Tie1 controls angiopoietin function in vascular remodeling and inflammation (original) (raw)
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
Donald McDonald
The Journal of clinical investigation, 2016
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Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
Urban Deutsch
The FASEB Journal, 2007
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Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands
Scott Henderson
Molecular cell, 2010
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Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
Gyun Lee
Journal of Cell Biology, 2005
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Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
Vicky PKH Nguyen
Journal of Cell Science, 2006
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Functional Significance of Tie2 Signaling in the Adult Vasculature
Liwen Huang
2010
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The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
Yvonne Reiss
Journal of Cell Science, 2005
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Activation of the Tie2 Receptor by Angiopoietin-1 Enhances Tumor Vessel Maturation and Impairs Squamous Cell Carcinoma Growth
Paula Andrea Gómez Velasco
The American Journal of Pathology, 2002
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Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses
Miikka Vikkula
Journal of Cell Science, 2012
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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Yvonne Kienast
Journal of Clinical Investigation, 2012
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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts In Vivo Angiogenesis
Stanley C Atueyi
Science, 1997
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Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems
P. Saharinen
Clinical science (London, England : 1979), 2017
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Angiopoietin-1 and Its Receptor Tie2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells
lu li
Microvascular Research, 1999
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Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2
Bernhard Witzenbichler
Journal of Biological Chemistry, 1998
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VEGF Induces Tie2 Shedding via a Phosphoinositide 3Kinase/Akt-Dependent Pathway to Modulate Tie2 Signaling
Asif Ahmed
2010
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Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
David Entenberg
Cancers
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Tie2 Receptor Expression Is Stimulated by Hypoxia and Proinflammatory Cytokines in Human Endothelial Cells
Carsten Willam
Circulation Research, 2000
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Stable interaction between alpha5 beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
Guido Serini
The Journal of Cell Biology, 2005
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Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
Federico Bussolino
Journal of Cell Biology, 2005
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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
Donald McDonald
Proceedings of the National Academy of Sciences, 2006
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Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development
Marika Korhonen
Arteriosclerosis Thrombosis and Vascular Biology, 2010
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Inhibition of Tumor Angiogenesis Using a Soluble Receptor Establishes a Role for Tie2 In Pathologic Vascular Growth
Pedro Lin
Journal of Clinical …, 1997
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Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses
Judith Favier
Blood, 2005
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Endothelial destabilization by angiopoietin-2 via integrin β1 activation
Tuomas Sipilä
Nature Communications, 2015
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Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis
Rifqi Najwan
Journal of Clinical Investigation, 2018
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Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap
Svetlana R Amirova
Scientific reports, 2017
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Oligomerization and Multimerization Are Critical for Angiopoietin-1 to Bind and Phosphorylate Tie2
Gyun Lee
Journal of Biological Chemistry, 2005
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Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development-Brief Report
P. Saharinen
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
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