The Use of Atypical Neuroleptics in Drugs Management in Fann’s Psychiatry Department (original) (raw)
Related papers
British Journal of Clinical Pharmacology, 2001
To describe the psychiatric indications of neuroleptics (especially the relative share of schizophrenic and other psychotic disorders) and the usage patterns of these drugs (dose, duration, coprescriptions). Methods A one-day national cross-sectional survey in a random sample of 723 French psychiatrists was carried out in 1996. Each psychiatrist was asked to complete a standardized questionnaire for the first three patients seen the day of the survey to whom at least one neuroleptic was prescribed (initiated or renewed). Results One thousand seven hundred and fifty-four questionnaires were returned. Three quarters of the patients (74%) were psychotic (664 with schizophrenia, and 636 other psychosis), 19.3% were depressive and 6.7% had other psychiatric disorders. Phenothiazines were the most often prescribed (40.8%), followed by butyrophenones (22.5%), benzamides (15.8%), other neuroleptics (14.8%) and thioxanthenes (6.1%). Among schizophrenic subjects, an average number of 1.54 (95% CI: 1.50-1.60) neuroleptics were prescribed per patient, compared with 1.4 (95% CI: 1.32-1.41) and 1.2 (95% CI: 1.14-1.23) in other psychotic and depressive subjects, respectively. Regardless of the indication, non-neuroleptic psychotropic drugs were coprescribed in 75.4%, mainly benzodiazepines (75.7%). Adjuvant drugs used in prevention or treatment of side-effects were coprescribed in 46.7%, mostly anticholinergic antiparkinsonians (86.1%). Conclusions Neuroleptics are mainly prescribed for psychotic disorders and especially schizophrenia. However, current recommendations are not always followed.
Pattern of Neuroleptic Drug Use in Italian Mental Health Services
DICP, 1991
The relationship between the prescribed daily dose of neuroleptic (NL) drugs and patient-, and drug-related characteristics was explored in a cross-sectional sample of 1141 patients treated in Italian mental health services. The results of a multiple linear regression showed that the prescribed daily dose was significantly lower in women, the elderly, and those with a shorter (one to six year) psychiatric history. In contrast, being an inpatient in psychiatric wards in general and public mental hospitals was significantly associated with a higher dose; marital status, education, and diagnosis were not. The number and potency (low to moderate vs. high) of the prescribed NLs were also significantly associated with the prescribed dose, and an interaction was found between the two. Implications of these findings for improvement in NL prescription patterns are discussed.
Neuroleptic dose: A statistical model for analyzing historical trends
Journal of Psychiatric Research, 1987
Neuroleptic dosing practices during inpatient treatment of schizophrenia were examined for 1490 admission episodes during 1973 through to 1982 in two wards of a university hospital. Chlorpromazine-eqnivalent dose levels (CPZE) declined 50070 between 1974 and 1980. As expected, length of treatment and choice of drug were both strongly related to CPZE. The general drop in CPZE is not explained by shorter treatment and changing choice of drug, however. Oral fluphenazine, haloperidol, and depot fluphenazine are used to higher maximum levels than chlorpromazine and other neuroleptics, when maximum dose is reached after one week or longer. The results illustrate that by seeking an appropriate statistical model, aggregate trends in dosing practices can be described while avoiding several of the shortcomings of earlier surveys of hospital practice.
Medical Science, 2017
Background There are a number of Psychotropic drugs available in the market for treatment of mental disorders currently. It is interesting to know the pattern of drug utilization among the psychotropic drugs and the degree of control of the psychiatric cases with the psychotropic drugs in the actual clinical set up in a tertiary health care centre. The main objective of the study was to find out the most common drug prescribed by the psychiatrist among the psychotropic drugs. Methods This is a cross sectional questionnaire based observational study was carried out at Manipal Teaching Hospital. It is a tertiary care hospital situated in the western development region of Nepal. Results Most of the patients were in between age group 14-40 years 77.6%. Majority of the patients were Brahmin 28.1%, Chettri 24%, Dalit 22.9%. About 79.2% of the patients were unemployed. Most of the patients were Hindu 84.4% followed by Buddhists 11.5%. The group of Psychotropic drugs most commonly prescribed were Neuroleptics 42.7% followed by Anxiolytics 16.1%, Antidepressants 15.1% Antimanics 9.4% as monotherapy and two or more psychotropic drugs combined 16.7%. Olanzapine was the most common drug prescribed followed by Haloperidol and Promethazine, Risperidone, Alprazolam, Sodium valproate, Clonazepam, Fluoxetine respectively. Conclusion Among the use of Psychotropic drugs there is a shift of treatment to Atypical Neuroleptics from Typical Neuroleptics may be due to absence of extrapydamidal and other major adverse effects of Typical Neuroleptics. The treatment of Depression the shift to SSRI from TCA has made the treatment more safe. Sodium valproate was found to be the commonest drug prescribed for the treatment of bipolar affective disorder, recommended that there is a trend of using newer drugs rather than the conventional mood stabilizers like Lithium for bipolar affective disorder.
