Effect of Hypothyroidism on Lipid Profile in Asymptomatic Newly Diagnosed Patients (original) (raw)
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A study of correlation of serum lipid profile in patients with hypothyroidism
International Journal of Medical Science and Public Health, 2015
It results from reduced secretion of either total thyroxine (T4) or triiodothyronine (T3). It leads to hypersecretion of pituitary thyroid-stimulating hormone (TSH) and so greater increase in serum TSH levels. Subclinical hypothyroidism can be defined as a high serum TSH concentration and normal serum total or free T4 and T3 concentrations associated with a few or no symptoms and signs of hypothyroidism. [1] It is referred to as a state of mild thyroid failure. [2] Subclinical hypothyroidism is more common in the elderly and is found twice in women as in men. [3] It is a more common disorder than overt hypothyroidism [4] and hence early diagnosis and treatment may prevent the onset of overt hypothyroidism along with its associated effects. Background: Hypothyroidism is a common problem that reduces the functional ability of life. Hypothyroidism is associated with altered lipid levels, which increases the cardiovascular risk. Objective: The objectives of this study were to study whether there is any correlation between serum lipid levels and hypothyroidism (subclinical and overt) in a rural population of Gujarat and to study whether there is any difference in lipid levels among menopausal and postmenopausal women. Materials and Method: A cross-sectional study was conducted at Clinical Biochemistry department, P.S. Medical College, Karamsad, which consisted 100 hypothyroid patients (subclinical and overt) and 100 similar age-and sex-matched controls. Serum total thyroxine, triiodothyronine, thyroid-stimulating hormone, free thyroxine, serum cholesterol, triglyceride, high-density lipoprotein (HDL) and low-density lipoprotein levels were examined in subclinical and euthyroid patients. Results: In patient with subclinical hypothyroidism, we found elevated serum total cholesterol (217.95) and triglyceride (148.35) levels as compared to controls (P = 0.001) but statistically insignificant HDL level (51.45; P = 0.973). In patient with overt hypothyroidism, elevated serum total cholesterol (271.92) and triglyceride (166.31) were found as compared to control (P = 0.001), but HDL level (46.57; P = 0.134) was found to be decreased. Conclusion: There is association between subclinical and overt hypothyroidism with dyslipidemia. This might be a potential risk factor for coronary artery disease.
Academia Journal of Medicine, 2020
Background : Subclinical hypothyroidism could damage vascular function by suggesting enhance in SVR and arterial rigidity and by changing endothelial purpose and so increasing the danger of atherosclerosis and coronary artery disease. The objective of this study is to analyze the relation amid SCH and serum lipid parameters in this subgroup. Subjects and Methods: Current research was performed for the duration of one year at the Department of Medicine, tertiary care institute of India, in patients diagnosed with Sub Clinical Hypothyroidism. Eighty patients were incorporated in the present study and 80 age- and sex-matched and regularly menstruating healthy controls, which were evaluated for the Thyroid Function test, were randomly recruited from staff and volunteers. T3, T4, and TSH were anticipated by utilizing quantitative hard stage ELISA, whereas TC was estimated with photometric determination according to the CHOD PAP method; TG and HDL were estimated by using the enzymatic col...
A study to assess the relation between severity of hypothyroidism and Lipid parameters
Innovative Publication, 2016
Background: Hypothyroidism is associated with dyslipidemia. The present study was conducted to assess the relation between hypothyroidism and lipid parameters and lipid ratios. It is also done to assess the severity of hypothyroidism on lipid parameters. Methods: Study comprises of 120 participants were divided into four groups depending on TSH levels, each group comprising of 30 participants. Group-1 euthyroid as controls, group-2 hypothyroid patients with TSH levels between 6-20 IU/mL, group-3 TSH levels between 21-50 IU/mL and group-4 consists of hypothyroid patients with TSH levels of > 50 IU/mL. Fasting venous blood was collected from all the participants and analysed for estimation of thyroid profile and lipid profile. Lipid ratios were calculated. Results: There was significant (p < 0.05) increase in total cholesterol, triglycerides, LDL-C and HDL-C in all the groups compared to group-1 i.e controls. There was significant increase (p<0.05) in lipid ratios. There is positive correlation between TSH and lipid parameters. Conclusion: Our study shows hypothyroid patients show dyslipidemia and the effect of hypothyroidism on lipid parameters is more marked in patients with higher serum TSH levels. By calculating the lipid ratios from lipid parameters are better indicators of dyslipidemia and cardiovascular risk in hypothyroid patients.
