Pharmacokinetics of florfenicol following intramuscular and intravenous administration in olive flounder (Paralichthys olivaceus) (original) (raw)

2010, Journal of Veterinary Pharmacology and Therapeutics

Florfenicol, a fluorinated derivative of thiamphenicol, is a broadspectrum antibiotic used in veterinary medicine belonging to the family of agents that includes chloramphenicol and thiamphenicol (Graham et al., 1988; Cannon et al., 1990). Florfenicol is effective against most fish-pathogenic bacteria including Photobacterium damsela (subsp. Piscicida), Vibrio anguillarum, Aeromonas hydrophila, Aeromonas salmonicida, Edwardsiella ictalur, and Edwardsiella tarda (McGinnis et al., 2003). These common pathogens causing the most economically serious diseases in olive flounder are Edwardsiella tarda, Flexibacter maritimus, Vibrio spp. (V. anguillarum, V. ichthyoenteri), and streptococcus spp. (S. iniae, S. parauberis, Lactococcus garvieae) as similar in other marine fish species (NFRDI, 2006). Florfenicol has been demonstrated to be effective in the treatment of various fish diseases in yellowtail fish (Yasunaga & Yasumoto, 1988), channel catfish (McGinnis et al., 2003), goldfish (Fukui et al., 1987), and Atlantic salmon (Inglis et al., 1991). Because florfenicol has been proven to be clinically effective in controlling fish pathogens in fish, it has been approved for use in Europe, Norway, Canada, Japan, China, and South Korea for a variety of fish species (Gaunt et al., 2003) Its pharmacokinetic profile have also been described for