Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence (original) (raw)

Pancreatic cancer (PC) is characterized by a high rate of recurrence post-surgery, and this study investigates molecular determinants associated with different recurrence patterns. Analyses of genomic and transcriptomic data from a cohort of patients revealed that liver recurrence is correlated with the squamous (basal-like) subtype of tumors, while lung recurrence is associated with the classical subtype. Key molecular pathways involved include cell cycle control and glycolysis for liver recurrence, whereas pluripotent stem cell regulation is linked to lung recurrence. These findings underscore the heterogeneity of PC recurrence and its genetic underpinnings.