Identification of a pyridine derivative of diselenides as a potent inhibitor of the main protease of SARS-CoV-2 through in silico screening and biochemical evaluation (original) (raw)

Identification of a pyridine derivative of diselenides as a potent inhibitor of the main protease of SARS-CoV-2 through in silico screening and biochemical evaluation

New Journal of Chemistry

Abstract

Among the 22 organoselenium compounds studied, 2-Py2Se2 & Nict2Se2 showed the highest affinity for Mpro. The biochemical studies confirmed their superiority as compared to standard compound like Ebselen in terms of the IC50 required for Mpro inhibition.

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