytology performed at our institution by correlating its results with final histopathological diagnosis. This retrospective study used two-hundred and seventy-one cases of thyroid cytology performed at King Abdulaziz University Hospital between 1995 and 2007. The corresponding histopathological slides were reviewed. The sensitivity and specificity of cytology for detecting neoplasia at our institute were calculated at 71% and 93%, respectively. The most common benign lesion diagnosed was multinodular goiter (46%), and the most common malignancy was Papillary Thyroid Carcinoma (16%). The major cause of false positive diagnosis is the overlapping cytological features in hyperplasia that can be misinterpreted as features of neoplasia; whereas the main reason of false negative diagnosis is failure to recognize the follicular variant of papillary thyroid carcinoma. The study confirmed the efficiency of cytology in the evaluation of both nodular and diffuse thyroid lesions. However; cytopathologists should be aware of the potential diagnostic pitfalls in order to achieve a higher rate of diagnostic accuracy.
Prevalence of malignancy in thyroid nodule at People’s Medical College Hospital (PMCH) Nawabshah
The Professional Medical Journal
Objectives: The purpose of study is to ascertain the prevalence of malignancy in thyroid single/multiple nodules after ascertaining the features of nodules on different criteria. Study Design: Cross Sectional Study. Setting: Department of Surgical at PMCH Nawabshah. Period: April 2015 to April 2018. Material & Methods: All patients got admission from OPD and they were investigated for the disease. All biochemical examinations were done. Thyroid profile with thyroid scan was obtained. Fine Needle Aspiration Cytology (FNAC) was done to diagnose the type of cells either benign/ malignant. The decision of the surgical procedure was done according to the FNAC report of the thyroid nodule. Results: Total 80 patients were investigated. 55 (68.75%) females, 35 (43.75%) male and 60 (75%) showed the benign cells and 20 (25%) patient’s reports had malignant cells. Biopsies were sent for histopathology. 60 (75%) showed thyroid adenomas after biopsy. 10(12.5%) patients papillary carcinoma, 7 (8....
2011
Objective: The study was conducted to determine the frequency and clinicopathological aspects of various types of thyroid cancers in patients presenting with goitres and thyroid nodules. Study Design: Descriptive cross sectional study. Place and Duration of Study: It was an 11 year ret-rospective study commencing from January 2000 to December 2010 conducted at the Department of Patho-logy, King Edward Medical University, Lahore, Pakis-tan. Materials and Methods: Clinical data and Histopa-thology Reports of 2785 thyroid surgical specimens referred from the Surgical Units of Mayo Hospital, La-hore were reviewed and malignant cases were retri-eved for inclusion in this study. Patients from both sexes and all age groups were included. Results: Reports of a total of 2785 thyroid specimens were reviewed, out of which 170 cases (6.10%) were found to be thyroid cancers. These comprised of 130 cancers (76.47%) in females and 40 cases (23.52%) in males giving a female to male ratio ...
Diagnostic Pathology, 2010
Background: Thyroid nodules are common among adults though only a small percentage is malignant, which can histologically mimic benign nodules. Accurate diagnosis of these thyroid nodules is critical for the proper clinical management. Methods: We investigated immunoexpression in 98 surgically removed benign thyroid nodules including 52 hyperplastic nodules (HN) and 46 follicular/Hurthle cell adenomas (FA), and 54 malignant tumors including 22 follicular carcinoma (FC), 20 classic papillary carcinoma (PTC), and 12 follicular variant papillary carcinoma (FVPC). Results: The staining results showed that malignant tumors express galectin-3, HBME-1, CK19 and Ret oncoprotein significantly more than benign nodules. The sensitivity of these markers for the distinction between benign and malignant lesions ranged from 83.3% to 87%. The sensitivity of two-marker panels was not significantly different. Immunoexpression was usually diffuse and strong in malignant tumors, and focal and weak in the benign lesions. Conclusion: Our findings indicate that these immunomarkers are significantly more expressed in malignant tumors compared to benign lesions and may be of additional diagnostic value when combined with routine histology.
Collegium antropologicum, 2010
Our aim was to assess malignancy risk in adenomatoid nodules and suspicious follicular lesions of the thyroid obtained by fine needle aspiration (FNA) cytology. Retrospective research was performed of 276 patients who underwent thyroid surgery after preoperative ultrasound-guided FNA diagnosis of either adenomatoid nodule, cellular follicular lesion, "suspicious for follicular neoplasm" or follicular neoplasm. Out of 276 patients, FNA reports showed 15 diagnoses (5%) of adenomatoid nodules, 73 (26%) cellular follicular lesions, 76 (28%) "suspicious for follicular neoplasm", and 112 diagnoses (41%) of follicular neoplasm. FNA reports were compared with pathohistological findings. In FNA reports of adenomatoid nodule (N = 15), there were seven (47%) pathohistological diagnoses (PHDs) of nodular goiter, and eight (53%) PHDs of follicular adenoma. In FNA reports of cellular follicular lesion (N = 73), there were 2 (3%) PHDs of thyroiditis, 32 (44%) PHDs of nodular go...