Protein Farnesylation-Dependent Raf/ERK Signaling Links To Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic ß-Cells Short title: Protein farnesylation in glucose-induced ERK activation and insulin secretion (original) (raw)

Protein Farnesylation-Dependent Raf/ERK Signaling Links To Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic ß-Cells Short title: Protein farnesylation in glucose-induced ERK activation and insulin secretion

2010

Abstract

Objective: Post-translational prenylation [eg, farnesylation] of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Herein, we investigated roles of protein farnesylation in the signaling steps ...

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