Transfer learning for cancer diagnosis in histopathological images (original) (raw)
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Classification of Breast Cancer Histopathological Images Using DenseNet and Transfer Learning
Computational Intelligence and Neuroscience, 2022
Breast cancer is one of the most common invading cancers in women. Analyzing breast cancer is nontrivial and may lead to disagreements among experts. Although deep learning methods achieved an excellent performance in classification tasks including breast cancer histopathological images, the existing state-of-the-art methods are computationally expensive and may overfit due to extracting features from in-distribution images. In this paper, our contribution is mainly twofold. First, we perform a short survey on deep-learning-based models for classifying histopathological images to investigate the most popular and optimized training-testing ratios. Our findings reveal that the most popular training-testing ratio for histopathological image classification is 70%: 30%, whereas the best performance (e.g., accuracy) is achieved by using the training-testing ratio of 80%: 20% on an identical dataset. Second, we propose a method named DenTnet to classify breast cancer histopathological images chiefly. DenTnet utilizes the principle of transfer learning to solve the problem of extracting features from the same distribution using DenseNet as a backbone model. *e proposed DenTnet method is shown to be superior in comparison to a number of leading deep learning methods in terms of detection accuracy (up to 99.28% on BreaKHis dataset deeming training-testing ratio of 80%: 20%) with good generalization ability and computational speed. *e limitation of existing methods including the requirement of high computation and utilization of the same feature distribution is mitigated by dint of the DenTnet.
International Journal of Electrical and Computer Engineering (IJECE), 2024
Convolutional neural networks (CNN) which are deep learning-based methods are being currently successfully deployed and have gained much popularity in medical image analysis. CNN can handle enormous amounts of medical data which makes it possible for accurate detection and classification of breast cancer from histopathological images. In the proposed method, we have implemented transfer learning-based classification of breast cancer histopathological images using DenseNet121, DenseNet201, VGG16, VGG19, InceptionV3, and MobileNetV2 and made a performance analysis of the different models on the publicly available dataset of BreakHis. These networks were pre-trained on the ImageNet database and initialized with weights which are fine-tuned by training with input histopathological images. These models are trained with images of the BreakHis dataset with multiple image magnifications. From the comparative study of these pretrained models on histopathology images, it is inferred that DenseNet121 achieves the highest breast cancer classification accuracy of 0.965 compared to other models and contemporary methods.
Transfer learning based histopathologic image classification for breast cancer detection
Health Information Science and Systems, 2018
Breast cancer is one of the leading cancer type among women in worldwide. Many breast cancer patients die every year due to the late diagnosis and treatment. Thus, in recent years, early breast cancer detection systems based on patient's imagery are in demand. Deep learning attracts many researchers recently and many computer vision applications have come out in various environments. Convolutional neural network (CNN) which is known as deep learning architecture, has achieved impressive results in many applications. CNNs generally suffer from tuning a huge number of parameters which bring a great amount of complexity to the system. In addition, the initialization of the weights of the CNN is another handicap that needs to be handle carefully. In this paper, transfer learning and deep feature extraction methods are used which adapt a pre-trained CNN model to the problem at hand. AlexNet and Vgg16 models are considered in the presented work for feature extraction and AlexNet is used for further fine-tuning. The obtained features are then classified by support vector machines (SVM). Extensive experiments on a publicly available histopathologic breast cancer dataset are carried out and the accuracy scores are calculated for performance evaluation. The evaluation results show that the transfer learning produced better result than deep feature extraction and SVM classification.
Classification of Breast Cancer Histology Images Using Transfer Learning
Image Analysis and Recognition, 2018
Breast cancer is one of the leading causes of mortality in women. Early detection and treatment are imperative for improving survival rates, which have steadily increased in recent years as a result of more sophisticated computer-aided-diagnosis (CAD) systems. A critical component of breast cancer diagnosis relies on histopathology, a laborious and highly subjective process. Consequently, CAD systems are essential to reduce inter-rater variability and supplement the analyses conducted by specialists. In this paper, a transfer-learning based approach is proposed, for the task of breast histology image classification into four tissue sub-types, namely, normal, benign, in situ carcinoma and invasive carcinoma. The histology images, provided as part of the BACH 2018 grand challenge, were first normalized to correct for color variations resulting from inconsistencies during slide preparation. Subsequently, image patches were extracted and used to fine-tune Google's Inception-V3 and ResNet50 convolutional neural networks (CNNs), both pre-trained on the ImageNet database, enabling them to learn domain-specific features, necessary to classify the histology images. The ResNet50 network (based on residual learning) achieved a test classification accuracy of 97.50% for four classes, outperforming the Inception-V3 network which achieved an accuracy of 91.25%.
Transfer Learning in Brain Tumor Detection: from AlexNet to Hyb-DCNN-ResNet
Highlights in Science, Engineering and Technology
Detecting abnormalities in the human body with magnetic resonance imaging has long been a challenge in medical computer-aided diagnosis (CAD). This paper presents a comprehensive review of research focusing on transfer learning (TL) in brain tumor detection. Each work starts from collecting MR images and substantial strategies are applied when preprocessing data including data augmentation and image segmentation. Multiple pre-trained models from AlexNet to Hyb-DCNN-ResNet in the latest work are focused. And the results of binary and multiple class classification are compared chronologically. Three pre-trained models which are frequently used to attain a good performance in brain tumor detection are illustrated in detail. And these pre-trained models, GoogLeNet, VGG and ResNet, all are capable to help the proposed systems reach the accuracy of 99%. The challenges even after transferring apposite knowledge to the target domain still exist in pluralistic forms. But the essence of trans...
