Chemical Characterization of Indian Smokeless tobacco products by spectroscopy, chromatography, and allied techniques: Interproduct Variation (original) (raw)

Abstract

Background: This investigation provides an updated study measuring the levels of chemical components for the top-selling smokeless tobacco products (SLT) viz. khaini, mishri, pan masala + tobacco, snus, and tobacco-betel nut mixture in the Indian market. Methods:A total of twelve SLT were collected and analyzed for nitrosamines and polycyclic aromatic hydrocarbons using various standard techniques of gas and liquid chromatography(as GC-MS, GC-TEA, LC-MS/MS)at two different laboratories and compared to previous studies. Results: Mishri contains a major share of tobacco-specific nitrosaminesas NNN (10 folds where folds refer to a comparison of average) and NNK (25-30 folds) with higher ratio than other SLT. Total polycyclic aromatic hydrocarbons content of mishri quantified to be 702-794 µg/g of SLT which was 7-9 fold higher than snus. On geographical distribution, SLT composition reflects inter and intra-differences. TSNA levels were drastically different between mishri and khaini sa...

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