Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature (original) (raw)
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Oncology letters, 2012
We analyzed the clinicopathological characteristics and therapeutic outcomes of patients with metastatic gastric tumors arising from renal cell carcinoma (RCC) to identify post-therapy prognostic factors. A total of 22 patients who were treated for metastatic gastric tumors arising from RCC were included in the study. A retrospective review was performed on the clinical characteristics of this disease. The median time interval from radical excision of the primary tumor to the detection of gastric metastasis (IGM) was 6.3 years. The overall 1- and 3-year survival rates were 52.6 and 21.0%, respectively, and the median survival time was 19 months. Compared with patients with an IGM of <6.3 years, patients with an IGM of ≥6.3 years showed a significantly longer median survival time (5 vs. 24 months; P=0.017). The median tumor size was significantly greater in patients with multiple metastases compared with those with solitary metastasis (4 vs. 2 cm; P=0.036). The incidence of patien...
Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy
Türk Üroloji Dergisi/Turkish Journal of Urology, 2016
Renal cell carcinomas account for 2-3% of malignant neoplasms in adults. The lung, soft tissues and bone represent the most frequent sites of distant metastasis in renal cell carcinoma. Gastric metastasis is rare. Our case was a 72-year-old man with complaints of fatigue and loss of appetite. In history, he had unergone radical nephrectomy due to renal cell carcinoma in 1993. A polypoid lesion was observed in upper gastrointestinal endoscopy. Histopathology of gastric biopsy specimen was reported as renal cell carcinoma. In English literature, there are 50 cases diagnosed as gastric metastasis from renal cell carcinoma. To date, there are only 4 cases with extremely late gastric metastasis of renal cell carcinoma. Herein, we present a rare case which underwent radical nephrectomy due to renal cell carcinoma and found to have gastric metastasis at 20. year of his follow-up.
Gastrointestinal Metastases From Primary Renal Cell Cancer: A Single Center Review
Frontiers in Oncology, 2021
Introduction: Digestive metastases (DMs) from renal cell cancer (RCC) are rare. Over the past decade, the overall survival of metastatic RCC (mRCC) has been improved by tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors. The main objective of this study was to assess the incidence of metastases of the digestive tract in this new field of treatment. The secondary objectives were to evaluate the clinical characteristics, prognosis, treatments used for DMs, and median time between the diagnosis of RCC or mRCC and DMs.Materials and Methods: A retrospective analysis of data collected from all patients with mRCC between 2007 (the time of TKI was a standard of care) and 2019 was carried out at the Paoli-Calmettes Institute (Marseille, France). Computer research software using artificial intelligence (ConSoRe®) was used to identify patients and assess their characteristics.Results: Between January 2007 and December 2019, 11 out of 660 (1.6%) mRCC patients had metastases of t...
Atypical Locations of Renal Cell Carcinoma Metastases to the Pancreas and Duodenum
Research and Reports in Urology, 2021
Introduction: Pancreatic tumors account for a small percentage of all malignancies. Most of them are primary and originate from cells of the exocrine pancreas. The remaining primary changes are neuroendocrine tumors. The pancreas may also be a target of metastatic lesions. The most common cancer that metastasizes to the pancreas is renal cell carcinoma. Case Studies: The paper presents two cases of rare metastases to organs of the abdominal cavity: the first patient treated surgically due to two metastatic lesions of renal cell carcinoma in the pancreas, diagnosed many years after radical nephrectomy. The second case of high gastrointestinal obstruction in the course of metastasis of renal cell carcinoma to the duodenum. The first patient underwent distal laparotomic resection of the pancreas. The second patient underwent resection of the duodenum and the first jejunal loop with sideto-side duodeno-jejunal anastomosis. Both patients remain under oncological supervision. Conclusion: Patients after radical nephrectomy due to renal cell carcinoma require longterm systematic monitoring. Due to the anatomical position of the pancreas and duodenum as well as the number, location and size of metastatic lesions, the course of the disease may be initially asymptomatic or oligosymptomatic. Aggressive surgical treatment of pancreatic metastases creates opportunities for long-term survival.