Effect of Hypothyroidism on lipid profile
2017
Objective: To study the effects of subclinical and overt hypothyroidism on serum levels of low density lipoprotein(LDL), total cholesterol(TC), high density lipoprotein (HDL) and triglycerides(TG). And also to compare the results with normal healthy individuals and with previously published reference data. Lipid profile was estimated in 119 cases of subclinical hypothyroidism and 46 cases of overt hypothyroidism patients attending OPD of a major tertiary health care centre in Punjab. Method: The study was done in the department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar. The serum TSH, FT3, FT4 was done by enhanced chemiluminescence technique using vitros Eci-ortho Clinical Diagnostics and lipid profile on semi autoanalyser. The cases were divided into two groups after studying the thyroid profile i.e. subclinical hypothyroidism characterized by elevated serum TSH with normal FT4 and overt hypothyroidism characterized elevated TSH with low...
Comparison of Lipid Profile in Patients With and Without Subclinical Hypothyroidism
Cureus, 2021
Introduction: Thyroid hormone affects lipid metabolism. Various studies have shown a contradictory relationship between lipid profile (LP) and subclinical hypothyroidism (SCH). Currently, there is a scarcity of regional data on the relationship between LP and SCH. Methods: This longitudinal study was conducted in the internal medicine and cardiology units of a tertiary care hospital in Pakistan from September 2019 to March 2021. A total of 900 participants, of either gender and between the ages of 40 to 70 years, were enrolled in the study. Blood samples were sent to the laboratory to determine lipid and thyroid parameters. Participants were divided into two groups based on the presence of SCH. Results: In our study, 179 (19.8%) participants had SCH. Total cholesterol (TC) and low-density lipoprotein (LDL) was significantly higher in participants with SCH compared to participants without SCH (228.41 ± 35.21 mg/dL vs. 171.21 ± 30.21 mg/dL; p-value: <0.00001) and (131.65 ± 28.22 mg/dL vs. 89.26 ± 18.52 mg/dL; p-value: <0.0001), respectively. Conclusion: In conclusion, this study found an increased incidence of dyslipidemias in patients with SCH. It is associated with elevated TC and LDL levels, which are risk factors for cardiovascular disease and mortality.
Journal of Pharmaceutical Research International
Aims: Aim of this investigation was to access the association of dyslipidemia with subclinical hypothyroidism. Methodology: In this cross-sectional investigation, 1948 participants were recruited. Two groups were made; participants up to 18 years were in group A and Subjects over 18 years were incorporated in group 2. They were subdivided into control, subclinical hypothyroid 1, and subclinical hypothyroid 2. SPSS 21 was used for data analysis. Results: Data of 1619 individuals were analyzed. The mean age of Group A participants was 12.79 ± 2.779, and the mean age of Group B participants was 42.58 ± 18.012. The prevalence of subclinical hypothyroid was found at 13.5 %. Significant differences have been observed while comparing Group A and Group B (P <0.001). Free tetraiodothyronine and Free triiodothyronine also showed a significant difference in both groups. (P<0.05). No significant difference between mean Thyroid-stimulating hormone levels was observed (P>0.05). No signi...
Study of Lipid Profile in Patients of Hypothyroidism
IOSR Journals , 2019
Assocation between hypothyroidism and lipid profile has been focussed in this study. This is an observational study. Lipid profile in 200 patients of hypothyroidism has been studied in this study. Chemiluminescence (CLIA) Method was used to estimate levels ofT3,T4,TSH quantitatively serum was estimated on the fully automated biochemistry analyser using the analyser specific Roche kit for total serum cholesterol, HDL cholesterol, and triglycerides. Friedwalds formula was used to calculate LDL cholesterol.Out of 200 patients 135 were of subclinical hypothyroidism and 65 belong to overt hypothyroidism. Females had higher prevalence consisting of 85% of cases.
