Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population (original) (raw)
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Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population
Journal of Life Sciences, 2017
Helicobacter pylori (H. pylori) colonize the gastric mucosa of 50% of the world's population. This infection is closely associated with the development of peptic ulcer disease and gastric cancer. The present study was conducted to assess the prevalence of H. pylori infection in Moroccan population and the risk to develop gastric precancerous lesions and gastric cancer. Totally, 298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with gastric diseases. Histological examination was effected to diagnostic gastric lesions and to detect H. pylori. ELISA was used to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic subjects was observed higher. A significant relationship was detected between H. pylori infection and the risk of gastric diseases (p-value < 0.0001). A meaningful association between chronic gastritis increasing and age was observed (p-value = 0.03). The risk to develop gastric cancer among infected patients was observed elevated with rate of 9%. Our results showed a high prevalence of H. pylori in both asymptomatic and gastric diseases patients. We noticed that chronic gastric infection increases with age. We remarked also that the risk to develop gastric cancer among infected patients was elevated in our population.
Incidence of helicobacter pylori infection and gastric cancer : an 8-year hospital based study
Acta medica Indonesiana
To observe the tendency of decreased prevalence of H pylori infection in a 14 year-period and observe the prevalence of intestinal metaplasia and gastric cancer. All patients who were diagnosed with dyspepsia and underwent esophagogastroduodenoscopy in Cikini hospital Jakarta from January 1998 until December 2005 were evaluated. We evaluated the histopathologic result of H pylori, the presence of intestinal metaplasia and gastric cancer. Data was grouped for 1 year period of time and was presented descriptively. Decreased prevalence of H. Pylori infection was found, from 12.8% in 1998, 12.4% in 1999, 14.7% in 2000, 9.6% in 2001, 11.9 % in 2002, 3.8% in 2003, 2.3% in 2004, 2.9% in 2005. Intestinal metaplasia was 4.7% in 1998, 3.2% in 1999, 3.1% in 2000, 2.3 % in 2001, 7.6% in 2002, 8.3% in year 2003, 6.5% in 2004, 7.1% in 2005. Prevalence of gastric cancer was 2.2% in 1998, 0.25% in 1999, 1.1% in 2000, 1.1% in 2001, 1.1% in 2002, 1.8% in 2003, 1.7% in 2004, 3.9% in 2005. There was de...
Journal of gastroenterology, 1997
We conducted a case-control study to examine the association of Helicobacter pylori infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies for Helicobacter pylori were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent of Helicobacter pylori-associated gastritis. The seroprevalence of Helicobacter pylori in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P < 0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69-5.33) and those with a precancerous condition (odds rati...
Saudi Journal of Pathology and Microbiology, 2021
Background: Helicobacter pylori infection of the gastric mucosa is the most important aetiologic agent identified to cause chronic gastritis with consequences ranging from acute ulceration to the development of debilitating gastric cancer. Histopathologic characterisation of the disease progression from gastric biopsies is frequently required. Objectives: To determine the histopathologic pattern of gastric biopsies categorised chronic gastritis using updated Sydney classification and determined the role of Helicobacter pylori in chronic gastritis in our centre. Methodology: A retrospective study of all the gastric biopsies received in the department of Histopathology, Usmanu Danfodio University Teaching Hospital, and Sokoto between the years 2011-2020. Formalin fixed, paraffin embedded tissue blocks and slides stained with routine, special and immunohistochemical stains were used. Microscopic features detailing different pathologies were analysed and chronic gastritis were classified based on updated Sydney classification. Information on age, sex and duration of disease was retrieved from request cards and case folders. Collected data analyzed using SPSS version 20. Results: There were 252 gastric biopsies received, 137 male and 115 female patients and a ratio of 1.2:1. Their ages ranged from 16 to 82 years and peak in the 6 th decade of life with a mean age of 46.5 years. The most common diagnosis was chronic gastritis and constitutes 85.5% (215 cases), followed by adenocarcinoma (10.3%), gastrointestinal stromal tumour (2.4%) and gastric ulcer (2.0%). Among chronic gastritis, 47.4% were H. pylori associated. Moderate to severe activity and inflammation were seen in 45.6% and 48.4% respectively. Mucosal atrophy (Atrophic Gastritis) was seen 81.4% while 19.5% show complete or incomplete intestinal metaplasia. Conclusion: Helicobacter pylori organism was the common cause of gastric morbidity in our environment, causing chronic gastritis with predominantly mild to moderate grade of inflammation, mucosal atrophy, activity and organisms colonisation.
Incidence of gastric cancer, its subtypes, and correlation with Helicobacter Pylori
Journal of Pathology of Nepal, 2013
Background: Gastric cancer is the fourth most commonly diagnosed cancer and the second most common cause of cancer related death worldwide. It is the common cause of cancer related death in Nepal. Helicobacter Pylori has been classified as a definite carcinogen along with other factors. The aim of this study was to fi nd the incidence of gastric cancer among the patients undergoing upper gastroscopy, its various subtypes and association with Helicobacter Pylori. Materials and Methods: This is a retrospective and prospective study carried out at GRP Polyclinic and Kist Medical College Teaching Hospital. All the patients undergoing upper gastrointestinal endoscopy were included in this study. Data of all the gastric endoscopic biopsies done from June 2011 to January 2013 were collected and analyzed. All the biopsy specimens were processed routinely in histopathology laboratory. Specimens showing carcinoma were enrolled in this study and all the relevant demographic data were collected...
