Nanoparticles for therapy of Alzheimer Disease (original) (raw)

NAD project (large cooperative; 19 partners, funded by the E.C. , FP72007-2013, G.A. n° 212043) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by creating different multiple-functionalized nanoparticles, able to bind, detect and remove β-amyloid peptide (Aβ) from the brain and from the blood. The results obtained so far show the ability of liposomes functionalized to bind Abeta, to cross the blood-brain barrier either in vitro and in vivo and to reduce the Aβ burden from the brain of transgenic animal models of the disease, thus opening new vistas for the possible therapy of Alzheimer Disease in humans.