LATE-BREAKING ABSTRACT: Biomarkres in exacerbations of chronic obstructive pulmonary disease (ECOPD) (original) (raw)
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Hematological and Inflammatory Biomarkers among Stable COPD and Acute Exacerbations of COPD Patients
Sultan Qaboos University Medical Journal
Objectives: Chronic Obstructive Pulmonary Disease (COPD) is heterogeneous in nature. Acute exacerbation of COPD (AECOPD) is diagnosed clinically which is subjective and clinical judgment may vary from clinician to clinician. Since chronic inflammation underlies the pathogenesis of COPD, markers of inflammation have generated lot of interest for their potential to be used as biomarkers of COPD. This study aimed to assess the variation in levels of neutrophil lymphocyte ratio (NLR) and platelet indices in patients with stable COPD and acute exacerbation of COPD patients and its association with GOLD stages. Methods: This prospective analytical study was carried out in our tertiary care hospital from December 2018 to July 2020. About 64 subjects (32- stable COPD, 32- AECOPD) who satisfied study criteria were included. Blood sample was taken from stable and AECOPD patients and were compared. Results: It was observed that Neutrophil Lymphocyte Ratio, Platelet Distribution Width, Erythroc...
Journal of Medical Biochemistry
Summary Background Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have all been investigated as novel inflammatory markers of cardiac and oncological diseases, while there is only a limited number of studies investigating these markers in chronic obstructive pulmonary disease (COPD). In the present study we examine NLR, PLR; and other markers, such as eosinophil, MPV, plateletcrit (PCT), platelet distribution width (PDW), red cell distribution width (RDW), and C-reactive protein (CRP) in patients with stable and acute exacerbation of COPD. Methods Stable COPD (Group 1, n=140), COPD with acute exacerbation (Group 2, n=110), and healthy controls (Group 3, n=50) were included in the study. Leukocyte, CRP, hemoglobin (HB), RDW, platelet, MPV, PCT, PDW, neutrophil, lymphocyte, eosinophil, NLR, and PLR were analyzed in all groups. Results HB, leukocyte, platelet, neutrophil, eosinophil, MPV, PCT, CRP, NLR, and PLR were significantly...
2020
Aim: This study aimed to evaluate the severity of the disease using inflammatory markers in patients with Chronic Obstructive Pulmonary Disease (COPD) who admitted to the emergency department. Materials and Methods: 193 COPD patients who applied to the emergency department were included in this retrospective study. Patients were divided into two groups according to the severity of COPD. The presence of type 1 and type 2 respiratory failure was used to create Group 2 (severe, very severe, life-threatening) and in the absence, Group 1 (mild, moderate). Inflammatory markers such as Neutrophil / lymphocyte ratio (NLR), Platelet / lymphocyte ratio (PLR), Lymphocyte / monocyte ratio (LMR) and disease severity were evaluated for both groups. Results: The high COPD severity group (Group 2) had higher NLR and PLR values (p <0.001, p <0.001, respectively), and LMR values were lower (p <0.001). There was infection in 46.2% of Group 2, while this rate was 13.5% in Group 1 (p <0.001)...
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], 2008
Little is known about airway inflammatory markers in chronic obstructive pulmonary disease (COPD). The objective of the present study was to identify and try to correlate pulmonary and peripheral blood inflammatory markers in COPD. In a cross-sectional study on patients with stable COPD, induced sputum and blood samples were collected for the determination of C-reactive protein, eosinophilic cationic protein, serum amyloid A protein, alpha-1 antitrypsin (alpha-1AT), and neutrophil elastase. Twenty-two patients were divided into two groups according to post-bronchodilator forced expiratory volume in the first second (%FEV1): group 1 (N = 12, FEV1 <40%) and group 2 (N = 10, FEV1 > or =40%). An increase in serum elastase, eosinophilic cationic protein and alpha-1AT was observed in serum markers in both groups. Cytology revealed the same total number of cells in groups 1 and 2. There was a significantly higher number of neutrophils in group 1 compared to group 2 (P < 0.05). No ...