The significance of colonic mucosa (intestinal metaplasia) involving the urinary tract (original) (raw)

Cancer, 1987

Abstract

Although colonic type goblet cells are a relatively common component of reactive urothelial lesions and well-differentiated adenocarcinomas, complete replacement of areas of urothelium by benign appearing intestinal mucosa is a rare condition. All of the 11 documented cases occurred in association with abnormalities leading to chronic irritation and/or infection. In the three cases where the reported period of observation exceeded 2 years, all patients developed carcinoma. Despite its innocuous histology, widespread intestinal metaplasia apparently identifies a disturbed urothelium at high risk for cancer.

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