Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels
Michael Pusch
The Journal of Physiology, 2001
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KCC2 Chloride Transport Contributes to the Termination of Ictal Epileptiform Activity
Volodymyr Dzhala
eneuro, 2020
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Surface Expression and Single Channel Properties of KCNQ2/KCNQ3, M-type K+ Channels Involved in Epilepsy
Thomas Jentsch
Journal of Biological Chemistry, 2000
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Transcriptional Control ofKCNQChannel Genes and the Regulation of Neuronal Excitability
Mariusz Mucha
The Journal of Neuroscience, 2010
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Neuronal KCNQ potassium channels:physislogy and role in disease
Thomas Jentsch
2000
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Targeting BK (big potassium) channels in epilepsy
Prosper N'Gouemo
Expert Opinion on Therapeutic Targets, 2011
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Potassium Dynamics in the Epileptic Cortex: New Insights on an Old Topic
Maxim Bazhenov
The Neuroscientist, 2007
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Ionic Permeation and Conduction Properties of Neuronal KCNQ2/KCNQ3 Potassium Channels
Neil Marrion
Biophysical Journal, 2004
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Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
Rudolf Leuwer
The EMBO Journal, 2003
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K+ channelepsy: Progress in the neurobiology of potassium channels and epilepsy
Giuseppe Di Giovanni
2013
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Decreased Subunit Stability as a Novel Mechanism for Potassium Current Impairment by a KCNQ2 C Terminus Mutation Causing Benign Familial Neonatal Convulsions
Francesco Miceli, M. Soldovieri
Journal of Biological Chemistry, 2006
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Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy
Péter Halász
Brain Structure and Function, 2015
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Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy
Dorien Schepers
Annals of Neurology, 2014
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Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice
Serguei Skatchkov, Lilia Kucheryavykh
Epilepsia, 2010
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A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions
Алекси Алеков
Annals of Neurology, 1999
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Progressive Myoclonic Epilepsy-Associated Gene KCTD7 is a Regulator of Potassium Conductance in Neurons
Wendy Rodriguez
Molecular Neurobiology, 2011
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KCNQ potassium channels: drug targets for the treatment of epilepsy and pain
Rosemarie Roeloffs
Expert Opinion on Therapeutic Patents, 2004
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KCC2 activity is critical in limiting the onset and severity of status epilepticus
Tarek Deeb, Matt Kelley
Proceedings of the National Academy of Sciences, 2015
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Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia
Antonio Castellano
Journal of Medical Genetics
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M-type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit
Michel Lazdunski
FEBS Letters, 2000
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Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model
Anton Chizhov, Anatoly Buchin
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Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy
Anna Marcé-Grau
Epilepsia, 2018
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A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels
Affef Abidi
Neurobiology of Disease, 2015
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Atypical Gating Of M-Type Potassium Channels Conferred by Mutations in Uncharged Residues in the S4 Region of KCNQ2 Causing Benign Familial Neonatal Convulsions
Francesco Miceli, M. Soldovieri
Journal of Neuroscience, 2007
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Pathogenic variants in KCTD7 perturb neuronal K + fluxes and glutamine transport
Farrukh Abbas Chaudhry
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The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus
Thomas Jentsch
Proceedings of the National Academy of Sciences, 2010
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Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis
Anastasia Kosenko
Epilepsia
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Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice: Impaired Astrocyte Function in DBA/2 Mice
Russell Buono, Thomas Ferraro, Mikhail Inyushin
Epilepsia, 2010
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The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3
Michel Lazdunski
FEBS Letters, 1998
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Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy
Michael Pusch
Proceedings of the National Academy of Sciences of the United States of America, 2022
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