The Valorization of Agro-Wastes and Stevia Leaves as a Sugar Replacer in Cupcake Formulas: Histological and In Vivo Studies on Diabetic Rats (original) (raw)
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Bulletin of the National Nutrition Institute of the Arab Republic of Egypt
he effect of using food products fortified with stevia leaves and other materials such as pomegranate molasses, ginger, sesame seeds, and pumpkin seeds on the general acceptability of the sweetness and its ameliorative impacts on diabetes caused by STZ in rats. The sweets were prepared as (control and supplemented with stevia leaves individually and in combination with the other materials). The proximate chemical composition of raw materials, products, and sensory properties were evaluated. The results revealed that STZ induced diabetes in rats caused a significant decrease in FBW, BWG%, G%, FI and FER compared to the negative control group. While, found a increase in ALT and AST, TC, TG, VLDL-C, and LDL-C, however, serum HDL-C level, testosterone, LH and FSH, SOD, activity and GPA and NO were decreased significantly compared to the healthy rats. Administration of stevia with other materials such as pomegranate molasses, ginger, sesame seeds, and pumpkin seeds alleviates the impact of diabetic disease. The conclusion was that sweetness products supplemented with stevia received acceptable sensory scores and exhibited protection in diabetes. This effect can be attributed to their high nutritional quality and their rich content of the antioxidant activity, and minerals especially phosphorus, calcium, sodium, zinc, copper, iron, and magnesium.
Effect of Diet Supplementation with Food Industry By-Products on Diabetic Rats
Food and Nutrition Sciences
The present research work aimed to study the effects of 3 nutritional food industry by-products (orange peels, peanut skin peels and pomegranate peel) on regulating blood glucose level. 66 male adult Sprague-Dawely rats weighing 125 ± 5 g each were used. These rats were injected with alloxan for inducing diabetes. The negative control group consisted of rats fed on basal diet, while the positive control group consisted of (3 -11) sub-groups fed on basal diet in addition to 5%, 7.5% and 10% of nutritional food industry by-products. After 4 weeks the effect of the different experimental diets on body weight gain, organs relative weight, blood glucose level, liver functions and kidney functions was recorded for the negative group and all the positive sub-groups. The results revealed that there was non-significant difference between all relative organ weights of liver, kidney and pancreas compared to control negative. Blood glucose level significantly decreased in all sub-groups compared to the control positive group.
2020
The purpose of current study was to enhance the nutritional value of cakes by substituting wheat flour by pumpkin fruit and its seeds as a source of protein, phenolics and flavonoids. Cakes were made by substituting wheat flour with a constant percentage of fresh pumpkin fruit (10% as dry weight) or replacement wheat flour with fresh pumpkin fruit using the same previous percentage and different levels of whole pumpkin seeds (10, 20, 30 and 40%). The different kinds of cakes were subjected for nutritional and sensory evaluation. Effect of feeding with cakes enhanced with pumpkin fruit and its seeds on serum biochemical analysis and histological examination of pancreas for alloxan-induced diabetic male rats after three months treatment was also assessed. Results estimated that cakes containing both fresh pumpkin fruit and whole pumpkin seeds showed significantly increased (P<0.05) in protein, fiber, ash, phenolics and flavonoids as well as this increase was associated with the lev...
Effect of artificial and natural sweeteners onglucose and insulin in plasma of rats
Effect of artificial and natural sweeteners on glucose and insulin in plasma of rats. J Pre-Clin Clin Res. Abstract Introduction: The role of artificial sweeteners in body-weight regulation is still unclear. Replacing sugar with low-calorie sweeteners is a common strategy for facilitating weight control. Whether using artificial sweeteners may augment positive energy balance through increased food intake was investigated. The effects of sweet taste and its sources (carbohydrate and non-caloric sweeteners) on diet growth efficiency, fasting and postprandial glucose and insulin plasma concentrations were also compared. Material and method: 140 male Sprague-Dawley rats (initial body mass: 325 ± 19g) were randomly divided into 4 groups. Each group was provided with isoenergetic diets: 3 with the same sweet taste intensity (with sucralose – SU, sucrose – SC and maltodextrine – M) and one diet non-sweet (NS). Food intake was recorded daily and body weight measured twice a week/controlled ...
