The influence of bicarbonate supplementation on plasma levels of branched-chain amino acids in haemodialysis patients with metabolic acidosis (original) (raw)

is characterized by a reduction in muscle mass [4 ]. However, even in patients without clinical signs of Background. It has been hypothesized that correction of metabolic acidosis might improve the nutritional protein-calorie malnutrition, abnormalities of aminoacid metabolism may already be present. For example, state of acidotic haemodialysis (HD) patients partly because of a reduced oxidation of branched-chain reduced extra-and intracellular levels of several essential amino acids have been observed in haemodialysis amino acids (BCAA). Aim. We investigated whether bicarbonate (Bic) patients [5,6]. Especially the altered metabolism of branched-chain amino acids, which are important pre-supplementation in acidotic HD patients results in increased plasma levels of BCAA.