Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts (original) (raw)
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Edible seaweeds are rich in bioactive compounds such as soluble dietary fibers, proteins, peptides, minerals, vitamins, polyunsaturated fatty acids and antioxidants. Previously, seaweeds were only used as gelling and thickening agents in the food or pharmaceutical industries, recent researches have revealed their potential as complementary medicine. The red, brown and green seaweeds have been shown to have therapeutic properties for health and disease management, such as anticancer, antiobesity, antidiabetic, antihypertensive, antihyperlipidemic, antioxidant, anticoagulant, anti-inflammatory, immunomodulatory, antiestrogenic, thyroid stimulating, neuroprotective, antiviral, antifungal, antibacterial and tissue healing properties. In proposed chapter, we discussed various active compounds include sulphated polysaccharides, phlorotannins, carotenoids (e.g. fucoxanthin), minerals, peptides and sulfolipids, with proven benefits against degenerative metabolic diseases. Moreover, therapeutic modes of action of these bioactive components and their reports are summarized in this chapter.
Medicinal Value of Seaweeds-A Review
2014
Seaweeds are one of the most important living resources of the ocean and are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against the other settling organisms. These biogenic molecules impart the uniqueness of chemical diversity in seaweeds compared to other plants. Which owe them multitude of medicinal properties, because of that they are often been used as a food for people who are sick and has been credited with health-giving properties and have gained importance as medicinal sources. Present review highlights a state of art on the medicinal value of seaweeds and their exploitation scenario on a global scale.
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Seaweed is an enormous resource comprised with natural bioactive compounds comprise with several therapeutic effects including anticancer activity. In this context, the biochemical composition of seaweeds plays a major role. Many biochemical compounds extracted from seaweeds and crude extracts, such as aqueous, methanolic account mainly for the anticancer effect against several cancer cell line. In this contrast seaweed extracts inhibit cancer cell growth and proliferation by inducing apoptosis and inhibit metastasis activity. In this review, biochemical and anticancer properties of seaweeds are discussed and this will provide the basic information to develop a novel chemotherapeutic drug to challenge the cancer.
Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review
marine drugs, 2022
: Since ancient times, seaweeds have been employed as source of highly bioactive secondary metabolites that could act as key medicinal components. Furthermore, research into the biological activity of certain seaweed compounds has progressed significantly, with an emphasis on their composition and application for human and animal nutrition. Seaweeds have many uses: they are consumed as fodder, and have been used in medicines, cosmetics, energy, fertilizers, and industrial agar and alginate biosynthesis. The beneficial effects of seaweed are mostly due to the presence of minerals, vitamins, phenols, polysaccharides, and sterols, as well as several other bioactive com‐pounds. These compounds seem to have antioxidant, anti‐inflammatory, anti‐cancer, antimicrobial, and anti‐diabetic activities. Recent advances and limitations for seaweed bioactive as a nutraceutical in terms of bioavailability are explored in order to better comprehend their therapeutic develop‐ ment. To further understand the mechanism of action of seaweed chemicals, more research is needed as is an investigation into their potential usage in pharmaceutical companies and other applications, with the ultimate objective of developing sustainable and healthier products. The objective of this review is to collect information about the role of seaweeds on nutritional, pharmacolog‐ical, industrial, and biochemical applications, as well as their impact on human health
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity
Marine Drugs, 2018
Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity wil...
Bioactive Compounds of Seaweeds and Their Effects on Certain Types of Cancer
Avicenna Journal of Medical Biochemistry
Cancer is considered as one of the major health problems worldwide. So far, no completely effective method has been found for cancer treatment. Therefore, the rise of using natural products has been proposed as an alternative therapy in this regard. For many years, the seaweed has been a source of many functional bioactive compounds including polysaccharides, polyphenols, pigments, terpenes, and many others. These compounds have shown many bioactivities including anticancer activity against different kinds of cancer. Bioactive compounds obtained from the seaweed have been demonstrated to cause apoptosis in cancer cells and trigger cell cycle arrest with low cytotoxicity against normal cells. In this review, it was attempted to shed light on the anticancer activity of some seaweed-derived bioactive compounds.
Bioactivity of Some Egyptian Seaweeds Extract
International Journal on Environmental Sciences, 2015
This research aimed at screening in vivo antioxidant and anti-inflammatory activities as well as in vitro antimicrobial and cytotoxic activities in Codium tomentosum, Ulva lactuca and Hypnea musciformis, collected form the Suez Canal, Egypt. Samples were cleaned from epiphytes, washed, air dried and powdered. All the methanol/methylene chloride crude extracts showed a marked antioxidant effect compared to the reference drug vitamin E on alloxan induced diabetic rats and Hypnea musciformis (red algae) was the most potent (60.18%). Also, it showed the maximum anti-inflammatory activity in carrageenan-induced rat paw edema. Both extracts of H. musciformis and U. lactuca showed a wide spectrum antibacterial activity, and the highest activity appeared against Klebsiella pneumoniae (clinical culture). Moreover, all the crude extracts showed a promising cytotoxic activity (> 70%) against liver (HEPG2) and prostrate (PC3) cancer cell lines using Sulpho-Rhodamine-B (SRB) assay. The ethyl ...
2019
The global economic effect of the five driving chronic diseases-malignancy, diabetes, psychological instability, CVD, and respiratory disease- could reach $47 trillion throughout the following 20 years, as indicated by an examination by the World Economic Forum (WEF). As per the WHO, 80% of the total people principally those of developing countries depend on plant-inferred medicines for social insurance. The indicated efficacies of seaweed inferred phytochemicals are demonstrating incredible potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and a few cancers. Hence, WHO, UN-FAO, UNICEF and governments have indicated a developing enthusiasm for these offbeat nourishments with wellbeing advancing impacts. Edible marine macro-algae (seaweed) are of intrigue in view of their incentive in nutrition and medicine. Seaweeds contain a few bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have useful well-being ...
Marine seaweeds are important sources of drugs with several pharmacological characteristics.The present study aims to evaluate the antitumor and antitumor immunological potentials of the extracts from Padina pavonia and Jania rubens inhibiting the Egyptian marine coasts. Hep-G2 cell lines used for assessment of the antitumor efficacy of Padina pavonia and Jania rubens extracts in vitro, while Ehrlich ascites carcinoma (EAC) cells were applied to gain more antitumor immunity and antitumor insights of P. pavonia and J.rubens extracts in vivo. In vitro antitumor potentials of P. pavonia and J. rubens extracts were analyzed against human liver cancer Hep-G2 cells by MTT and trypan blue exclusion assays. In vivo antitumor immunological potentials of P. pavonia and J. rubens extracts at low, high, and prophylactic doses were analyzed by blood counting and flow cytometry in mice challenged with Ehrlich ascites carcinoma (EAC) cells. In vitro results revealed that P. pavonia and J. rubens e...
Therapeutic health booster: seaweeds against several maladies
Seaweeds (marine macro algae) are extremely important oceanic resource having unique secondary metabolites. They have the potential for supporting industrial development as being source of many essential substances such as pharmaceuticals, cosmetics, nutritional supplements etc. Seaweeds offer a wide range of therapeutic possibilities was established only some decades ahead. Several pharmacologically important metabolites have been discovered from seaweeds in recent years, the exploitation of seaweeds for therapeutically active molecules is still in its embryonic stage. In order to harness the rich therapeutic potential of seaweeds the present limited use needs to be diversified into several applications. Present review highlights a state of art on the medicinal value of seaweeds and their exploitation scenario on a global scale.