Dyspepsia and Helicobacter pylori (original) (raw)
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The Journal of medical research, 2016
Introduction: Since the discovery of H. pylori in 1983, the diagnosis and treatment of upper gastrointestinal diseases have changed greatly. A higher risk of the development of gastric cancer has been reported in subjects with positive serologic tests for H. pylori. Aims: Isolation of Helicobacter pylori from dyspeptic patient with or without ulcer and its correlation with endoscopic findings. Settings and Design: Prospective cross sectional study. Methods and Material: The study was conducted in the Department of Microbiology, SMIMS, Tadong, Gangtok for a period of 1 year (01.05.2013 – 30.04.2014) with patients with symptoms of dyspepsia. The parameters of investigation included upper gastrointestinal endoscopy, rapid urease test, Gram smear examination and isolation & identification of H. pylori by cultural technique. Results: Out of 50 patients, 32(64%) were positive for H. pylori by any of the three parameters. Of these, 26 (52%) were positive by RUT, 16(32%) by direct Gram stai...
Gastrointestinal Endoscopy, 2003
Dyspepsia, defined as pain or discomfort centered in the upper abdomen, is a common clinical problem. 1 In up to 60% of patients with dyspepsia, diagnostic investigation reveals no identifiable pathology, and a diagnosis is made of functional or nonulcer dyspepsia (NUD). 2 Epidemiologic studies show that between 30% and 60% of all patients with dyspeptic symptoms are infected with H pylori. 3-10 A number of meta-analyses 11-13 have investigated the effect of H pylori eradication on symptoms in patients with NUD. The results are inconsistent. Several studies, including the
Arquivos De Gastroenterologia, 2009
CONTEXT: It still remains an open debate whether Helicobacter pylori eradication is beneficial or not for the improvement of symptoms in functional dyspepsia. Differences in geographic distribution, the worldwide H. pylori genetic variability and the fact that the outcome of infection is strongly related to the virulence of the infecting strain are factors that might be driving ongoing controversies. OBJECTIVE: To study the correlation between gastric histology and H. pylori serology status in patients with dyspepsia. METHODS: This is a cross-sectional study where 40 consecutive dyspeptic patients (28 women and 12 men, mean age 48.5 years) with endoscopically normal stomachs were selected from the endoscopy unit at a university hospital in Recife, PE, Northeast of Brazil, between March 1998 and July 1999. Patients underwent gastric mucosal biopsy and serological tests (anti-Hp and anti-CagA antibodies). Gastric biopsies were examined using H-E and Giemsa stains and gastritis was classified and graded (mild, moderate or severe) according to "the updated Sydney System - Houston, 1994". RESULTS: Among 40 patients with dyspepsia the gastric histology revealed that about ¼ had moderate (25%) or severe (2.5%) gastritis. This subgroup of patients also had a greater positive frequency of anti-Hp (100% vs 41%; P = 0.0005) and anti-CagA (91% vs 58%; P = 0.09) antibodies when compared with those with normal histology (27.5%) or mild gastritis (45%). CONCLUSION: Since upper gastrointestinal endoscopy is part of the functional dyspepsia investigation and serology for anti-CagA antibody is not available in daily clinical practice, by biopsying gastric mucosa we would only be able to selectively apply H. pylori eradication therapy for those with histology that best correlate with virulent infecting strains (moderate or severe gastritis) - around ¼ of our study patients with dyspepsia.
Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia
Nepal Journal of Medical Sciences
Introduction: Helicobacter pylori (H. pylori) infection is a common disease with disparity in geography, age, race and socioeconomic status. Present study aims to assess the accuracy of noninvasive diagnostic tests. Methods: This is a hospital based cross sectional, observational study of 100 dyspeptic patients during November 2017- June 2018. Profile of dyspeptic patients were recorded in a proforma and accuracy of serology and stool antigen test for H. pylori was compared with histology detection in gastric biopsies. Results: Mean age of patients was 39.5±13.7 years with almost equal gender distribution. Prevalence of H. pylori was 56% with dyspeptic symptoms in gastric biopsies. Significant association of the infection was seen in patients with a longer duration of dyspepsia, pangastritis on endoscopy and chronic gastritis on histologic examination. Stool antigen test had good sensitivity (71%) and specificity (82%) for H. pylori detection compared with standard histological diag...
Background: There is a dearth of reports on the prevalence rate of Helicobacter pylori from the North-Central zone of Nigeria. This study aimed to determine the prevalence of H. pylori infection and its association with gastro-duodenal pathologies in patients presenting with dyspepsia in a tertiary hospital in North-Central Nigeria. Materials and Methods: One hundred and forty eight adult patients with dyspepsia underwent oesophagogastroduodenoscopy. Antral and corporal biopsy specimens were collected for histological examination. Diagnosis of H. pylori infection was made if Helicobacter-like organisms were identified in the processed specimens using Haematoxilin and Eosin, and Giemsa stains. Results: Of the 148 subjects studied, 68 (46.0%) were males and 80 (54.0%) females. The age range was 18 to 80 years with a mean of 49.5 ±15.1 years. H. pylori infection was found in 70 (47.3%) patients. Gastritis was the commonest endoscopic finding, 52 (35.1%). Others included: gastroduodenitis 42 (28.4%), normal findings 20 (13.5%), gastric cancer 11 (7.4%), duodenal ulcer 10 (6.8%), gastric ulcer 4 (2.7%) and gastroduodenal polyps 4 (2.7%). Twenty (38.5%) of the 52 patients with gastritis were infected with H. pylori compared to 27 (64.3%) of the 42 patients with gastroduodenitis. Seven (35.0%) of the 20 patients who had normal endoscopic findings tested positive for H. pylori infection. Conclusion: H. pylori infection has a moderately high prevalence among dyspeptic patients in Ilorin, irrespective of the gastroduodenal pathology seen at endoscopy. The association between H. pylori infection and endoscopic gastroduodenitis and histologic gastritis was significant (p=0.01 and 0.0006 respectively).
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Background: Helicobacter pylori is one of the most important infectious agents in the world. These bacteria infect 50% of the world population. Gastritis due to H. Pylori has been associated with the incidence of peptic ulcer, B cell primary lymphoma in the stomach, and gastric carcinoma. In dyspepsia, eradication of H. Pylori helps symptoms improvement and treatment cost efficiency. This study aimed to evaluate urease test in diagnosing H. Pylori infection in dyspepsia patients. It is expected that we could obtain a scientific evidence which can become the basis of routine use of urease examination in diagnosing H. Pylori infection.Method: This study used diagnostic study design. This study was performed in adult dyspepsia patients who underwent endoscopy examination in Gastrointestinal Endoscopy Centre Cipto Mangunkusumo General Hospital in January – November 2018. One biopsy sample was intended for rapid urease test using Helicotec which was performed according to the standard p...