Androgenetic alopecia and insulin resistance in young men: Androgenetic alopecia and insulin resistance (original) (raw)
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Androgenetic alopecia and insulin resistance in young men
Clinical Endocrinology, 2009
Background Epidemiological studies have associated androgenetic alopecia (AGA) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance. We carried out a case-control study in age-and weight-matched young males to study the link between AGA and insulin resistance using the homeostasis model assessment of insulin resistance (HOMA-IR) index or metabolic syndrome clinical manifestations. Methods Eighty young males, 18-35 years old, with AGA ‡ stage III in the Hamilton-Norwood classification, and 80 weight-and agematched controls were included. Alopecia, glucose, serum insulin, HOMA-IR index, lipid profile and androgen levels, as well as metabolic syndrome criteria, were evaluated. Results The HOMA-IR index was significantly higher in cases than controls. Nonobese cases had a higher mean diastolic blood pressure and a more frequent family history of AGA than nonobese controls. A borderline difference in the HOMA-IR index was found in obese AGA cases vs. obese controls [P ¼ 0AE055, 95% confidence interval (CI) 2AE36-4AE20 vs. 1AE75-2AE73]. Free testosterone values were significantly higher in controls than cases, regardless of body mass index (BMI). A statistically significant additive effect for obesity plus alopecia was found, with significant trends for insulin, the HOMA-IR index, lipids and free testosterone when BMI and alopecia status were used to classify the participants. Conclusions Our results support the recommendation for assessing insulin resistance and cardiovascular-related features and disorders in all young males with stage III or higher AGA, according to the Hamilton-Norwood classification.
Innovative Publication, 2016
Introduction: Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome, diabetes mellitus and hypertension and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. Insulin resistance (IR), metabolic syndrome (MS) are known to be independent risk factors for coronary heart disease (CHD). The aim of this study was to assess the strength of association between MS and/or insulin resistance in males with early-onset Androgenetic alopecia (AGA). Methods: A total of 50 male patients with premature AGA attending the dermatology outpatient department and satisfying the inclusion and exclusion criteria were recruited in the study. Equal number of normal age and gender matched patients attending the dermatology OPD were taken as control group. A detailed history of the patients as per the prepared questionnaire was taken. Elaborate general, physical and systemic examination were carried out and recorded in standard proforma. Complete examination of scalp was done with emphasis on pattern and severity of hair loss. Hair loss was graded according to Hamilton-Norwood scale. Anthropometric and blood pressure measurement was done according to structured proforma. Fasting blood samples were collected and fasting insulin level, fasting blood sugar levels, high density lipoproteins, triglycerides were determined. Results: In this study, majority of patients with early onset AGA were in the age group of 22-24 years. Most common grade of hair loss was grade III a (32%) of Hamilton-Norwood scale of hair loss. 5 out of 50 cases (10%) and 2 out of 50 controls (4%) had shown association with insulin resistance and the difference between the groups was statistically insignificant (p= 0.23). 15 out of 50 cases (30%) and 4 out of 50 controls had shown association with metabolic syndrome and the difference between the group was statistically significant (p= 0.005). Conclusion: In our study, majority of patients with early onset AGA were in age group 22-24 years. 31% of cases had family history of AGA. Majority of the patients had stage III of Hamilton-Norwood scale of hair loss. Male patients with early onset AGA were not associated with IR. Metabolic syndrome was associated with male patients with early onset AGA.
Early Androgenetic Alopecia and Insulin Resistance-A case control study
Background: In Androgenetic alopecia AGA, androgens induce miniaturization of hair follicles in those genetically predisposed to baldness. The previously known association between Androgenetic Alopecia AGA and cardiovascular risk factors raises a question of common pathogenetic mechanism of these disorders. Aim: To study the association of Insulin resistance and metabolic syndrome in early onset AGA in young males Materials and Methods: This was a case control study with 30 participants in each group. Young males between 18 and 35 years of age were included in the study. Participants in the cases group had AGA greater than stage 3. Blood pressure, anthropometry, fasting insulin and glucose levels in blood, lipid profile, total and free testosterone and TSH were investigated for all participants. Insulin resistance was calculated using HOMA-IR and metabolic syndrome criteria devised by National Cholesterol Education Program Adult Treatment Pannel III NCEP ATP III was used. Results: Cases had a higher mean diastolic blood pressure and a more frequent family history of AGA than controls. Total and free testosterone levels were significantly more in participants with AGA than controls. There was no significant difference in Insulin resistance and Metabolic syndrome criteria between the cases and controls but the prevalence of Insulin resistance IR and metabolic syndrome MS increased with the severity of AGA. Conclusion: In conclusion, more studies are required in order to objectively clarify whether early AGA can be attributed to dyslipidaemia due to androgens, IR alone, or MS due to IR. In the present study we could not establish a clear cut role of IR or MS, though the testosterones were significantly higher in the AGA participants suggesting the role of androgens.