Study of serum lipid profile in subclinical hypothyroidism
Objective: It has been known that overt hypothyroidism is associated with hyperlipidemia, replacement therapy with Levothyroxine significantly reverses lipid metabolism abnormalities. But no clear consensus has been established regarding the treatment of Subclinical Hypothyroidism subjects. This is due to the fact that there are no data from large trials on whether and to what degree Subclinical Hypothyroidism affects lipid profile. This study is aimed to provide a look at the status of Lipid Profile in the case of Subclinical Hypothyroidism. Materials and Methods: Total 100 subjects were recruited and divided into 2 groups. 50 Patients with Subclinical Hypothyroidism were considered as the cases and 50 healthy people as the controls. Serum TSH was analysed by sandwich electrochemiluminescence immunoassay method. Serum cholesterol, triglyceride and HDL were estimated by enzymatic colorimetric method, LDL was calculated by using friedewald formula. Results: Serum cholesterol, LDL were higher (P<0.0001) and HDL (P<0.0001) was lower in Subclinical Hypothyroid patients (mean±SD= 199.9±27.8 mg/dl, 130.0±26.3mg/dl, 44.2±9.1 mg/dl respectively) compared to healthy controls (mean±SD= 170.1±16.8 mg/dl, 97.3±14.7 mg/dl, 54.2±10.0 mg/dl respectively). A significant correlation was found between the levels of TSH and Serum Cholesterol (r=0.5101, P<0.0001), LDL (r=0.5637, P<0.0001) and a significant negative correlation was found between the levels of TSH and HDL (r=-0.4525, P<0.0001). Conclusion: Subclinical hypothyroidism is associated with elevated levels of Serum Total Cholesterol and LDL which is atherogenic in nature, and low level of HDL. This may further increase the risk of development of atherosclerosis.
JNMA; journal of the Nepal Medical Association, 2021
INTRODUCTION Thyroid hormones have a major influence on synthesis, mobilization and metabolism of lipids. Hypothyroidism accounts for a notable cause of secondary dyslipidemia. This can increase the risk for cardiovascular morbidity and mortality. This study was performed to find out the prevalence of lipid profile abnormalities in newly diagnosed primary hypothyroid states. METHODS This descriptive cross-sectional study was conducted among 71 patients in the context of newly diagnosed primary hypothyroidism patients visiting outpatient department of internal medicine from 9th December 2018 to 30th June 2020 after taking ethical clearance from Institutional Review Committee. Case screening for lipid profile changes was performed at the time of diagnosis of primary hypothyroidism. A convenience sampling method was used. Data entry and descriptive analysis were done in Statistical Package for the Social Sciences version 16.0. Point estimate at 95% Confidence Interval was calculated al...
Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism
International Journal of Research in Medical Sciences, 2014
Background: Hypothyroidism has become a highly prevalent condition worldwide as well as in India. Females are affected more than men and dyslipidemia has been associated with hypothyroidism. This study was conducted to study the prevalence and pattern of dyslipidemia in hypothyroid patients and to justify the screening of lipid profile in hypothyroid patients. Methods: This was a case control study which included 50 newly diagnosed and untreated hypothyroid patients and 50 healthy individuals in the age group of 20-40years. Free Triiodothyronine (FT3), free thyroxine (FT4), Thyroid Stimulating Hormone (TSH) were estimated by chemiluminiscence immunoassay. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), blood glucose were done in all the subjects by enzymatic colorimetric method. Low density lipoprotein cholesterol (LDL-C) was calculated using Friedwalds formula. Very Low density lipoprotein cholesterol (VLDL-C) was calculated from the triglyceride value. Results: Lipid profile alterations were seen in hypothyroid patients. The mean (standard deviation)values of Total cholesterol, high density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Very Low density lipoprotein cholesterol (VLDL-C), triglycerides (TG), Fasting blood glucose were 183.7 (32.9), 38.12 (7.59), 104.4 (29.42), 31.66 (13.09), 158.44 (65.61), 95.9(9.9) mg/dl respectively. The statistical analysis showed that the difference in the above values between cases and controls was significant and all the mean values except HDL-C were increased in cases. Conclusions: Hypothyroid patients demonstrate significant increase in serum lipids as compared to healthy individuals. More females are diagnosed with hypothyroidism and dyslipidemia is associated with primary hypothyroidism.