Influence of uremia and hemodialysis on circulating interleukin-1 and tumor necrosis factor (original) (raw)

1990, Kidney International

AI-generated Abstract

This study investigates the influence of uremia and hemodialysis (HD) on the circulating levels of interleukin-1 (IL-1) and tumor necrosis factor (TNFα) in patients undergoing HD. It evaluates the effect of different dialysis membranes, specifically cellulosic and synthetic options, on the release of these pro-inflammatory cytokines in both first-dialysis uremic patients and long-term HD patients. Results demonstrate a significant elevation of IL-1 in long-term HD patients, with no significant change in TNFα levels during dialysis, indicating the complex interaction between uremia, dialysis methods, and inflammatory responses.