НELICOBACTER PYLORI В СВЕТЕ ПАТОГЕНЕЗА МЕЖОРГАННЫХ СВЯЗЕЙ ПРИ ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЯХ (original) (raw)
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The alimentary tract of a healthy human being is a special ecosystem and stomach with its acid environment occupies a unique place in this system. According to the statistical data of last ten years, about 5-10 % of population in developed world is suffering from Chronic Gastritis and Peptic Ulcer. These diseases are among main diseases also in Georgia, especially in Samegrelo Region. They affect both men and women almost with the same frequency. According to the research of both foreign and our scientists of last ten years, Helicobacter pylori plays crucial role in the etiology and pathogenesis of these diseases. There is a link in 85-90 % of cases. Due to action of H. pylori defense mechanisms of mucous membranes deteriorate and aggressive factors increase. At the International Congress of Gastroenterologists (Australia, 1990) so called " Sydney Classification " was adopted for different types of Gastritis. This classification names a special form of Gastritis – H. pylori-associated Chronic Gastritis or " B Gastritis ". European Research Group for H. pylori and distinguished European gastroenterologists adopted so called " Maastricht Agreement " in 1996 (Maastricht, Netherlands). This agreement was principally new and it covers essential aspects of H. pylori eradication. The etiology of Chronic Piloro-Antral Gastritis is completely It is true that the role of infection in etiology of Peptic Ulcer is doubtless, but up to now the experimental model of Peptic Ulcer does not exist; development of ulcer does need presence of other co-factors; H. pylori is a semi-pathogenic microbe which is often accustomed to life in acid gastric environment. During evolution long time ago a human being and H. pylori met each other and in contrast to other microbes it managed to adapt to the living conditions in acid gastric environment. It colonized gastric epithelium and built a symbiotic relationship with the human being; Peptic Ulcer should be regarded as a gastroenterological and not an infectious disease and H. pylori should be considered as an important factor, especially as a local important factor; H. pylori or any other infectious agent cannot be a sole cause of Peptic Ulcer. This microbe can reveal its pathologic nature only if gastric mucosa is damaged by other factors; Epidemiological as well as experimental data show that one of the causes of Chronic Gastritis and Peptic Ulcer among others is alimentary factor.
ПАРОВАЯ БЕСКИСЛОРОДНАЯ ГАЗИФИКАЦИЯ В УСЛОВИЯХ ПОЛИГЕНЕРАЦИИ
Izvestiya Tomskogo Politekhnicheskogo Universiteta Inziniring Georesursov, 2021
Актуальностьисследования связана с перспективами глубокой переработки твердого топлива при нетрадиционном способе получения перегретого водяного пара в условиях тепловых электрических станций при осуществлении паровой бескислородной газификации. Это позволит создать на тепловых электрических станциях высокоэффективные энерготехнологические предприятия с производством не только тепловой и электрической энергии, но и разнообразных химических веществ, в частности водорода и продуктов синтеза Фишера–Тропша. Цель:обосновать возможность и перспективы осуществления процесса паровой бескислородной газификации в условиях получения пара на тепловых электрических станциях в сравнении с широко применяемым процессом парокислородной газификации;сравнить процесс парокислородной и паровой бескислороднойгазификации по стоимости химических веществ, получаемых из синтез-газа в процессе синтеза Фишера–Тропша. Объекты:процесс паровой бескислородной газификации твердых топлив в условиях полигенерации;спо...
