Recent Developments in Self Emulsifying Drug Delivery System (original) (raw)
Related papers
A REVIEW ON SELF-EMULSIFIED DRUG DELIVERY SYSTEM
Improving oral bioavailability of low poorly water soluble drugs using self-emulsifying drug delivery systems (SEDDS) possess significant potential. Oral bioavailability of hydrophobic drugs can be improved using SEDDS, and appears most promising. Their dispersion in gastro intestinal (GI) fluid after administration forms micro or nano emulsified drug which gets easily absorbed through lymphatic pathways bypassing the hepatic first pass metabolism. Parameters like surfactant concentration, oil to surfactant ratio, polarity of emulsion, droplet size and charge on droplet plays a critical role in oral absorption of drug from SEDDS. For hydrophobic drug substances that exhibit dissolution step as rate limiting for absorption, SEDDS offer an improvement in rate and extent of absorption and gives more reproducible plasma concentration time profiles. Use of combined in vitro dispersion and digestion methodologies has enabled a much improved understanding of role of intestinal lipid processing on solubilization behavior of lipid based drug delivery systems (LBDDS). The article gives a brief view on the solid lipid nanoparticles and its evaluation.
Self Emulsifying Drug Delivery System: A Novel Approach for Drug Delivery
The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including co-solvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract. Recently, much attention has been focused on SEDDS to improve the oral bioavailability of poorly aqueous soluble drugs. The sole objective of pharmaceutical science is to design successful dosage forms which fulfill the therapeutic needs of the patients effectively. SEDDS are liquid to semisolid in nature, but it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into solid dosage forms such as pellets, tablets, capsules, microspheres, micro-beads, nanoparticles etc without affecting drug release property. After administering the drug gets released and self emulsify in the GI tract. This article gives an overview of the new excipients used in SEDDS, types of formulations and SE dosage forms with characterization methods and pharmaceutical applications of SEDDS.
Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development
Lipid-based formulations, such as Self-Emulsifying Drug Delivery Systems (SEDDS), are an important tool for lipophilic drugs and offer the potential for enhancing drug absorption and oral bioavailability. SEDDS are a promising approach for the formulation of drug compounds with poor aqueous solubility. These systems are easily manufactured and physically stable mixtures of oil, surfactants, co-surfactants and solubilized drug substances that are administered orally in soft or hard gelatin capsules. In the gastrointestinal tract environment, these systems spontaneously emulsify. This review focuses on SEDDS formulations, describes their different types and presents case studies in which enhanced bioavailability were demonstrated in vivo using this formulation system.
SELF-EMULSIFYING DRUG DELIVERY SYSTEM: AN ADVANCED DRUG DELIVERY OF POORLY SOLUBLE DRUG
Self-emulsifying drug delivery systems (SEDDS), are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants. It can be used can be used for the design of formulations in the novel drug delivery system in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be administered orally in soft or hard gelatin capsule form. Formulation of SEDDS will form fine emulsions or micro-emulsions in the gastrointestinal tract with mild agitation which occurs due to gastric motility. Advancement in this formulation systems will enhance the bioavailability as the solubility tends to increase and gastric irritation is minimized thus the problems encountered in manufacturing highly lipophilic drug is minimized. About 40% of hydrophobic drugs compounds of about 40% implies that this entity shows poor solubility and formulation of SEDDS is very advantageous in the pharmaceutical industry. Parameters like surfactant concentration, oil/surfactant ratio, and polarity of the emulsion, droplet size and charge should be considered in oral absorption of drug formulated from SEDDS. This article reviews on the components of SEDDS, various dosage forms, formulation, characterization, preparation, advantages and disadvantages as well biopharmaceutical aspects of SEDDS.
A Review on Solid Self Emulsifying Drug Delivery System
Journal of Biomedical and Pharmaceutical Research, 2013
Self-emulsifying drug delivery system (SEDDS) is one of the most popular and commercially viable formulation approaches for enhancing solubility of poorly water soluble drugs. SEDDS are isotropic mixtures of oil, surfactant and co-surfactant which are generally present in liquid or semisolid form. Solid SEDDS are solid forms of liquid SEDDS converted into solid by suitable means. These solid SEDDS are considered more stable over liquid SEDDS, also solid forms improve handling, packaging and storage. The aim of this review is to discuss various methods of preparation of solid SEDDS and different existing drug delivery systems which incorporated solid SEDDS to obtain advantage of both the systems.