Pan African Medical Journal, 2015
Introduction: the study aimed at determining the different types of precancerous conditions of the stomach and searches the frequency of Helicobacter pylori in these lesions in patients with chronic antral gastritis in Yaounde, Cameroon. Methods: five gastric biopsies were performed during upper gastrointestinal endoscopy for pathology and fixed in formol 10% before being coated in paraffin. Both the modified Giemsa and Periodic acid of Shift-Alkaline blue stains were used for the histological diagnosis of Helicobacter pylori infection. Hematoxylyn and eosin stain was used to determine the activity of gastritis, atrophic gastritis and intestinal metaplasia in accordance to the Sydney's classification of gastritis. Data were analysed using both the Epi info 6.04 and Excel 2007 softwares. Means and their standard deviations, medians and their interquartiles (IQR) were calculated. Proportions were established for qualitative variables and chi square analysis done in this study with a p value set at 0.05. Results: seventy-nine patients with chronic antral gastritis were enrolled, of which 43 (54.4%) were male, median age: 43 years (range from 21 to 70 years). The rate of atrophic gastritis was 74.7% (59/79). The activity of atrophic gastritis was mild in 47.5% (28/59) of cases, moderate in 47.5% (28/59) and severe in 5% (5/59). Intestinal metaplasia and follicular gastritis were present in 6.3% (5/79), and 10.1% (8/79), respectively. Concerning Helicobacter pylori infection, 71.2% (42/59) of patients with atrophic gastritis tested positive against 28.8% (17/59) who tested negative (p = 0.00003). Helicobacter pylori infection was related to the severity of gastric atrophy (p = 0.0001). Among patients with intestinal metaplasia and follicular gastritis, the proportion of those who tested positive for Helicobacter pylori infection was 80% (4/5), and 75% (6/8), respectively. There were no significant differences in the occurrence of atrophic gastritis according to age groups (p = 0.908). Conclusion: this study concludes that atrophic gastritis, which is most often caused byHelicobacter pylori, is the most frequent precancerous condition of stomach in Cameroon. Routine gastric sampling for pathologic analysis is mandatory for effective diagnosis and surveillance of Helicobacter pylori infection and precancerous conditions of the stomach.
Clinicopathological Study of Gastric Carcinoma with Special Reference to Helicobacter pylori
Journal of Pure and Applied Microbiology
Gastric cancer (GC) is one of the most common malignancies. Although Helicobacter pylori (H. pylori) is being recognized as a Type I carcinogen for GC and primary gastric lymphoma (PGL), yet many studies especially from the Indian subcontinent do not show any such association. The aim of the study was to evaluate the clinicopathological characteristics of gastric adenocarcinoma and to determine the association of H. pylori infection. This prospective study included 50 cases of histologically proven gastric adenocarcinoma. A detailed clinical history, physical examination and upper gastrointestinal endoscopy were done in all the cases and mucosal biopsies were taken from the growth and the surrounding mucosa. Rapid urease test (RUT) was done to diagnose H. pylori infection. 50 patients of functional dyspepsia were taken as controls. GC was more common in males (70%). The maximum cases were recorded in elderly persons, mostly from 5 th to 6 th decades. Anorexia (60%), dyspepsia (54%) and weight loss (24%) were the commonest clinical presentation. Most of the patients presented within 3-12 month of onset of symptom. In majority of cases, the lesion was confined to the antrum (62%) and body (26%) of the stomach. H. pylori infection was more commonly isolated from the antrum. H. pylori infection was not significantly associated with GC as compared to patients with functional dyspepsia. No association was found between H. pylori infection and gastric carcinoma. Probably gastric cancer is multifactorial disease where dietary, genetic and environmental factors play contributing roles.
Association of Helicobacter Pylori Infection and Gastric Cancer
Post-Graduate Medical Journal of NAMS, 2015
Introduction: Gastric cancer remains one of the most common cancers worldwide and the second leading cause of cancer mortality in the world. Helicobacter Pylori is a major risk factor. Early detection of infection and eradication therapy will probably reduce the incidence of stomach cancer. This study is carried out to see the association of the H. pylori infection in gastric cancer patients in our population. Methods: This is a prospective cross sectional descriptive study done in Gastroenterology unit, Department of medicine, National Academy of Medical Sciences, Bir Hospital. Patients who were suspected of cancer of stomach clinically as well as endoscopically,their thorough history was taken and demographic profiles like age, sex and geographic location were recorded. Similarly, symptoms, risk factors and endoscopic finding were recorded. Likewise, result of rapid urease test and histopathology results were documented. Results: Male patients were seen to be more frequently affec...