International Journal of Research in Dermatology
Background: Androgenic alopecia is most common type of non-scarring alopecia in men. It is associated with high risk of cardiovascular events. Aim was to study the prevalence of metabolic syndrome in male patients of early onset androgenic alopecia.Methods: A case-control study was conducted at the dermatology out-patient department over a period of 6 months which included 100 patients of androgenic alopecia and 100 age matched controls. All subjects were aged 20 to 35 years and underwent detailed history, clinical examination including trichoscopic examination and measurement of waist circumference and blood pressure. Fasting blood sugar, triglyceride and high-density lipoproteins were tested following overnight fasting. Diagnosis of metabolic syndrome was based on criteria of national cholesterol education program (NCEP) adult treatment panel III. Chi square test was used as a test of significance. P value <0.05 was considered statistically significant.Results: Prevalence of me...
Androgenic alopecia and insulin resistance: are they really related?
Clinical and Experimental Dermatology, 2009
Androgenic alopecia is known to be androgen-dependent. Insulin is found in hair follicles and may play a role in the regulation of androgen metabolism and the hair-growth cycle. To compare the insulin resistance between people with androgenic alopecia and a control group. A case-control study was conducted with 97 cases in the patient and 87 in the control group. Serum fasting insulin level, fasting blood glucose, serum total cholesterol, triglyceride and high-density lipoprotein (HDL) were all measured in both groups. There was no difference in serum fasting insulin level, fasting blood glucose, serum total cholesterol, triglyceride, HDL and insulin resistance between the two groups (P > 0.05). Despite previous reports suggesting a link, our study found no significant relationship between insulin resistance and androgenic alopecia. Further studies are warranted.
Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits
Clinical, Cosmetic and Investigational Dermatology, 2020
The association of androgenetic alopecia (AGA) with cardiovascular risk factors including hypertension, smoking and high body mass index (BMI) has been investigated in several studies. However, the results are discrepant. The aim of the present study was to evaluate the association of AGA with anthropometrics, blood pressure and lifestyle habits. Patients and Methods: In this case-control study, 256 men with AGA and 256 agematched healthy controls were evaluated. Systolic and diastolic blood pressures, as well as anthropometric indices were measured. Data on lifestyle habits including smoking, hookah use and alcohol consumption were also collected. Results: Patients with AGA had significantly lower BMI and lower waist to hip ratio as compared to controls (p = 0.012 and p = 0.002, respectively). Other anthropometrics as well as mean systolic and diastolic blood pressures were not significantly different between the two groups. There was no significant difference between patients and controls in terms of lifestyle habits. Patients with severe AGA (Norwood-Hamilton classification type IV-VII) had significantly higher systolic and diastolic blood pressures as compared to those with mild to moderate AGA (Norwood-Hamilton classification type II, III), but the mean age of the former group was also significantly higher (p < 0.001). Conclusion: In contrast to some previous studies, our findings did not show a significant association between certain cardiovascular risk factors (such as hypertension and smoking) and AGA. Although lower BMI and lower waist to hip ratio were observed in the patient group, these values were within normal limits and therefore not biologically significant.
2020
Background: Androgenetic alopecia (AGA) is the most prevailing type of progressive hair loss. Thus far, some previous studies have investigated the correlation between AGA and metabolicsyndrome (MetS). However, due to the inconsistency of their results, our study aims at evaluating the association between AGA and MetS.Methods: Fifty two male patients with grade III-V AGA, based on Ebling’s scale, and 50 control subjects were enrolled in the present study. All participants were evaluated for the presenceof Mets based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).Results: The prevalence of MetS was 51.3% in AGA group and 17.8% in control group (P=0.003). Among MetS parameters, Systolic blood pressure (P=0.003) and waist circumference (P<0.001)were statistically significant in AGA patients compared to the control group.Conclusion: Our study demonstrated that the association between AGA and MetS is of great importance. Therefore, early detec...
International Journal of Research in Dermatology, 2017
Background: Androgenetic alopecia (AGA) is a common form of patterned hair loss characterized by transformation of terminal hair of the scalp to vellous hair mediated mainly by androgens. Premature androgenetic alopecia can be defined as androgenetic alopecia developing before 35 years of age and presenting with at least stage 2 of Norwood-Hamilton classification. Premature AGA not only adds to psychological stress but is also reported as a risk factor for cardiovascular diseases, metabolic syndrome and carcinoma prostrate. In many subsequent studies, AGA has been shown to be associated with several diseases such as insulin resistance (IR), abnormal serum lipid profiles and obesity. Methods: Various parameters of metabolic syndrome were measured in 75 male patients of AGA in the department of dermatology, Safdarjung hospital from June 2015 to April 2016. ECG and echocardiography was done in all patients to look for any evidence of premature coronary artery disease . Results: In our ...