Intrahepatic Protein C Activation During Reperfusion in Human Liver Transplantation Reduces Phagocyte Activation (original) (raw)

2004, Transplantation Journal

The matching was performed on 1300 kidney transplants from a single center population of transplants between 1996 and 2001. When samples were taken singly from 0 to 6 mismatch, there was an increased graft survival for each match grade examined. Most commonly, differences were more pronounced with time, however, 0,1,2 mismatch groups had smaller numbers. Therefore, 0,1,2 mismatch were combined as Group I and Ͼ2 mismatch as Group II. We found approximately 2% increase in graft survival per year for Group I as compared to Group II. This 2% was additive over the first 5 years examined. Interestingly, we could show that Group I was associated with lower average trough level for both immunosuppressed groups (neoral and tacrolimus). This was empirical and not done with any prospective immunosuppressive protocol. Furthermore, the patient survival was higher in Group I (pϭ.001). Conclusion: Matching from a single large center has shown efficacy at comparing 0,1,2 mismatches to Ͼ2 mismatch. Patient survival and lower immunosuppression was indicative of shorter hospital stay, less rejection, and fewer complications.