Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles (original) (raw)

Polymer-block-peptide conjugates are tailored to render hydrophobic small molecule drugs water soluble. The combinatorial strategy selects for bioconjugates that exhibit sequencespecific solubilization and switchable release profiles of the cargo through incorporation of a disulfide linker moiety into the peptide-library design. While the study focused on the photosensitizer m-THPC and reductive carrier cleavage, the approach is generic and might be expanded toward a broad range of poorly soluble smallmolecule drugs and other selective cleavage mechanisms to disassemble a peptide binding domain of the bioconjugatebased solubilizer.