Solid Self Emulsifying Drug DeliverySystem: A Novel Approach
2015
The new chemical entities discovered by the pharmaceutical industry up to 40% to 50% are poorly soluble or lipophilic compounds, which leads to poor oral bioavailability. Currently a number of technologies are available to deal with the poor solubility, dissolution rate and bioavailability of insoluble drugs. Recently much attention has been paid to lipid based formulations with particular emphasis on self emulsifying drug delivery system (SEDDS), to improve the oral bioavailability of lipophilic drugs. Self emulsifying formulations are mixtures of oils and surfactants, ideally isotropic, and sometimes containing co-solvents, which emulsify spontaneously to produce fine oilin- water emulsion when introduced into aqueous phase under conditions of gentle agitation. The present review examines the recent advances in Solid SEDDS (S-SEDDS) with regard to the selection of lipid systems for current formulations, solidification techniques by adsorbing agents and the development of solid SE ...
Applications of Self Emulsifying Drug Delivery Systems in Novel Drug Delivery- A Review
2014
Self-emulsifying drug delivery systems are isotropic mixtures of oils, surfactants and co-surfactants. Sometimes co-solvents are also incorporated to increase the solubility. That is why SEDDS are also becoming important tool in novel drug delivery since last couple of years. The problems of low bioavailability issues associated with poorly water soluble drugs can be easily solved by SEDDS. The bioavailability of BCS class -II and class-IV can be enhanced by these systems. These systems form fine emulsions (micro-/nano-emulsion) in gastro-intestinal tract (GIT) with mild agitation provided by gastric mobility. The increased surface area and amphoteric nature of SEDDS lead to increase in bioavailability. SEDDS also minimizes the gastric irritation. The hepatic first-pass effect can be bypassed by these systems because the drugs can subsequently be absorbed by lymphatic pathways. In this review we present a report on the formulation, evaluation and dosage forms and applications of sel...
Self Emulsifing Drug Delivery System (Sedds) -A Review
2020
Self-emulsifying drug delivery systems instigated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. The innovatory drug delivery possibilities presented by these distinctively simplified systems in terms of muco-adhesiveness and zeta-potential changing capacity lead the way forward to groundbreaking research. Contrarily, SEDDSs destined for topical/transdermal drug delivery has received limited attention. Therefore, this review is focused at utilizing principles, established during development of oral SEDDSs, and tailoring them to fit evaluation strategies for an optimized topical/transdermal drug delivery vehicle. This includes a detailed discussion of how the authentic pseudo-ternary phase diagram is employed to predict phase behaviour to find the selfemulsification region most suitable for formulating topical / transdermal SEDDSs. Additionally, special attention is given to the manner of characterizing oral SEDDSs compared to topical/transdermal SEDDSs, since absorption within the gastrointestinal tract and the multi-layered nature of the skin are two completely diverse drug delivery territories. Despite the advantages of the topical/transdermal drug administration route, certain challenges such as the relatively undiscovered field of skin metabolomics as well as the obstacles of choosing excipients wisely to establish skin penetration enhancement might prevail. Therefore, development of topical/transdermal SEDDSs might be more complicated than expected. Keywords. Self-emulsifying drug delivery systems. 1. BACKGROUND OF SEDDS. SEDDS are promising approach for oral delivery of poorly water-soluble compounds. It can be achieved by pre-dissolving the compound in a suitable solvent. The oral drug delivery of hydrophobic drugs can be made possible by SEDDS. The main benefit of this approach is that pre-dissolving the compound overcomes the initial rate limiting step of particulate dissolution in the aqueous environment within the GI tract. However, a potential problem is that the drug may precipitate out of solution when the formulation disperses in the GI tract, particularly if a hydrophilic solvent is used. If the drug can be dissolved in a lipid vehicle there is less potential for precipitation on dilution in the GI tract, as partitioning kinetics will favors the drug remaining in the lipid droplets. SEDDS are used as potential drug delivery vehicles because of their thermodynamic stability; reversibility, simple manufacturing, and scale up feasibility, and do not
More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is rapidly transported into the circulation. SDLFs consist of a mixture of oil and surfactant, in which active drug moiety is incorporated. They get emulsified under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract on mixing with biological fluids. In this review article introduction, advantages and uses of SDLFs to enhance the dissolution and oral bioavailability are overviewed.
DESIGN AND EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS
Neuroquantology, 2021
The aim of the present work was to prepare SEDDS to sustain the drug release. Various oils, surfactants and co-surfactants werescreened for their suitability in the formulation of SEDDS. Based on the solubility studies,Oleic acid was selected as oil phase, Tween20 as a surfactant, PEG 600 as a Co-surfactant. Pseudo ternary phase diagrams were constructed to determine the nano emulsion area for eachformulation. SEDDS can be effectively formulated by adsorption technique. SEDDScould sustain the drug release.A nano emulsion gel wasdeveloped to enhancebioavailability of the drug. The in vitro drug release of SEDDS was sustained (for 24 hours) whencompared to marketed formulation. Pharmacodynamic studies performed bypaw volume method indicated significant (p< 0.05) inhibition in paw edema (75%) for the testformulation after 4hours as compared to the standard formulation (56%.