Transitional Cell Carcinoma Paranasal Sinuses- Significance (original) (raw)
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A rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Sino nasal malignancies account for only 0.2-0.8% of all malignancies and undifferentiated carcinoma is rare malignant tumour of sinonasal tract, with extremely poor prognosis. We report a case of sinonasal undifferentiated carcinoma which we managed by surgery followed by post-operative radiotherapy with concomitant platinum-based chemotherapy. Although the overall survival is about 20% at 5 years and there are frequent recurrences combined modality treatment is the best management option available at present.
Colliding tumor of the paranasal sinus
Allergy & rhinology (Providence, R.I.), 2013
Sinonasal malignant neoplasms comprise only 3% of all head and neck malignancies. Synchronous and metachronous tumors of the head and neck have been described, but rarely have there been reports of a single tumor with two distinct histologies. Here, we describe a case of a sinonasal malignant neoplasm with two distinct histologies. A case report and literature review was performed. We present a case of paranasal sinus neoplasm involving two malignant cell types. An 83-year-old woman presented with a 2-year history of symptoms suggestive of chronic sinusitis, which included nasal congestion and intermittent midface pressure. More recently, her symptoms progressed with the development of left-side epistaxis and she was found to have a mass in the left maxillary and ethmoid regions. A biopsy of the maxillary sinus mass revealed a moderately differentiated squamous cell carcinoma (SCC). She underwent complete resection of the lesion through an extended endoscopic approach. Final patholo...
Background: Inadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors. Material and Methods: Clinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor. Results: There were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy. Conclusions: Paranasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies.
Clinicopathological study of sinonasal malignancy
Bangladesh Journal of Otorhinolaryngology, 2010
This cross sectional study was done in the . In this study 30 patients of sinonasal malignancy were studied and to observe the clinicopathological pattern of sinonasal malignancy. The diagnosis was made by detailed history, clinical, radiological and histopathological examinations. In this study majority of the patients were within 40 to 70 years of age (77%). Male to female ratio was 2.33:1. Majority of the malignancy came from maxillary sinuses 15(50.00%); ethmoidal sinuses were involved in 8(26.66%) cases, multiple sinuses were involved in 5(16.66%). Neck node metastases was found in 4(14%) cases. Squamous cell carcinoma was the most common histological type (70.00%); the other less common histological types were adenoid cystic carcinoma (06.66%), adenocarcinoma (06.66%), Non-Hodgkin's lymphoma (06.66%), least frequent types were malignant fibrous histocytoma, transitional cell carcinoma, olfactory neuroblastoma.
Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence
Cancers, 2021
Simple Summary Sinonasal squamous cell carcinomas are a group of diverse tumors affecting the nasal cavity and paranasal sinuses. As a direct consequence of their rarity and heterogeneity, diagnosis is challenging, and treatment does not follow universally accepted protocols. Though surgery represents the mainstay of treatment, neoadjuvant and adjuvant therapies have pivotal roles in improving outcomes of patients treated with curative intent. Indications to endoscopic surgery have been expanding over the last three decades, but a considerable number of patients affected by sinonasal squamous cell carcinoma still need open surgical procedures. Management of the neck in patients affected by sinonasal squamous cell carcinoma is controversial. Curative-intended treatment of recurrent and/or metastatic tumors, alongside palliation of uncurable cases, represent poorly explored aspects of this disease. Abstract Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity a...
Undifferentiated Sinonasal Carcinoma-Case Report
Journal of Pharmacy and Pharmacology 7 (2017) 434-438, 2017
SNUC (undifferentiated sinonasal carcinoma) is a rare tumor. The exact cause of this cancer is not known. Patients usually have signs and symptoms of bleeding from the nose, runny nose, duplicate photos, symptoms of chronic sinus infections and nose, nasal obstruction, or facial pain. We reported a case of seventy year old patient with sinonasal undifferentiated carcinoma in the right maxillary sinus. Six months ago, the patient was conducted operations polyp in the right nasal hall. He had pain in the right side of his face and swelling in the mouth in the area of the upper jaw on the right side. The patient was operated tumor of the right maxillary sinus, with expansion in the ethmoid sinus, nasal cavity and infratemporal space. The neck dissection was done on the same side. Postoperatively, he received radiation therapy and chemotherapy. SNUC is very rare aggressive cancer that requires aggressive therapy. This cancer is considered in need of modified maxillary sinuses, as well as for modified sinus in polyps or after the operation of the same. Despite extensive surgery, radio therapy and implemented chemotherapy, the prognosis of these tumors is very poor.
Cancer of the nasal vestibule, nasal cavity and paranasal sinuses
B-ENT, 2005
The usual clinical presentation of sinonasal tumours includes symptoms that are indistinguishable from inflammatory sinus disease, namely nasal airway obstruction, pain, and epistaxis. Abnormal V1 and/or V2 sensations are a strong indication of the possibility of tumour. Computed tomography is the most reliable and informative imaging tool for evaluating the cancers of the paranasal sinuses. Magnetic resonance imaging is essential for tumour mapping because of the excellent tissue characterisation and the possibility of differentiating between neoplasms and retained secretions. A wide variety of histologies may be encountered, although squamous cell carcinoma (SCCA) is the most common. Radiation is a common adjuvant to surgery. The response of sinonasal tract tumours to radiation therapy varies with the stage and histology of the tumour. Rehabilitation after surgical resection may be accomplished with prosthodontics or reconstructive flaps. Bony erosion of the orbital walls does not...
Background The present study aimed to report the characteristics, prognostic factors, and treatment outcomes of 71 cases of malignant neoplasms of the sinonasal tract and literature review and analysis of major report series. Methods Seventy-one consecutive patients diagnosed with primary malignant neoplasm of the sinonasal tract that were treated and followed up at a university hospital between May 2000 and March 2008 were selected for the present study. Thirty-four patients were treated with surgery followed by a combination of chemotherapy and radiotherapy, 15 with surgery alone, 14 with combined radiotherapy and chemotherapy, six with radiotherapy alone, and two with surgery followed by radiotherapy. To find out the major series of related studies over the last 20 years, a literature review of PubMed was performed. In all, we found 42 major series including 8,164 patients with malignant neoplasms of the sinonasal tract. Results There were 35 women and 36 men ranging in age from 5 to 80 years, with a median age of 55 years at diagnosis. The primary sites included were paranasal sinuses in 51 and nasal cavity in 20. There were one case of stage I, 20 of stage II, 27 of stage III, and 23 of stage IV.
Management of malignant tumours of the paranasal sinuses
Indian Journal of Otolaryngology and Head & Neck Surgery, 1984
Observations stasis. Besides, one more case paranasal sinuses are fortunately undeveloped nodal metastasis a few common. Lewis (1972) mentioned Age and sex : The age of patients months after the treatment of primary that cancer of the nasal cavity and varied from 8 years to 75 years lesion in the maxillary sinus. Thus, paranasal sinuses comprise about 2% (Table I). nine cases had nodal involvement at of cancers of the human body. some stage of their disease. Of According to Sisson and Becker TABLE I these, eight cases had squamous-cell (1981), malignant tumours of the Age and sex prevalence-_ carcinoma and one had adenocarcinose and paranasal sinuses make up Age groups No. of cases noma. 0.5% of all body tumours and 3% of 0-20 years 8 all tumours of the respiratory tract.