Schizophrenia Bulletin, 2001
Converging evidence indicates that, in controlled drug trials, individuals receiving novel antipsychotlc medications have fewer adverse effects than those receiving conventional antlpsychotic medications. This in turn may lead to greater patient treatment satisfaction. This study examines patient satisfaction and burden of adverse effects in a county-wide epidemiologic study of first admission psychotic persons with psychosis who were receiving novel antipsychotic drugs (n = 42). Comparisons were made within this group, and between 25 of these persons and 25 others with the same diagnosis and sex, from the same epidemiologic study, who were receiving a comparable regimen of conventional antipsychotic drugs. Patients receiving novel antipsychotics were significantly more satisfied and were significantly less burdened by adverse effects than those receiving conventional antipsychotics. Among the group receiving novel antipsychotics, dosage was not related to satisfaction or burden of adverse effects. For those treated with risperidone (n = 27), there was a difference, approaching statistical significance, for greater satisfaction and less adverse effect burden among those persons with dosages less than 5 mg daily as compared to higher dosages.
[Analysis of prescription patterns of antipsychotic agents in psychiatry]
Actas españolas de psiquiatría
We describe the different diseases in which conventional and second generation antipsychotic (APS) prescriptions are made. Observational, retrospective, multicenter study based on the review of 300 clinical records of public and private sites, hospital and out-patient clinics, located in Salamanca, Vigo, Bilbao, Barcelona, Valencia, Oviedo and Malaga. The mean age of the population studied was 42 +/- 17 years; 56.6 % were men. Atypical drugs (67 %) were used basically versus classical ones (33 %). Classical APS are basically prescribed in bipolar disorder with/without psychotic symptoms (20.6 %), schizophrenia (18.3%) and delusional disorder (11.5 %). Atypical APS are fundamentally prescribed in schizophrenia (31.5 %), bipolar disorders with/without psychotic symptoms (12.5 %) and other psychotic disorders (8.9 %). When the psychotic disorders are considered by groups (schizophrenia, bipolar disorder with psychotic symptoms, delusional disorder and other psychotic disorders), classi...
Journal of Applied Pharmaceutical Science
Background: The association of mental disorder with cardiac disease is not a coincidence rather a strong relationship exists in between those two. Objective: We investigated the prescription pattern of psycholeptic drugs during the discharge of patients in a national cardiovascular hospital. Methods: Data was collected from the National Institute of Cardiovascular Diseases (NICVD) at Dhaka in Bangladesh. In total, 1076 prescriptions were collected randomly from July 2012 to June 2013. Data were analyzed by using the software Statistical Package for Social Science (SPSS, version 22). Results: Benzodiazepine was the highest (99.3%) prescribed psycholeptic class while Bromazepam (87.49%) the highest advised molecule. Psycholeptics were advised for 15 (38.77%), 10 (19.91%), 30 (15.72%) and 7 (13.39%) days. The patient group without psycholeptic medication (M=6.64 day) spent significantly (p<0.05) a longer duration in the hospital compared to the psycholeptic medication (Mean=5.06 day) group. Age is significantly (p<0.05) associated with the duration of staying in hospital and polymorbidity. Also, polymorbidity (p<0.05) is significantly associated with the polypharmacy. No significant (p<0.05) correlation has been found between age and polypharmacy. Duration of psycholeptics intake was not significantly (p<0.05) related to either age, or polymorbidity,or length hospital stay. Conclusion: This study revealed that bromazepam is the utmost prescribed drug of choice at NICVD, Bangladesh. Frequent prescription of bromazepam indicates that this kind of patients' needs enough sleep to reduce their mental stress.
A study on prescribing patterns of atypical antipsychotic in psychiatric disorders
International Journal of Pharma Research and Health Sciences, 2014
Objective: Psychiatric disorders are one of the important causes of global morbidity and often are chronic disorders requiring treatment with psychopharmacological agents for prolonged periods, may be extending up to a lifetime. The present study was planned to assess the prescribing patterns for atypical antipsychotic in patients suffering from psychiatric disorders. Methods:A six month, Prospective observational study was carried out in an out-patient department. The patients aged 18 -55 years who have been diagnosed with psychiatric illnesses as per ICD-10 classifications and receiving or prescribed with atypical antipsychotic drugs were selected. Results:During the six-month study period, total 100 prescriptions were analyzed. The age group of 25-38 years included 72% of the patients, higher in men (69%). 80% of the patients during the study period were schizophrenia, schizo affective disorders followed by non organic and unspecified disorders. Serotonin dopamine antagonist (37%) followed by multi acting receptor targeted (21%) were the most common drug classes found to be involved in the study. Respiridone (37%), olanzapine (11%) and quetiapine (10%) were the most commonly prescribed drugs in the study population. Among two drug combination therapy involved in the study, the most common was clozapine and respiridone (7%) followed by clozapine and aripriprazole (1%). Conclusions:The study shows that serotonin dopamine antagonist was the most commonly prescribed drug class, respiridone being the commonest. Antipsychotic drug combinations among patients with psychiatric disorders were considerable especially in non responders with a single antipsychotic drug therapy.