Influence of the Isotype of the Light Chain on the Properties of IgG1 (original) (raw)

This study investigates the influence of light chain isotype on the structural and functional properties of IgG1 antibodies. The authors demonstrate that while the isotype of the light chain has a slight impact on the assembly kinetics and functional stability of IgG antibodies, the overall functional characteristics primarily rely on the heavy chain isotype. Key findings include variations in intracellular assembly rates and in vivo half-lives for different antibodies, particularly highlighting the differences noted for IgG2.