Stevia Derivative and its Potential Uses in Diabetic-Directed Foods. Review
Journal of Nutrients, 2016
Diabetes has been contextualized as pandemic, but market supplying their food does not seem to grow in parallel with the problem. There are many substances on the market that will be useful as ingredients to produce foods for diabetic consumers, focusing on the sweeteners, which can be used for food processing with low calories, and low glycemic index. Natural or synthetic sweeteners have received renewed attention with the toxicological acceptance and commercial development. However, many of them have little prospect of becoming commercial ingredients because, they do not meet some of the key criteria for commercial success. The stevia plant and its products have potential for commercial uses as sweetener or therapeutic. Beside the two known main molecules that are intense sweeteners that are occurring in stevia (stevioside and rebaudioside A), the plant contain other compounds of nutritional importance for therapeutic uses. The acceptable daily intake or ADI of 4 mg/kg bw/day to steviol glycosides have been regulated to glycosides of stevia. Moreover, there exists production of stevia worldwide, with established procedures for isolation and purification of its glycosides and one of them has been approved for food use. Then, a solid market of diabetes-oriented products must emerge, for satisfying demands from these consumers.
The anti-diabetic activities of natural sweetener plant Stevia: an updated review
SN applied sciences, 2021
Diabetes mellitus is one of the key metabolic diseases cause due to defects in the secretion of insulin, insulin resistance in peripheral tissues, or both. Plants remained an important source of nutrition as well as medicine. Stevia rebaudiana Bertoni is one of the important high qualities non-caloric sugar substitute sweetener plants against diabetes disease. The compounds like steviol, rebaudioside A, stevioside, etc. can lower the sugar level many fold. In addition, it decreases oxidative stress, hence reduces the risk of diabetes. Its leaves have been used for the control and treatment of diabetes and many other metabolic diseases. In animal model experiments it reduces blood sugar level and promotes liver and kidney functions. In this review, we highlighted the most recent literature on the safe use of Stevia for the treatment of diabetes, its use as a functional food, and its mode of therapeutic action in different animal model experiments. However, keeping Stevia as a model plant; detailed investigations are needed for the identification of new metabolites and its use against diabetes and related diseases.
STUDIES ON ETHNO-MEDICINE, 2009
During present investigation medicinal uses of these shell fishes has been studied. It was found that after removal of shell and mantle of Pila, Bellamya, Lamellidens and Parreysia, the flesh of these molluscs in various forms consumed for the cure of some aliments of local people and also provide essential animal proteins, steroids, vitamins and minerals to the people of the region. The flesh of Pila and Viviparous sp. is used as medicine to cure asthma, swelling of joints, burns by aboriginal people of this region. The foot portion of these edible shell fishes is eaten in the form of curry as well as in roasted form at regular intervals. The soup of eggs of these species are also used as medicine and given to children suffering from rickets. The flesh of Lamellidens, is eaten in the form of cooked curry and given to people suffering from cardiac diseases and blood pressure. It was also observed that the local people of the region consumed these shell fishes to cure a number of other ailments such as rheumatism, calcium metabolism, heart diseases, conjunctivitis, giddiness, nervousness, dehydration and various gastro intestinal disorders.
Bangladesh Journal of Veterinary Medicine, 2009
Now a day, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its efficacy study with a patent drug, Glimepiride. The effects of powdered form of Stevia leaves was evaluated in the Streptozotocin (STZ; 55 mg/kg body weight as single intraperitoneal injection) induced diabetic rats and for this, powdered form of Stevia leaves was orally administered at three different dose rates of 150 mg/kg, 200 mg/Kg and 250 mg/Kg body weight, respectively once a day for 3 weeks. Changes in the blood glucose levels and body weights were measured and the data obtained were compared with that of Glimepiride statistically by using Student's unpaired t-test. The powdered form of Stevia leaves produced significant (p<0.01 or p<0.05) hypoglycemic effects on Streptozotocin induced diabetic rats in comparison with that of the standard drug, Glimepiride. Powdered form of Stevia leaves at a dose rate of 250 mg/Kg decreased body weight significantly (p<0.01 or p<0.05) in STZ-induced diabetic rats. From this study, it was observed that powdered form of Stevia leaves possessed both hypoglycemic and body weight reducing effects.
Bangladesh Journal of Veterinary Medicine, 2009
Now a day, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its efficacy study with a patent drug, Glimepiride. The effects of powdered form of Stevia leaves was evaluated in the Streptozotocin (STZ; 55 mg/kg body weight as single intraperitoneal injection) induced diabetic rats and for this, powdered form of Stevia leaves was orally administered at three different dose rates of 150 mg/kg, 200 mg/Kg and 250 mg/Kg body weight, respectively once a day for 3 weeks. Changes in the blood glucose levels and body weights were measured and the data obtained were compared with that of Glimepiride statistically by using Student's unpaired t-test. The powdered form of Stevia leaves produced significant (p<0.01 or p<0.05) hypoglycemic effects on Streptozotocin induced diabetic rats in comparison with that of the standard drug, Glimepiride. Powdered form of Stevia leaves at a dose rate of 250 mg/Kg decreased body weight significantly (p<0.01 or p<0.05) in STZ-induced diabetic rats. From this study, it was observed that powdered form of Stevia leaves possessed both hypoglycemic and body weight reducing effects.