Metastatic Renal Cell Carcinoma to Pancreas: Case Series and Review of the Literature
Diagnostics
Metastasis to the pancreas represents a small proportion of all pancreatic malignancies. Among primary tumors that metastasize to the pancreas, renal cell carcinoma (RCC) is one of the most common causes of metastatic pancreatic lesions. We herein report a case series of three patients with pancreatic metastasis from RCC. The first is a 54-year-old male with a history of left nephrectomy for RCC, in whom an isthmic pancreatic mass suggestive of a neuroendocrine lesion was found during oncological follow-up. Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) identified pancreatic metastasis of RCC and the patient was referred for surgery. The second case is a 61-year-old male, hypertensive, diabetic, with left nephrectomy for RCC six years previously, who complained of weight loss and was found with a hyperenhancing mass in the head of the pancreas and a lesion with a similar pattern in the gallbladder. EUS-FNB from the pancreas proved to be a metastatic pancreatic lesion. C...
Solitary, Late Metastatic Recurrence of Renal Cell Carcinoma to the Pancreas: A Case Report
Cureus, 2020
Renal cell carcinoma (RCC) accounts for 3% of all adult malignancies and is known for metastatic initial presentation, unpredictable metastatic pathway, and late recurrence postcurative resection. We report a case of solitary late metastatic renal cell carcinoma to the pancreas more than 10 years after radical nephrectomy. A high index of suspicion must be maintained to detect RCC late recurrence and metastasis to rare and atypical locations. A lifelong follow-up is recommended.
Metastasis of Renal Cell Carcinoma to the Pancreas 13 Years Postnenhrectomv
Gastroenterology & Hepatology, 2011
Metastasis of Renal Cell Carcinoma to the Pancreas 13 Years Postnephrectomy M etastatic lesions in the pancreas are uncommon, accounting for only 5% of all pancreatic malignancies. Renal cell carcinomas (RCCs) account for 2% of all cancers and have a predilection to metastasize to rare locations, including the pancreas. RCC is the most common primary tumor leading to solitary pancreatic metastasis. Although the majority of metastases occur within 3 years of radical nephrectomy, the appearance of metastatic disease many years after nephrectomy is a wellknown feature of RCC. Since most pancreatic metastases are asymptomatic, routine long-term radiologic surveillance is necessary. We present a case of metastatic RCC to the pancreas that occurred 13 years postnephrectomy. Case Report A 67-year-old asymptomatic woman was referred to our institution for evaluation of a new mass in the tail of the pancreas that had been identified via computed tomography (CT). Her past medical history was significant for diabetes mellitus, hypertension, peripheral vascular disease, carotid artery stenosis, coronary artery disease status post-bypass surgery, and a 5.5-cm RCC of the left kidney, for which she had undergone a left nephrectomy in 1997 (approximately 13 years earlier). Routine, noncontrast CT surveillance found interval growth of a previously noted right renal mass lesion and development of a new mass in the pancreatic tail. A repeat CT scan performed with intravenous contrast showed 2 cystic lesions in the right kidney and a 5.8-cm × 4.9-cm × 3.6-cm mass in the tail of the pancreas. The pancreatic mass appeared isodense to the
Late Onset of Pancreatic Metastases from Renal Cell Carcinoma. A Case Report
PRILOZI, 2020
Metastasis of renal cell carcinoma (RCC) to the pancreas is a rare entity accounting only 0.25–3% of all pancreatic tumors. We present a rare case of isolated three focal pancreatic metastases from RCC, occurring 15 years after the left nephrectomy. The majority of the pancreatic metastases are asymptomatic, as it was in case of our patient excluding the weight loss for the last three months. We demonstrate the importance of the medical history, radiological examinations, histological and immunohistochemical analysis in making a definitive diagnosis.