IEEE Access
Cancer accounts for a huge mortality rate due to its aggressiveness, colossal potential of metastasis, and heterogeneity (causing resistance against chemotherapy). Lung and colon cancers are among the most prevalent types of cancer around the globe that can occur in both males and females. Early and accurate diagnosis of these cancers can substantially improve the quality of treatment as well as the survival rate of cancer patients. We propose a highly accurate and computationally efficient model for the swift and accurate diagnosis of lung and colon cancers as an alternative to current cancer detection methods. In this study, a large dataset of lung and colon histopathology images was employed for training and the validation process. The dataset is comprised of 25000 histopathology images of lung and colon tissues equally divided into 5 classes. A pretrained neural network (AlexNet) was tuned by modifying the four of its layers before training it on the dataset. Initial classification results were promising for all classes of images except for one class with an overall accuracy of 89%. To improve the overall accuracy and keep the model computationally efficient, instead of implementing image enhancement techniques on the entire dataset, the quality of images of the underperforming class was improved by applying a contrast enhancement technique which is fairly simple and efficient. The implementation of the proposed methodology has not only improved the overall accuracy from 89% to 98.4% but has also proved computationally efficient.
ResNet50-Based Effective Model for Breast Cancer Classification Using Histopathology Images
Computer Modeling in Engineering & Sciences
Breast cancer is considered an immense threat and one of the leading causes of mortality in females. It is curable only when detected at an early stage. A standard cancer diagnosis approach involves detection of cancer-related anomalies in tumour histopathology images. Detection depends on the accurate identification of the landmarks in the visual artefacts present in the slide images. Researchers are continuously striving to develop automatic machine-learning algorithms for processing medical images to assist in tumour detection. Nowadays, computerbased automated systems play an important role in cancer image analysis and help healthcare experts make rapid and correct inferences about the type of cancer. This study proposes an effective convolutional neural networkbased (CNN-based) model that exploits the transfer-learning technique for automatic image classification between malignant and benign tumour, using histopathology images. Resnet50 architecture has been trained on new dataset for feature extraction, and fully connected layers have been fine-tuned for achieving highest training, validation and test accuracies. The result illustrated state-of-the-art performance of the proposed model with highest training, validation and test accuracies as 99.70%, 99.24% and 99.24%, respectively. Classification accuracy is increased by 0.66% and 0.2% when compared with similar recent studies on training and test data results. Average precision and F1 score have also improved, and receiver operating characteristic (RoC) area has been achieved to 99.1%. Thus, a reliable, accurate and consistent CNN model based on pre-built Resnet50 architecture has been developed.
Transfer Learning using Alexnet with Support Vector Machine for Breast Cancer Detection
2020
Breast cancer is one of the leading causes of women death worldwide currently. Developing a computer-aided diagnosis system for breast cancer detection became an interesting problem for many researchers in recent years. Researchers focused on deep learning techniques for classification problems, including Convolutional Neural Networks (CNNs), which achieved great success. CNN is a particular type of deep, feedforward network that has gained attention from the research community and achieved great successes, especially in biomedical image processing. In this paper, transfer learning and deep feature extraction methods are used which adapt a pre-trained CNN model to classify breast cancer histopathological images from the publically available (BreakHis dataset). The data set includes both benign and malignant images with four different magnification factors. A patch strategy method proposed based on the extraction of image patches for training the CNN and the combination of these patc...
MATRIK : Jurnal Manajemen, Teknik Informatika dan Rekayasa Komputer
cancer caused 2.3 million cases and 685,000 deaths in 2020. Histopathology analysis is one of the tests used to determine a patient’s prognosis. However, histopathology analysis is a time-consuming and stressful process. With advances in deep learning methods, computer vision science can be used to detect cancer in medical images, which is expected to improve the accuracy of prognosis. This study aimed to apply Convolutional Neural Network (CNN) and Transfer Learning methods to classify breast cancer histopathology images to diagnose breast tumors. This method used CNN, Transfer Learning ((Visual Geometry Group (VGG16), and Residual Network (ResNet50)). These models undergo data augmentation and balancing techniques applied to undersampling techniques. The dataset used for this study was ”The BreakHis Database of microscopic biopsy images of breast tumors (benign and malignant),” with 1693 data classified into two categories: Benign and Malignant. The results of this study were base...
Cornell University - arXiv, 2022
Distinguishing normal from malignant and determining the tumor type are critical components of brain tumor diagnosis. Two different kinds of dataset are investigated using state-of-the-art CNN models in this research work. One dataset(binary) has images of normal and tumor types, while another(multi-class) provides all images of tumors classified as glioma, meningioma, or pituitary. The experiments were conducted in these dataset with transfer learning from pre-trained weights from ImageNet as well as initializing the weights randomly. The experimental environment is equivalent for all models in this study in order to make a fair comparison. For both of the dataset, the validation set are same for all the models where train data is 60% while the rest is 40% for validation. With the proposed techniques in this research, the EfficientNet-B5 architecture outperforms all the state-of-the-art models in the binaryclassification dataset with the accuracy of 99.75% and 98.61% accuracy for the multi-class dataset. This research also demonstrates the behaviour of convergence of validation loss in different weight initialization techniques.