АСПЕКТЫ БИОЛОГИЧЕСКОГО РАЗНООБРАЗИЯ НА СЕВЕРО-ЗАПАДЕ ПАЛЕОАРКТИКИ
Ростокский Университет, отделение биологических наук) Введение Биологическое разнообразие }Jвляется одним из основных свойств жиз ни. Биосфера не покрывает земную поверхность как однородный слой или масса. Напротив, жизнь встречается на многочисленных уровннх (в ком партментах) постепенно возрастающей сложности: биохимические структу ры и цепи, органеллы клетки, организмы, популяции, виды, сообшества (Kinzelbach, 1998; Tukay et al .. 2001 ). Эти отдельные компартменты всегда обладают опрсделеннной вариатив ной шириной. С одной стороны, именно это делает возможной эuолюuию путем селек ции наиболее приспособленных индивидоu под воздействием меняю1нихсн во времени и в пространстве условий. В резулыате рюнообра:шые ресурсы для поддержания жизни используются наиболее оптим<шьно. С другой стороны, огромное биологическое разнообразие является ос новой того, чтобы определенная часть живых сушеств выживает в периоды значительных катастроф окружающей среды, вызываемых, к примеру, па дением комет или астероидов. Согласно теории «Неокатастрофизма»
О ПАТОГЕНЕЗЕ ДИАБЕТИЧЕСКОЙ ПОЛИНЕЙРОПАТИИ
One of the serious complications of diabetes is diabetic polyneuropathy. Diabetic polyneuropathy is a disease characterized by progressive death of nerve fibers leading to loss of sensation and development of foot ulcers. The article summarizes the data of literature encompassing the pathogenesis of diabetic polyneuropathy, the principles of diagnosis of this complication. Currently, there are four theories of pathogenesis of diabetic polyneuropathy: metabolic, vascular, hereditary and the disturbed immune. The main pathogenic factor in the development of diabetic polyneuropathy is hyperglycemia, which leads to neuronal damage. Developing phenomenon of “oxidative stress” is a major cause of late complications of diabetes, including generalized lesions of the peripheral nerves.
СВЯЗЬ ПАРАМЕТРОВ ОПУХОЛЕВОГО НЕОАНГИОГЕНЕЗА С ЛИМФОГЕННЫМ МЕТАСТАЗИРОВАНИЕМ ПРИ РАКЕ ПРЯМОЙ КИШКИ
2017
Angiogenesis (neoangiogenesis) characterized by the formation of new blood vessels from pre-existing vessels is the main condition for the intensive growth of the primary tumor. This process is characterized by a sequence of events beginning with vasodilation, separation of pericytes from the vascular wall with subsequent proliferation of endotheliocytes and formation of vascular glomeruli surrounded by stromal cells. Evaluation of the density of microvessels, as well as «vascular kidneys» (clusters of endotheliocytes) is the most widely used method for quantifying intracellular angiogenesis. The purpose of the study was to analyze the expression characteristics of markers of neoangiogenesis (CD34 and VEGFR) in tumor tissue and to evaluate their relationship with the parameters of lymphogenous metastasis in colorectal cancer. Material and methods. Surgical specimens from 130 patients with ypT1–4N0–2M0 stage of rectal cancer, who were treated at the Thoracic and Abdominal Department ...
2015
Piloid astrocytoma (PA) is a low-grade (WHO grade I) glial tumor that is more common in pediatric patients. According to the data of many authors, stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) promote long-term remission or delayed tumor progression in patients with inoperable tumors after incomplete removal of a tumor and with its recurrence. So it is urgent to determine the place and role of SRS and SRT in the combination treatment of patients with deeply located PA. Subjects and methods . In the period April 2005 to May 2010, the Department of Radiology and Radiosurgery, Neurosurgery Research Institute, Russian Academy of Medical Sciences, treated 101 patients diagnosed as having intracranial PA. Of them there were 70 children (aged 17 years inclusive) and 31 adults; 51 men and 50 women. The median age was 15.1 years (9.8 years for children and 28.7 years for adults). Tumor was histologically pre-verified in 90 (89.2 %) patients (tumor ablation in 83 cases a...
ПАРАМЕТРЫ ОПТИЧЕСКИХ ФИЛЬТРОВ НА ДИЭЛЕКТРИЧЕСКИХ МИКРОРЕЗОНАТОРАХ С КОЛЕБАНИЯМИ ШЕПЧУЩЕЙ ГАЛЕРЕИ
Parameters of the Optical Filters on Dielectric Micro-resonators with Whispering Gallery Modes, 2015
Parameters of the Optical Filters on Dielectric Micro-resonators with Whispering Gallery Modes Electrodynamics analysis of the wide class band pass and band stop filters, constructed on spherical and disk dielectric microresonators with whispering gallery modes (WGM) is considered. S-matrix frequency responses of the multiple-unit filters are calculated and discussed. WGM resonators material features are taken into account